Detalhe da pesquisa
1.
Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
Cell
; 171(5): 1165-1175.e13, 2017 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29149605
2.
Structure-based design of bitopic ligands for the µ-opioid receptor.
Nature
; 613(7945): 767-774, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36450356
3.
Small molecule 1a reduces FMRpolyG-mediated toxicity in in vitro and in vivo models for FMR1 premutation.
Hum Mol Genet
; 30(17): 1632-1648, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34077515
4.
Basolateral amygdala corticotropin releasing factor receptor 2 interacts with nonmuscle myosin II to destabilize memory in males.
Neurobiol Learn Mem
; 206: 107865, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37995804
5.
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling.
Nat Chem Biol
; 17(3): 307-316, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33510451
6.
DNA-Encoded Library Screening To Inform Design of a Ribonuclease Targeting Chimera (RiboTAC).
J Am Chem Soc
; 144(46): 21096-21102, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36342850
7.
Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2.
J Am Chem Soc
; 144(46): 21035-21045, 2022 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36356199
8.
Development of a putative Zn2+-chelating but highly selective MMP-13 inhibitor.
Bioorg Med Chem Lett
; 76: 129014, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36202189
9.
Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model.
Proc Natl Acad Sci U S A
; 116(16): 7799-7804, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926669
10.
Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.
J Am Chem Soc
; 143(33): 13044-13055, 2021 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387474
11.
Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.
PLoS Biol
; 16(6): e2004663, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889904
12.
M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.
Proc Natl Acad Sci U S A
; 114(43): E9135-E9144, 2017 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29073110
13.
Precise small-molecule recognition of a toxic CUG RNA repeat expansion.
Nat Chem Biol
; 13(2): 188-193, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27941760
14.
Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models.
Mol Pharm
; 16(7): 3065-3071, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31244223
15.
Design of a small molecule against an oncogenic noncoding RNA.
Proc Natl Acad Sci U S A
; 113(21): 5898-903, 2016 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27170187
16.
Identification of an aminothiazole series of RORß modulators.
Bioorg Med Chem Lett
; 28(7): 1178-1181, 2018 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534930
17.
Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists.
Bioorg Med Chem Lett
; 28(8): 1313-1319, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29548571
18.
Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study.
Bioorg Med Chem
; 26(18): 4984-4995, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249495
19.
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.
Nature
; 485(7396): 62-8, 2012 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22460951
20.
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response.
Nature
; 483(7391): 613-7, 2012 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22425996