Population frequencies of the Triallelic 5HTTLPR in six Ethnicially diverse samples from North America, Southeast Asia, and Africa.

Genetic differences between populations are potentially an important contributor to health disparities around the globe. As differences in gene frequencies influence study design, it is important to have a thorough understanding of the natural variation of the genetic variant(s) of interest. Along these lines, we characterized the variation of the 5HTTLPR and rs25531 polymorphisms in six samples from North America, Southeast Asia, and Africa (Cameroon) that differ in their racial and ethnic composition. Allele and genotype frequencies were determined for 24,066 participants. Results indicated higher frequencies of the rs25531 G-allele among Black and African populations as compared with White, Hispanic and Asian populations. Further, we observed a greater number of 'extra-long' ('XL') 5HTTLPR alleles than have previously been reported. Extra-long alleles occurred almost entirely among Asian, Black and Non-White Hispanic populations as compared with White and Native American populations where they were completely absent. Lastly, when considered jointly, we observed between sample differences in the genotype frequencies within racial and ethnic populations. Taken together, these data underscore the importance of characterizing the L-G allele to avoid misclassification of participants by genotype and for further studies of the impact XL alleles may have on the transcriptional efficiency of SLC6A4.

The Phenomenology of Non-Aggressive Antisocial Behavior During Childhood.

Although the phenomenology of overt or aggressive antisocial behavior during childhood is well-documented, far less is known about covert or non-aggressive, rule-breaking (RB) antisocial behavior. Gaps in knowledge include issues as basic as RB's typical symptom presentation during childhood and which symptoms differ across sex. The current study sought to fill these gaps in the literature by establishing the prevalence and psychometric properties of specific RB behaviors in a sample of 1022 twin boys and 1010 twin girls between the ages of 6 and 10 years. Legal RB behaviors (e.g., breaking rules, swears, lying or cheating) were present to varying degrees in most children, regardless of whether or not they passed the clinical threshold for RB. They were also more common in boys than in girls regardless of their clinical status. In sharp contrast, illegal RB behaviors (e.g., stealing, vandalism, setting fires) were rarely observed in typically-developing children, but were seen at moderate levels in boys and girls with clinically-significant levels of RB. Moreover, sex differences in illegal RB behaviors were observed only for those youth with clinically meaningful levels of RB. Such findings collectively imply that while legal RB behaviors can be found (albeit at different frequencies) in children with and without clinically meaningful levels of RB, illegal RB behaviors may function as relatively 'unambiguous' indicator of clinically-significant levels of RB.

A comparison of three self-report measures of the broader autism phenotype in a non-clinical sample.

Three self-report measures of the broader autism phenotype (BAP) were evaluated in terms of their internal consistency, distribution of scores, factor structure, and criterion-related validity in a non-clinical sample. All measures showed a continuous distribution. The SRS-A and BAPQ showed expected sex differences and were superior to the AQ in terms of internal consistency. The proposed factor structure of the BAPQ replicated better than the proposed structures of the other measures. All measures showed evidence of criterion validity via correlations with related constructs and each measure incremented the others in predicting related constructs. However, the SRS-A and BAPQ were generally stronger in this domain. Recommendations for the use of these instruments for measuring the BAP in non-clinical populations are discussed.