[Association of single nucleotide polymorphisms of TBX5 gene and environmental exposure index with susceptibility to oral cancer].

Objective: To explore the association of TBX5 polymorphisms and environmental exposure index with susceptibility to oral cancer. Methods: A case-control study was conducted to collect 300 oral cancer patients hospitalized in the Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Fujian Medical University from September 2010 to December 2016. A total of 445 non-tumor patients were selected as the control group. Questionnaires were used to collect the information of all subjects and 5 ml peripheral blood was collected to detect single nucleotide polymorphisms (SNPs) of the rs10492336 locus of TBX5 gene. According to the environmental exposure index score, subjects were divided into two groups, low risk group (0-2.31) and high risk group (2.32-11.76). To analyze the association of TBX5 gene rs10492336 SNPs, environmental exposure index and oral cancer and its interactions. Results: The age of all subjects in the case group and control group were (56.19±13.10) years and (54.56±12.48) years old. Compared with CC genotype, the OR (95%CI) values of the co-dominant genetic model AC genotype and the dominant genetic model AC+AA genotype were 0.69 (0.49-0.98) and 0.70 (0.51-0.97), respectively. Compared with the low risk group, the OR (95%CI) risk of oral cancer in the high risk group was 3.72 (2.55-5.43). The results of gene-environment interaction analysis showed that compared with the group with CC genotype and high risk of environmental exposure index, the OR (95%CI) value of oral cancer in the group with AC+AA genotype and low risk of environmental exposure index was 0.18(0.10-0.31). Furthermore there was a multiplicative interaction between rs10492336 SNPs and environmental exposure index (ß=-0.405, P<0.001). Conclusion: This study suggests that the TBX5 gene rs10492336 SNPs and environmental exposure index were associated with oral cancer. And there was a multiplication interaction between rs10492336 SNPs and environmental exposure index.

Application of three-dimensional technology in orthognathic surgery: a narrative review.

With the recent advances in three-dimensional (3D) technology, orthognathic surgery has steadily evolved, gradually performing more sophisticated surgery and expanding its scope of application. The objective of this study is to summarize the current evidence of the application of 3D technology in the field of orthognathic surgery, with the hope of providing helpful information for practitioners who are interested in orthognathic surgery. Peer-reviewed articles published in English were retrieved from literature through an extensive search performed in PubMed/MEDLINE. The application of 3D technology in orthognathic surgery can be summarized from the aspects of preoperative diagnosis, surgical planning, surgical procedure and postoperative evaluation. There is evidence that supports the use of 3D technology, including cone beam computed tomography (CBCT), 3D imaging devices, 3D printing technology, navigation, computer-aided design and computer-aided manufacturing (CAD/CAM), can help improving orthognathic surgery and achieving promising outcomes. Even though there may be an added cost, the application of 3D technology has provided decreased operative time and hospital length of stay, which is positive for both practitioners and patients. With precision and minimal invasiveness, 3D technology is considered to be an effective method in exploring more scientific and reasonable programs and procedures of orthognathic surgery.