Detalhe da pesquisa
1.
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.
Cell
; 160(4): 745-758, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25662011
2.
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
Cell
; 156(1-2): 304-16, 2014 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24439384
3.
CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.
Immunity
; 45(3): 583-596, 2016 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27566941
4.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.
Nature
; 517(7534): 391-5, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25409143
5.
In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.
Biochem J
; 475(6): 1063-1074, 2018 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29483297
6.
Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.
Proc Natl Acad Sci U S A
; 113(8): 2212-7, 2016 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26858428
7.
Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.
Diabetologia
; 61(6): 1435-1446, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29497783
8.
A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice.
FASEB J
; 31(7): 2916-2924, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28330852
9.
Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.
Proc Natl Acad Sci U S A
; 112(4): 1143-8, 2015 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25564660
10.
Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.
Proc Natl Acad Sci U S A
; 111(46): 16508-13, 2014 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25368185
11.
Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.
Am J Physiol Endocrinol Metab
; 311(1): E105-16, 2016 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27166280
12.
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo.
Proc Natl Acad Sci U S A
; 110(31): 12780-5, 2013 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23840067
13.
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
Proc Natl Acad Sci U S A
; 110(5): 1869-74, 2013 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23302688
14.
ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.
J Lipid Res
; 56(3): 526-536, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25548259
15.
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.
Proc Natl Acad Sci U S A
; 109(37): 14966-71, 2012 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22912404
16.
Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.
Diabetologia
; 57(6): 1232-41, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24718953
17.
Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance.
Proc Natl Acad Sci U S A
; 112(8): E825, 2015 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25617370
18.
Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.
Nat Med
; 25(3): 526-528, 2019 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-30733621
19.
Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance.
Diabetes
; 67(4): 624-635, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29317435
20.
Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.
Diabetes
; 67(2): 208-221, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29203511