Detalhe da pesquisa
1.
Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia.
FASEB J
; 36(10): e22514, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36106439
2.
Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia.
FASEB J
; 36(1): e22094, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34888943
3.
A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer.
Exp Cell Res
; 388(2): 111860, 2020 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31972222
4.
Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen.
Exp Cell Res
; 381(2): 256-264, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31112736
5.
Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation.
J Lipid Res
; 60(6): 1078-1086, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962310
6.
Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells.
J Lipid Res
; 60(9): 1590-1602, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31363040
7.
Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia.
J Lipid Res
; 57(7): 1231-42, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27140664
8.
Tamoxifen regulation of sphingolipid metabolism--Therapeutic implications.
Biochim Biophys Acta
; 1851(9): 1134-45, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25964209
9.
Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics.
Biochim Biophys Acta
; 1851(7): 919-28, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25769964
10.
Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells.
Biochim Biophys Acta
; 1831(12): 1657-64, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23939396
11.
Mitochondria inside acute myeloid leukemia cells hydrolyze ATP to resist chemotherapy.
bioRxiv
; 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38659944
12.
Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia.
bioRxiv
; 2023 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37961314
13.
Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types.
Sci Rep
; 13(1): 16742, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37798427
14.
Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia.
Cancers (Basel)
; 15(24)2023 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38136410
15.
Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia.
Cancers (Basel)
; 15(6)2023 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36980769
16.
C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.
Breast Cancer Res Treat
; 133(2): 447-58, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21935601
17.
P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells.
Exp Cell Res
; 317(12): 1736-45, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21396934
18.
Intrinsic adaptations in OXPHOS power output and reduced tumorigenicity characterize doxorubicin resistant ovarian cancer cells.
Biochim Biophys Acta Bioenerg
; 1863(8): 148915, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36058252
19.
Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia.
Blood Rev
; 55: 100950, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35487785
20.
Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide.
Prostate
; 71(10): 1064-73, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21557271