Detalhe da pesquisa
1.
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 49(16): 9026-9041, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417625
2.
Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice.
Toxicol Pathol
; 47(1): 82-92, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30585133
3.
Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
Nucleic Acids Res
; 44(5): 2093-109, 2016 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26553810
4.
Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers.
Mol Ther
; 24(10): 1771-1782, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27357629
5.
Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events.
Clin Transl Sci
; 16(4): 575-580, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36631935
6.
Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.
J Pharmacol Exp Ther
; 342(1): 150-62, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22505629
7.
Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells.
Nucleic Acid Ther
; 32(6): 473-485, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36355073
8.
Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells.
Nucleic Acid Ther
; 32(6): 457-472, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35976085
9.
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia.
Nucleic Acid Ther
; 30(2): 94-103, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32043907
10.
Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2'-O-Methoxyethyl Antisense Oligonucleotide.
Nucleic Acid Ther
; 29(5): 266-277, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31368839
11.
Investigation into the Mechanism(s) That Leads to Platelet Decreases in Cynomolgus Monkeys During Administration of ISIS 104838, a 2'-MOE-Modified Antisense Oligonucleotide.
Toxicol Sci
; 164(2): 613-626, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29846725
12.
Assessment of the Effects of 2'-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates.
Nucleic Acid Ther
; 27(4): 197-208, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28541820
13.
Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.
J Med Chem
; 59(6): 2718-33, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26914862
14.
Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.
Nucleic Acid Ther
; 23(3): 213-27, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23692080
15.
Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development.
Proc Natl Acad Sci U S A
; 101(49): 17186-91, 2004 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15569932