Detalhe da pesquisa
1.
Ursolic acid derivatives as potential antidiabetic agents: In vitro, in vivo, and in silico studies.
Drug Dev Res
; 79(2): 70-80, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29380400
2.
Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme.
Biochim Biophys Acta
; 1864(10): 1339-55, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27421795
3.
In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.
Bioorg Med Chem Lett
; 26(8): 2018-22, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961283
4.
The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment.
Biochim Biophys Acta
; 1830(4): 3102-11, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23352912
5.
The effects of CA IX catalysis products within tumor microenvironment.
Cell Commun Signal
; 11: 81, 2013 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24168032
6.
PrPc activation induces neurite outgrowth and differentiation in PC12 cells: role for caveolin-1 in the signal transduction pathway.
J Neurochem
; 110(1): 194-207, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19457127
7.
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.
Bioorg Med Chem
; 17(7): 2658-72, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19297174
8.
5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.
Bioorg Med Chem
; 17(5): 1928-37, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217304
9.
Synthesis, in vitro and computational studies of protein tyrosine phosphatase 1B inhibition of a small library of 2-arylsulfonylaminobenzothiazoles with antihyperglycemic activity.
Bioorg Med Chem
; 17(9): 3332-41, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19362487
10.
Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1.
Biochim Biophys Acta
; 1770(5): 753-62, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17296269
11.
Kinetic mechanism of the Zn-dependent aryl-phosphatase activity of myo-inositol-1-phosphatase.
Biophys Chem
; 125(2-3): 435-43, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17112654
12.
Effect of natural compounds on insulin signaling.
Curr Med Chem
; 22(1): 80-111, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25139055
13.
Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.
Eur J Med Chem
; 71: 112-27, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24287560
14.
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.
Eur J Med Chem
; 87: 316-27, 2014 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25264584
15.
New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.
Eur J Med Chem
; 50: 332-43, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22381357
16.
Synthesis, in vitro and in silico screening of ethyl 2-(6-substituted benzo[d]thiazol-2-ylamino)-2-oxoacetates as protein-tyrosine phosphatase 1B inhibitors.
Eur J Med Chem
; 53: 346-55, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22583779
17.
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.
Eur J Med Chem
; 46(6): 2243-51, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21453996
18.
Protein N-homocysteinylation induces the formation of toxic amyloid-like protofibrils.
J Mol Biol
; 400(4): 889-907, 2010 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20510245
19.
Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase.
ChemMedChem
; 4(6): 957-62, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19288492
20.
Proliferation versus migration in platelet-derived growth factor signaling: the key role of endocytosis.
J Biol Chem
; 283(29): 19948-56, 2008 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18499659