RESUMO
Effectively addressing the challenges posed by relapsed and refractory diffuse large B-cell lymphoma, particularly when employing autologous hematopoietic stem cell transplantation and CAR-T therapy, requires a comprehensive approach to treatment and nursing. This case report emphasizes a nursing strategy focused on managing neurotoxicity post-CAR-T therapy. Nursing interventions include the identification of neurotoxicity symptoms, neuropsychiatric management, careful support during lumbar puncture and intrathecal administration, psychological assistance, and adaptive nutritional guidance. The diligent application of treatment and nursing care resulted in a remarkable recovery for the patient, as evidenced by the alleviation of central facial paralysis, improvement in swallowing function (from Grade 4 to Grade 2), and enhanced vocalization. Consistent and specialized nursing care is paramount for effectively managing complications, especially neurotoxicity, in patients undergoing CAR-T therapy. A thorough monitoring of symptoms and personalized care contribute to optimizing treatment outcomes and ensuring patient safety.
RESUMO
Inclusive green growth (IGG) offers an effective alternative to pursue sustainable development. The core of the IGG system lies in the coordination of inclusive, green, and growth subsystems. However, there is little quantitative assessment on IGG based on subsystem collaboration. This study proposes a holistic scheme of inclusive-green-growth nexus in Anhui province from 2009 to 2018 by using an integrated approach, namely, the entropy weight approach (EWA), coupling coordination degree model (CCDM), grey prediction model (GPM), and obstacle factor diagnostic model (OFDM). The results show that: (1) The proposed integrated approach could be viable to measure the synergistic interactions among internal IGG subsystems; (2) At the provincial level, a relatively high IGG performance but a low coupling coordination degree (CCD) of the IGG nexus are seen. Although the predicted value of CCD will show an upward trend, it will not be able to cross the start stage. The obstacle factors on the coordinated development of IGG can be divided into two stages: (3) At the prefectural level, the cities in which CCD is rising outnumber those it is falling. However, the CCD is also low, and the gap between cities is getting wider. The obstacles that affect the CCD of cities see a dynamic evolution trend from "inclusive obstacle type" to "inclusive and growth obstacle type" then to "green obstacle type" over the decade.