Detalhe da pesquisa
1.
AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues.
J Transl Med
; 12: 307, 2014 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25367255
2.
Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
J Med Chem
; 2024 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38889244
3.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg Med Chem Lett
; 22(15): 4967-74, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22765895
4.
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Bioorg Med Chem Lett
; 21(7): 2064-70, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21376583
5.
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer.
ACS Med Chem Lett
; 12(8): 1245-1252, 2021 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34422225
6.
Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer.
Mol Cancer Ther
; 20(5): 763-774, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33649102
7.
Discovery and evaluation of dual CDK1 and CDK2 inhibitors.
Cancer Res
; 66(8): 4299-308, 2006 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16618755
8.
Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines.
J Med Chem
; 58(13): 5189-207, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25970324
9.
Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity.
Cancer Cell
; 26(2): 177-89, 2014 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043603
10.
AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models.
Mol Cancer Ther
; 12(11): 2356-66, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23990115
11.
Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors.
J Exp Clin Cancer Res
; 29: 96, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20633291
12.
Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.
J Med Chem
; 53(17): 6368-77, 2010 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20684549
13.
Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
Cancer Res
; 70(23): 9846-54, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20935223