1.
Bioorg Med Chem Lett
; 17(23): 6467-71, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17937984
RESUMO
A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility.