Detalhe da pesquisa
1.
DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.
Nucleic Acids Res
; 52(3): 1136-1155, 2024 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38038252
2.
TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.
Cell
; 142(2): 230-42, 2010 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655466
3.
Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res
; 51(21): 11732-11747, 2023 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37870477
4.
Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells.
Nucleic Acids Res
; 49(18): 10275-10288, 2021 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34551430
5.
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.
Nucleic Acids Res
; 49(17): 9906-9925, 2021 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500463
6.
ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks.
Nucleic Acids Res
; 48(17): 9710-9723, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32890395
7.
DNA Junction Ligands Trigger DNA Damage and Are Synthetic Lethal with DNA Repair Inhibitors in Cancer Cells.
J Am Chem Soc
; 142(1): 424-435, 2020 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31833764
8.
2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology.
Chembiochem
; 20(7): 968-973, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30803119
9.
Alkyne-Tagged Analogue of Jaspineâ B: New Tool for Identifying Jaspineâ B Mode of Action.
Chembiochem
; 19(23): 2438-2442, 2018 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30303294
10.
A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function.
EMBO Rep
; 17(4): 508-18, 2016 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26964895
11.
Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein.
Nucleic Acids Res
; 43(21): 10264-76, 2015 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-26350212
12.
DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal.
Nucleic Acids Res
; 42(14): 9047-62, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25030905
13.
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.
Nat Chem Biol
; 8(3): 301-10, 2012 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22306580
14.
Biased and unbiased strategies to identify biologically active small molecules.
Bioorg Med Chem
; 22(16): 4474-89, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24811300
15.
Identification of the main barriers to Ku accumulation in chromatin.
bioRxiv
; 2024 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38260538
16.
Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids.
J Med Chem
; 66(20): 13918-13945, 2023 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37816126
17.
Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA.
Eur J Med Chem
; 259: 115646, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37482022
18.
PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv
; 9(22): eadg2834, 2023 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37256950
19.
SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.
Elife
; 112022 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35535493
20.
DNA folds threaten genetic stability and can be leveraged for chemotherapy.
RSC Chem Biol
; 2(1): 47-76, 2021 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35340894