Detalhe da pesquisa
1.
Structural insights into the catalysis and regulation of E3 ubiquitin ligases.
Nat Rev Mol Cell Biol
; 17(10): 626-42, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27485899
2.
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer.
EMBO J
; 42(18): e113987, 2023 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37577760
3.
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol Cell
; 68(2): 456-470.e10, 2017 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29053960
4.
Activation of a primed RING E3-E2-ubiquitin complex by non-covalent ubiquitin.
Mol Cell
; 58(2): 297-310, 2015 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25801170
5.
Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
BMC Biol
; 14: 76, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27609087
6.
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.
Oncogene
; 40(12): 2149-2164, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33627783
7.
DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Sci Adv
; 6(34)2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32937373
8.
Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.
Sci Adv
; 6(38)2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32948590
9.
Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation.
Structure
; 27(9): 1452-1459.e4, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31303481
10.
Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis.
J Mol Biol
; 369(2): 305-12, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17434525
11.
Single-Turnover RING/U-Box E3-Mediated Lysine Discharge Assays.
Methods Mol Biol
; 1844: 19-31, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30242700
12.
Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development.
J Bacteriol
; 189(24): 8922-7, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17921290
13.
Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.
J Mol Biol
; 356(4): 1005-13, 2006 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-16405912
14.
The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery.
BMC Struct Biol
; 7: 68, 2007 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17956607
15.
Structure of Staphylococcus aureus1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 63(Pt 11): 908-13, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18007038
16.
The nucleotide-binding site of Aquifex aeolicus LpxC.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 62(Pt 11): 1082-6, 2006 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17077484
17.
Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3.
Nat Struct Mol Biol
; 20(8): 982-986, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23851457
18.
BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.
Nat Struct Mol Biol
; 19(9): 876-83, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22902369
19.
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Nat Struct Mol Biol
; 19(2): 184-92, 2012 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22266821
20.
A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy.
J Med Chem
; 52(8): 2531-42, 2009 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19320487