Detalhe da pesquisa
1.
Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.
PLoS Comput Biol
; 19(5): e1011050, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37146076
2.
An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension.
Diabetologia
; 63(4): 733-743, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31858186
3.
An Experimental Test of the Effectiveness of Unsolicited Reporting by a Prescription Drug Monitoring Program in Reducing Inappropriate Acquisition of Opioids.
Pain Med
; 20(5): 944-954, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29868715
4.
Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.
Proc Natl Acad Sci U S A
; 110(52): E5088-97, 2013 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24309376
5.
The ecology of prescription opioid abuse in the USA: geographic variation in patients' use of multiple prescribers ("doctor shopping").
Pharmacoepidemiol Drug Saf
; 23(12): 1258-67, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25111716
6.
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
Proc Natl Acad Sci U S A
; 107(51): 22255-9, 2010 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21139054
7.
PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19.
Commun Biol
; 5(1): 808, 2022 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35962188
8.
Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients.
medRxiv
; 2022 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35441166
9.
Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity.
Mol Ther Nucleic Acids
; 29: 923-940, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36032397
10.
Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4.
J Am Chem Soc
; 133(40): 15878-81, 2011 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21905700
11.
Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.
Bioorg Med Chem Lett
; 21(22): 6856-60, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21962575
12.
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.
Nat Biomed Eng
; 5(8): 815-829, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33941899
13.
A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice.
J Leukoc Biol
; 80(4): 897-904, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16888084
14.
Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells.
Melanoma Res
; 16(1): 11-22, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16432451
15.
Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.
J Med Chem
; 48(1): 171-9, 2005 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15634011
16.
Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo.
PLoS One
; 10(11): e0141330, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26555695
17.
Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties.
J Med Chem
; 46(7): 1123-6, 2003 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12646021
18.
Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.
J Med Chem
; 45(18): 3829-35, 2002 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-12190306
19.
Estimating the prevalence of opioid diversion by "doctor shoppers" in the United States.
PLoS One
; 8(7): e69241, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23874923
20.
Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.
J Med Chem
; 56(23): 9586-600, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24182233