1.
Angew Chem Int Ed Engl
; 54(19): 5628-31, 2015 May 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25784151
RESUMO
The activation of CD8(+) T-cells requires the uptake of exogenous polypeptide antigens and proteolytic processing of these antigens to octamer or nonamer peptides, which are loaded on MHC-I complexes and presented to the T-cell. By using an azide as a bioorthogonal protecting group rather than as a ligation handle, masked antigens were generated-antigens that are not recognized by their cognate T-cell unless they are deprotected on the cell using a Staudinger reduction.