Detalhe da pesquisa
1.
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease.
J Autoimmun
; 144: 103181, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38522129
2.
New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function.
Ann Rheum Dis
; 82(11): 1415-1428, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37580108
3.
Dapagliflozin protects the kidney in a non-diabetic model of cardiorenal syndrome.
Pharmacol Res
; 188: 106659, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36646190
4.
Interleukin-17 (IL-17) triggers systemic inflammation, peripheral vascular dysfunction, and related prothrombotic state in a mouse model of Alzheimer's disease.
Pharmacol Res
; 187: 106595, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36470548
5.
Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2'-Deoxyguanosine and 2'-Substituted RNA Analogues.
Int J Mol Sci
; 24(21)2023 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37958511
6.
Structural and Biological Features of G-Quadruplex Aptamers as Promising Inhibitors of the STAT3 Signaling Pathway.
Int J Mol Sci
; 24(11)2023 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298475
7.
Erucin, an H2S-Releasing Isothiocyanate, Exerts Anticancer Effects in Human Triple-Negative Breast Cancer Cells Triggering Autophagy-Dependent Apoptotic Cell Death.
Int J Mol Sci
; 24(7)2023 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37047736
8.
Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio.
Pharmacol Res
; 182: 106283, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35662629
9.
Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.
Pharmacol Res
; 177: 106108, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35121122
10.
Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives.
Nucleic Acids Res
; 48(22): 12556-12565, 2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33270863
11.
Properties and Potential Antiproliferative Activity of Thrombin-Binding Aptamer (TBA) Derivatives with One or Two Additional G-Tetrads.
Int J Mol Sci
; 23(23)2022 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36499249
12.
Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis.
FASEB J
; 33(2): 2809-2822, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30303744
13.
Searching for novel hydrogen sulfide donors: The vascular effects of two thiourea derivatives.
Pharmacol Res
; 159: 105039, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32565313
14.
The "Janus face" of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications.
Bioorg Chem
; 76: 202-209, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29190476
15.
Decoding the vasoregulatory activities of bile acid-activated receptors in systemic and portal circulation: role of gaseous mediators.
Am J Physiol Heart Circ Physiol
; 312(1): H21-H32, 2017 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27765751
16.
Backbone modified TBA analogues endowed with antiproliferative activity.
Biochim Biophys Acta Gen Subj
; 1861(5 Pt B): 1213-1221, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27663232
17.
Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity.
Nucleic Acids Res
; 43(22): 10602-11, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26582916
18.
Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.
Nucleic Acids Res
; 43(16): 7702-16, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26250112
19.
Cystathionine ß-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia.
Clin Sci (Lond)
; 130(1): 35-44, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26460077
20.
Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide.
Pharmacol Res
; 111: 556-562, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27378567