Detalhe da pesquisa
1.
The Comparison of Machine Learning and Mechanistic In Vitro-In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance.
Mol Pharm
; 20(11): 5616-5630, 2023 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37812508
2.
High and Low Frequency Domino Liver Transplantation Centers Demonstrate Similar Performance Outcomes.
J Surg Res
; 269: 144-150, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34563840
3.
Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay.
Protein Expr Purif
; 177: 105749, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32911062
4.
In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier.
Drug Metab Dispos
; 47(4): 405-411, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30683809
5.
Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.
J Pharmacol Exp Ther
; 367(2): 322-334, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30135178
6.
Corrigendum to 'Production of active recombinant human aldehyde oxidase (AOX) in the baculovirus expression vector system (BEVS) and deployment in a pre-clinical fraction-of-control AOX compound exposure assay' [Protein Expr. Purif. 177 (2020) 105749].
Protein Expr Purif
; 179: 105769, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33127220
7.
Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery.
AAPS J
; 26(3): 38, 2024 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38548986
8.
Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes.
AAPS J
; 26(3): 36, 2024 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38546903
9.
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
J Med Chem
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38687966
10.
Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Bioorg Med Chem Lett
; 23(24): 6588-92, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24239482
11.
In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes.
AAPS J
; 25(3): 40, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37052732
12.
Inactivation Kinetics of G-Quadruplex/Hemin Complex and Optimization for More Reliable Catalysis.
Chempluschem
; 87(7): e202200090, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35543203
13.
Rapid Nucleic Acid Reaction Circuits for Point-of-care Diagnosis of Diseases.
Curr Top Med Chem
; 22(8): 686-698, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35139798
14.
Synthesis of Deuterated Heterocycles with Me2NCD(OMe)2 and Evaluation of the Products for Metabolism by Aldehyde Oxidase.
ACS Med Chem Lett
; 13(2): 250-256, 2022 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35178182
15.
COVID-19 and neurodegeneration: The mitochondrial connection.
Aging Cell
; 21(11): e13727, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36219531
16.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Science
; 374(6575): 1586-1593, 2021 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726479
17.
A Physiologically Based in Silico Tool to Assess the Risk of Drug-Related Crystalluria.
J Med Chem
; 63(12): 6489-6498, 2020 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32130005
18.
Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes.
Eur J Pharm Sci
; 155: 105541, 2020 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32927071
19.
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
ACS Med Chem Lett
; 9(2): 125-130, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456800
20.
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.
ACS Med Chem Lett
; 6(11): 1128-33, 2015 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26617966