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1.
Am J Otolaryngol ; 45(4): 104337, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38677145

RESUMO

OBJECTIVE: To describe an AI model to facilitate adult cochlear implant candidacy prediction based on basic demographical data and standard behavioral audiometry. METHODS: A machine-learning approach using retrospective demographic and audiometric data to predict candidacy CNC word scores and AzBio sentence in quiet scores was performed at a tertiary academic center. Data for the model were derived from adults completing cochlear implant candidacy testing between January 2011 and March 2023. Comparison of the prediction model to other published prediction tools and benchmarks was performed. RESULTS: The final dataset included 770 adults, encompassing 1045 AzBio entries, and 1373 CNC entries. Isophoneme scores and word recognition scores exhibited strongest importance to both the CNC and AzBio prediction models, followed by standard pure tone average and low-frequency pure tone average. The mean absolute difference between the predicted and actual score was 15 percentage points for AzBio sentences in quiet and 13 percentage points for CNC word scores, approximating anticipated test-retest constraints inherent to the variables incorporated into the model. Our final combined model achieved an accuracy of 87 % (sensitivity: 90 %; precision: 80 %). CONCLUSION: We present an adaptive AI model that predicts adult cochlear implant candidacy based on routine behavioral audiometric and basic demographical data. Implementation efforts include a public-facing online prediction tool and accompanying smartphone program, an embedded notification flag in the electronic medical record to alert providers of potential candidates, and a program to retrospectively engage past patients who may be eligible for cochlear implantation based on audiogram results.


Assuntos
Implante Coclear , Implantes Cocleares , Humanos , Masculino , Pessoa de Meia-Idade , Feminino , Adulto , Estudos Retrospectivos , Implante Coclear/métodos , Idoso , Audiometria/métodos , Aprendizado de Máquina , Seleção de Pacientes , Adulto Jovem , Idoso de 80 Anos ou mais
2.
Am J Otolaryngol ; 45(4): 104339, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38677146

RESUMO

OBJECTIVE: To examine current practices and opinions of cochlear implant (CI) providers with respect to post-implantation auditory training. METHODS: A survey was submitted to the American Cochlear Implant Alliance membership that reviewed current practice and opinions with respect to post-implantation auditory training for adult CI recipients. MAIN OUTCOME MEASURES: Review of respondent practice, center volume, role on CI team, and current usage and opinions surrounding auditory training, including resources used and schedule of use. RESULTS: Most (79 %) of the 79 CI providers surveyed reported working at academic centers, 34 % at high-volume centers (>150 CIs/year), and 38 % were surgeons. Nearly all (99 %) respondents recommend auditory training for new adult CI recipients. Just over half (52 %) provide auditory training resources to the patient in the form of a broad list of patient-directed exercises from which a patient could select. A specific training resource, generally a computer-based auditory training program (e.g., AngelSound™), is recommended to patients by 30 % of the respondents. Regarding timing of rehabilitation, median preferred start time was 0 months (interquartile range [IQR] 0-1) post-activation. Sessions were preferably performed for a median of 3 h per week (IQR 2-4) and continued for a median of 12 months (IQR 6-12). Recommendations for auditory training were fairly consistent between surgeon and non-surgeon providers and by center volume. Non-surgeons more often had specific recommendations on training resources, benefits of music, and training condition (e.g., contralateral ear plugged). CONCLUSIONS: Despite a lack of clinical guidelines for adult post-implantation auditory training, a cross-sectional survey of providers' current practices and opinions demonstrates that these services are widely recommended and regarded as valuable. Training is almost universally patient-directed and believed to be most beneficial if started soon after activation. Interestingly, specific recommendations for which training approaches to use are not common, suggesting a gap in provider knowledge of which resources are most efficacious.


Assuntos
Implante Coclear , Implantes Cocleares , Humanos , Adulto , Inquéritos e Questionários , Padrões de Prática Médica , Educação de Pacientes como Assunto , Masculino , Feminino
3.
Am J Otolaryngol ; 45(2): 104192, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38104470

RESUMO

PURPOSE: Radiographic review of pathologies that associate with third window syndrome. METHODS: Case series and literature review. RESULTS: Eight unique third window conditions are described and illustrated, including superior, lateral, and posterior semicircular canal dehiscence; carotid-cochlear, facial-cochlear, and internal auditory canal-cochlear dehiscence, labyrinthine erosion from endolymphatic sac tumor, and enlarged vestibular aqueduct. CONCLUSION: The present study highlights the characteristic imaging features and symptoms to differentiate third window pathologies for expedient diagnosis and management planning.


Assuntos
Perda Auditiva Neurossensorial , Doenças do Labirinto , Deiscência do Canal Semicircular , Aqueduto Vestibular , Humanos , Doenças do Labirinto/diagnóstico por imagem , Doenças do Labirinto/patologia , Perda Auditiva Neurossensorial/patologia , Aqueduto Vestibular/patologia , Cóclea/diagnóstico por imagem , Cóclea/patologia , Canais Semicirculares/diagnóstico por imagem , Canais Semicirculares/patologia
4.
Am J Otolaryngol ; 44(2): 103743, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36580740

RESUMO

PURPOSE: To describe the presentation, diagnosis, and management of chronic otitis media recidivism after subtotal petrosectomy and ear canal closure (STP). MATERIALS AND METHODS: Patients with temporal bone pathology detected during follow-up after STP were identified in the electronic medical record. Pertinent clinical details regarding surveillance plan, presentation, imaging findings, and revision surgery were collected and analyzed. RESULTS: A total of 10 patients were identified with recurrent or persistent pathology after STP. The median time to detection was 46 months (IQR 24-84). Five patients (50 %) had non-specific symptomatology, 4 patients (40 %) were completely asymptomatic, and 1 patient (10 %) was asymptomatic outside of two instances of mastoiditis with cochlear implant device infection treated with incision and drainage. One patient (10 %) was noted to have proptosis on examination, but no other patients had objective signs of disease at detection of disease recidivism. Nine (90 %) patients had pathology identified on preoperative imaging. All patients underwent revision surgery, with identification of cholesteatoma in 8 cases (80 %) and cholesterol granuloma in 2 cases (20 %). Extensive disease was noted in 6 patients (60 %), all of whom followed-up greater than 3 years from surgery. All patients tolerated revision surgery without complication. CONCLUSIONS: Recidivistic disease often remains clinically silent for extended periods of time after STP. Planned follow-up - with imaging or second look surgery - to facilitate early detection should be considered. Undetected disease recurrence or development may result in morbidity in a proportion of patients if surveillance is not performed.


Assuntos
Colesteatoma da Orelha Média , Implante Coclear , Implantes Cocleares , Otite Média , Reincidência , Humanos , Meato Acústico Externo/cirurgia , Implante Coclear/métodos , Otite Média/cirurgia , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Estudos Retrospectivos , Colesteatoma da Orelha Média/cirurgia , Doença Crônica
5.
Am J Otolaryngol ; 44(5): 103952, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37329696

RESUMO

OBJECTIVE: To report 20 years of natural history data for a facial paraganglioma and provide a comprehensive review of the existing literature. PATIENT: 81-year-old female with a remote history of cardiac arrest while under anesthesia who elected to observe her facial paraganglioma for 20 years. INTERVENTIONS: Observation, clinical documentation, radiographic surveillance. MAIN OUTCOME MEASURES: Tumor progression, patient symptomatology, and review of management options. RESULTS: The initial presentation of the facial paraganglioma was facial spasm. Over the course of observation, symptoms progressed to include complete facial nerve paralysis, pulsatile tinnitus, and otalgia on the affected side. Radiologic surveillance demonstrated incremental growth and erosion of surrounding structures, including the posterior external auditory canal, stylomastoid foramen, and lateral semicircular canal with near-dehiscence. Twenty-four cases of facial paraganglioma were identified in the extended literature search and are summarized herein. CONCLUSIONS: This unique case contributes to the scarce literature surrounding facial paragangliomas by reporting the extended natural history of this disease.


Assuntos
Neoplasias dos Nervos Cranianos , Doenças do Nervo Facial , Paralisia Facial , Paraganglioma , Humanos , Feminino , Idoso de 80 Anos ou mais , Neoplasias dos Nervos Cranianos/diagnóstico , Paraganglioma/diagnóstico por imagem , Paraganglioma/cirurgia , Doenças do Nervo Facial/etiologia , Doenças do Nervo Facial/complicações , Paralisia Facial/etiologia , Osso Temporal/patologia
6.
J Transl Med ; 20(1): 56, 2022 01 29.
Artigo em Inglês | MEDLINE | ID: mdl-35093126

RESUMO

BACKGROUND: Chronic tinnitus affects millions of people globally and constitutes the most commonly compensated disability among military service members in the United States. Existing treatment options largely surround helping patients cope with their disease as opposed to directly suppressing tinnitus perception. The current study investigated the efficacy of electrical stimulation of the cochlea on chronic disabling tinnitus. METHODS: In this single-arm, open-label clinical trial, 22 adult subjects with severe-range asymmetric or unilateral non-pulsatile tinnitus underwent electrical stimulation of the cochlea through use of an extra-cochlear electrode positioned on the cochlear promontory. Each subject underwent 3 stimulation treatments over 3 weeks at 7-day intervals. Tinnitus severity was determined by Tinnitus Handicap Inventory (THI), Tinnitus Functional Index (TFI), and Tinnitus Visual Analog Scale (VAS). Inclusion criteria required subjects have no worse than moderate sensorineural hearing loss determined by pre-enrollment audiometric testing. The primary outcome was nadir post-treatment THI scores, obtained at seven timepoints following electrical stimulation, with clinically significant improvement defined as a decrease of ≥ 7. RESULTS: All 22 (100%) subjects experienced clinically significant improvement in the THI during the study period with a mean decrease in scores of - 31 (95% CI - 38 to - 25) from a baseline of 48. Twenty (91%) experienced clinically significant improvement detectable on at least two of the three tinnitus survey instruments and 17 (77%) experienced clinically significant improvement detectable on all three survey instruments (i.e., THI, TFI, and VAS). Eight (36%) subjects reported either complete (THI of 0; n = 3) or near-complete (THI 1-4; n = 5) suppression of their tinnitus following a stimulation session. Thirteen (59%) subjects reported a nadir following stimulation at or below the threshold for "no or slight handicap" on the THI (≤ 16). No adverse events were observed. CONCLUSIONS: These findings establish the foundation for the development of an extra-cochlear implantable device that delivers electrical stimulation to the cochlea for the treatment of disabling tinnitus. For patients considering device implantation, trans-tympanic cochlear promontory stimulation can facilitate patient selection. Trial Registration ClinicalTrials.gov Identifier: NCT03759834. URL: https://clinicaltrials.gov/ct2/show/NCT03759834.


Assuntos
Implante Coclear , Implantes Cocleares , Zumbido , Adulto , Cóclea , Estimulação Elétrica , Humanos , Zumbido/cirurgia , Resultado do Tratamento
7.
Ear Hear ; 43(6): 1605-1619, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35994570

RESUMO

The indications for cochlear implantation have expanded to include individuals with profound sensorineural hearing loss in the impaired ear and normal hearing (NH) in the contralateral ear, known as single-sided deafness (SSD). There are additional considerations for the clinical assessment and management of adult cochlear implant candidates and recipients with SSD as compared to conventional cochlear implant candidates with bilateral moderate to profound sensorineural hearing loss. The present report reviews the current evidence relevant to the assessment and management of adults with SSD. A systematic review was also conducted on published studies that investigated outcomes of cochlear implant use on measures of speech recognition in quiet and noise, sound source localization, tinnitus perception, and quality of life for this patient population. Expert consensus and systematic review of the current literature were combined to provide guidance for the clinical assessment and management of adults with SSD.


Assuntos
Implante Coclear , Implantes Cocleares , Surdez , Perda Auditiva Neurossensorial , Perda Auditiva Unilateral , Localização de Som , Percepção da Fala , Adulto , Humanos , Qualidade de Vida , Perda Auditiva Neurossensorial/cirurgia , Surdez/reabilitação , Perda Auditiva Unilateral/reabilitação , Resultado do Tratamento
8.
Am J Otolaryngol ; 43(5): 103495, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35581105

RESUMO

Medical education is rapidly evolving. The historical reliance on textbook reading is being increasingly replaced by trainees in favor of using non-traditional platforms such as podcasts, videos, and app-based learning. Neuroscience research on human learning has demonstrated superior long-term retention when the synergistic principles of spaced repetition and active recall are employed. Spaced repetition entails the repeated exposure to learned material over successive iterations, whereas active recall involves the intentional reconstructive process of retrieving previously learned material, often through prompting (e.g., answering open-ended questions without multiple choice answers), rather than passively reviewing previously learned information (e.g., re-reading a textbook chapter). These concepts have revolutionized medical student education, with use of open-source spaced repetition platforms, such as Anki, and question banks becoming ubiquitous. Paralleling educational platforms within otolaryngology are emerging. Headmirror's OtoRecall app provides a free, peer-reviewed, open-access option for otolaryngology trainees to harness the power of these learning principles.


Assuntos
Otolaringologia , Estudantes de Medicina , Competência Clínica , Avaliação Educacional , Humanos , Aprendizagem , Otolaringologia/educação
9.
Am J Otolaryngol ; 43(5): 103575, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35952533

RESUMO

OBJECTIVE: Otolaryngology resident learning has historically relied on didactic lectures, textbook reading, and practical hands-on patient care. However, evidence suggests that an increasing proportion of residents in other specialties are deviating from this paradigm. This work aims to characterize otolaryngology residents' current asynchronous learning practices (i.e., personal learning outside of didactics and patient care). METHODS: A thirteen-question survey of otolaryngology residents in the United States was performed from 10/1/2020-12/1/2020 assessing demographics, educational resource utilization, and educational resource preference. RESULTS: Nearly all (99 %) respondents reported engaging with educational materials outside of didactics and case prep. Textbook reading comprised 27 % of residents' total study time, with additional time split between board-review book reading (20 %), searching the web (18 %), watching online videos (15 %), and listening to podcasts (10 %). Residents' highest ranked resources were videos, board-review books, textbooks, podcasts, and recorded lectures. Among electronic and multimedia resources, more than half of residents used the following resources: Iowa Head and Neck Protocols (91 %), Board Vitals (75 %), UpToDate (60 %), YouTube (57 %), Google (56 %), and Headmirror (54 %). CONCLUSION: Current otolaryngology resident learning involves substantial use of asynchronous learning, including videos, web-based learning, and podcasts, which currently outpace traditional textbook- and didactic-based education. This underscores the need to consider a paradigm shift within academic otolaryngology education away from textbooks and other tradition media to the generation of high-quality multimedia resources for resident learning.


Assuntos
Internato e Residência , Otolaringologia , Humanos , Aprendizagem , Otolaringologia/educação , Inquéritos e Questionários , Estados Unidos
10.
Am J Otolaryngol ; 43(3): 103461, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35427937

RESUMO

OBJECTIVE: Management of ectopic lingual thyroid (ELT) must balance the morbidity of disease with the morbidity of treatment. We investigate clinical outcomes associated with modern treatment options and analyze the role of transoral surgery in the treatment algorithm for ELT. METHODS: This was a retrospective chart review of ELT patients treated at a tertiary care center from 1/1/1979 to 12/31/2019. In addition, a systematic review of the literature from 1979 to 2021 for reports of ELT was performed. Symptoms defined as high-risk were dysphagia, dysphonia, dyspnea, neck swelling, bleeding, and obstructive sleep apnea (OSA). RESULTS: 36 patients within the institutional cohort (IC) and 224 cases in the systematic review (SRC) met criteria. The most common presenting symptoms for both cohorts were dysphagia, globus sensation, and dysphonia. One third of each cohort were hypothyroid, while 3% (n = 1) and 9% (n = 21) of the IC and SRC, respectively, had clinical suspicion of malignancy at presentation. 27% (n = 10) of the IC and 55% (n = 121) of the SRC underwent surgical therapy. There was a 4% (3/72) transoral bleed rate for all patients undergoing transoral surgery. Other reported complications were minor. There were no tracheostomies, and no deaths. Among observed, medically treated, and surgically treated patients, symptoms improved during follow up for 43% or 68% in the IC and SRC, respectively. Following surgery, symptoms improved or resolved for 86% or 93% in the IC and SRC, respectively. CONCLUSIONS: Asymptomatic ELTs with no concern for malignancy can be managed with observation. Patients with mild symptoms or hypothyroidism may trial thyroid suppressive therapy or RAI. RAI can be considered for patients with high-risk symptoms. For patients with symptoms resistant to conservative therapy, concern for malignancy or high-risk symptoms not conducive to RAI, surgery should be considered. Transoral approaches offer acceptable morbidity, and most patients experience resolution of symptoms following this approach.


Assuntos
Transtornos de Deglutição , Disfonia , Hipotireoidismo , Tireoide Lingual , Transtornos de Deglutição/etiologia , Humanos , Tireoide Lingual/cirurgia , Estudos Retrospectivos , Língua/patologia
11.
Am J Otolaryngol ; 43(1): 103208, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34536917

RESUMO

BACKGROUND: A variety of neurosensory symptoms including tinnitus have been associated with COVID-19 infection. While most cases of tinnitus are associated with hearing loss, here we report a case of severe tinnitus following COVID-19 infection with normal thresholds through 8000 Hz. CASE REPORT: A 49-year-old male presented with new onset severe tinnitus following COVID-19 infection. Tinnitus was bilateral, constant and nonpulsatile. Audiometric evaluation revealed normal threshold through 8000 Hz, with mild hearing loss at 16,000 Hz. Conservative measures including masking strategies failed to mitigate symptoms. A trial of gabapentin 300 mg twice per day improved tinnitus with no notable side effects. CONCLUSION: This patient may represent a subpopulation of patients who suffer from severe tinnitus following COVID-19 infection in the setting of largely normal hearing. The pathophysiology may be distinct from the more common hearing loss associated tinnitus and perhaps neuromodulators may play a larger role in mitigating tinnitus in this patient subset.


Assuntos
COVID-19/complicações , Antagonistas de Aminoácidos Excitatórios/uso terapêutico , Gabapentina/uso terapêutico , Zumbido/tratamento farmacológico , Zumbido/virologia , Humanos , Masculino , Pessoa de Meia-Idade , SARS-CoV-2
12.
Am J Otolaryngol ; 43(2): 103304, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34896938

RESUMO

OBJECTIVE: There is a void in the literature describing reliable surgical landmarks that aid in the dissection of the facial recess in the absence of skeletonizing the mastoid segment of the facial nerve. The posterior ligament of the incus is a readily distinguishable "white dot" along the incus buttress that has been used to guide dissection in a safe and efficient manner. The goal of our study is to describe a surgical approach that utilizes this surgical landmark to drill the facial recess and to take anatomical measurements demonstrating the safety and reliability of this approach. MATERIALS AND METHODS: After cortical mastoidectomies were performed in 10 cadaveric temporal bones, the white dot was identified at the junction of short process of the incus and the incus buttress. Using the white dot for anatomical reference, a 2 mm diamond drill bit was used to open the facial recess without first identifying the facial nerve or chorda tympani nerve. After photographs were taken, the facial and chorda tympani nerves were definitively identified and skeletonized to delineate the confines of the facial recess. Photographs were once again acquired in a consistent manner for comparison. Finally, calibrated anatomic measurements were acquired from the 10 distinct image sets. RESULTS: The facial recess was successfully drilled in 10 temporal bones using the posterior ligament as a surgical landmark without injury to the chorda tympani or facial nerve. The median angle taken from the axis of the short process of the incus to the facial nerve - chorda tympani junction was 139.2° (IQR 136.8-141). At the widest point in the facial recess, median distances anterior and posterior to an imaginary line connecting the white dot to the facial nerve - chorda tympani junction were 1.6 mm (IQR 1.5-1.7) and 1.6 mm (IQR 1.6-1.7; p = 0.57), indicating at this point, the white dot reference reliably bisects the facial recess width. Similarly, at the level of the round window niche, median anterior and posterior distances from an imaginary line connecting the white dot to the facial nerve - chorda tympani junction were 1.1 mm (IQR 1.1-1.3) and 1.3 mm (IQR 1.1-1.7; p = 0.07), respectively, once again demonstrating the white dot reliably bisecting the facial recess. CONCLUSIONS: The white dot, representing the posterior ligament of the incus, is a reliable surgical landmark that aids in safe and efficient drilling of the facial recess without first skeletonizing the facial nerve.


Assuntos
Implante Coclear , Bigorna , Nervo da Corda do Tímpano/cirurgia , Implante Coclear/métodos , Nervo Facial/cirurgia , Humanos , Bigorna/cirurgia , Ligamentos/cirurgia , Reprodutibilidade dos Testes , Janela da Cóclea/cirurgia , Osso Temporal/cirurgia
13.
Am J Otolaryngol ; 43(2): 103348, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34973661

RESUMO

Capillary hemangiomas are benign vascular lesions that are common in head and neck, but hemangiomas of jugular foramen and temporal bone are rare with only a few cases reported in the literature. We present a case report of this rare disease entity highlighting the subtle radiographic nuances that can benefit clinicians when encountered with similar unusual clinical scenario. Although radiographic features of capillary hemangioma can be distinctive, they are not specific. In this case, the lack of significant involvement of the jugular bulb and the absence of the typical pattern of osseous erosion of the jugular carotid spine led to the alternative diagnosis of a rare capillary hemangioma of the jugular foramen.


Assuntos
Hemangioma Capilar , Forâmen Jugular , Paraganglioma , Hemangioma Capilar/diagnóstico por imagem , Hemangioma Capilar/cirurgia , Humanos , Osso Temporal/patologia
14.
J Acoust Soc Am ; 151(3): 1913, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35364910

RESUMO

Standard clinical protocols require hearing protection during magnetic resonance imaging (MRI) for patient safety. This investigation prospectively evaluated the auditory function impact of acoustic noise exposure during a 3.0T MRI in healthy adults. Twenty-nine participants with normal hearing underwent a comprehensive audiologic assessment before and immediately following a clinically indicated head MRI. Appropriate hearing protection with earplugs (and pads) was used per standard of practice. To characterize noise hazards, current sound monitoring tools were used to measure levels of pulse sequences measured. A third audiologic test was performed if a significant threshold shift (STS) was identified at the second test, within 30 days post MRI. Some sequences produced high levels (up to 114.5 dBA; 129 dB peak SPL) that required hearing protection but did not exceed 100% daily noise dose. One participant exhibited an STS in the frequency region most highly associated with noise-induced hearing loss. No participants experienced OSHA-defined STS in either ear. Overall, OAE measures did not show evidence of changes in cochlear function after MRI. In conclusion, hearing threshold shifts associated with hearing loss or OAE level shifts reflecting underlying cochlear damage were not detected in any of the 3.0T MRI study participants who used the current recommended hearing protection.


Assuntos
Surdez , Perda Auditiva Provocada por Ruído , Dispositivos de Proteção das Orelhas , Audição , Perda Auditiva Provocada por Ruído/etiologia , Perda Auditiva Provocada por Ruído/prevenção & controle , Humanos , Imageamento por Ressonância Magnética/efeitos adversos , Adulto Jovem
15.
Int J Audiol ; 61(6): 520-525, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-34278935

RESUMO

OBJECTIVE: This study aims to determine if early device activation can influence cochlear implant electrode impedances by providing electrical stimulation within hours after cochlear implant surgery. DESIGN: Electrode impedances were measured intraoperatively, at device activation, and one-month after device activation in three groups: users whose devices were activated (1) on the same day (Same Day), (2) the next day (Next Day), and (3) 10-14 days (Standard), after cochlear implant surgery. STUDY SAMPLE: Electrode impedances are reported in fifty-one patients implanted with a Cochlear™ Nucleus® Cochlear Implant. RESULTS: Compared to intraoperative levels, impedances dropped within hours for the Same Day activation group (p < 0.001) and continued dropping on the next day after surgery (p < 0.001). Similarly, electrode impedances were significantly (p < 0.001) lower at device activation for the Next Day group as compared to their intraoperative measurements. For Standard activation, impedances increased significantly from intraoperative levels, prior to device activation (p < 0.001). One-month after initial activation, impedances were not statistically different between the Same Day, Next Day, and Standard activation groups. CONCLUSIONS: Early device activation does not influence long-term impedances in a clinically meaningful manner.


Assuntos
Implante Coclear , Implantes Cocleares , Cóclea , Impedância Elétrica , Estimulação Elétrica , Humanos
16.
J Neurooncol ; 153(2): 273-281, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33907967

RESUMO

PURPOSE: To clarify the need for post-operative radiation treatment in skull base chondrosarcomas (SBCs). METHODS: A retrospective analysis of patients with grade I or II SBC. Patients were divided according to post-surgical treatment strategies: (A) planned upfront radiotherapy and (B) watchful waiting. Tumor control and survival were compared between the treatment groups. The median follow-up after resection was 105 months (range, 9-376). RESULTS: Thirty-two patients (Grade 1, n = 16; Grade 2, n = 16) were included. The most frequent location was petroclival (21, 64%). A gross total resection (GTR) was achieved in 11 patients (34%). Fourteen (44%) underwent upfront radiotherapy (group A) whereas 18 (56%) were followed with serial MRI alone (group B). The tumor control rate for the entire group was 77% and 69% at 10- and 15-year, respectively. Upfront radiotherapy (P = 0.25), extent of resection (P = 0.11) or tumor grade (P = 0.83) did not affect tumor control. The majority of Group B patients with recurrent tumors (5/7) obtained tumor control with repeat resection (n = 2), salvage radiotherapy (n = 2), or a combination of both (n = 1). The 10-year disease-specific survival was 95% with no difference between the group A and B (P = 0.50). CONCLUSION: For patients with grade I/II SBC, a reasonable strategy is deferral of radiotherapy after maximum safe resection until tumor progression or recurrence. At that time, most patients can be successfully managed with salvage radiotherapy or surgery. Late recurrences may occur, and life-long follow-up is advisable.


Assuntos
Condrossarcoma , Neoplasias da Base do Crânio , Condrossarcoma/diagnóstico por imagem , Condrossarcoma/radioterapia , Condrossarcoma/cirurgia , Seguimentos , Humanos , Estadiamento de Neoplasias , Estudos Retrospectivos , Base do Crânio , Neoplasias da Base do Crânio/diagnóstico por imagem , Neoplasias da Base do Crânio/cirurgia , Resultado do Tratamento
17.
Int J Gynecol Cancer ; 31(4): 518-523, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-32920534

RESUMO

INTRODUCTION: Stage IVA cervical cancer is an uncommon diagnosis. The course of the disease and the complications of treatment are not well characterized. The goal of this study was to report treatment outcomes of patients with stage IVA cervical cancer. METHODS: A single institution retrospective review was carried out of all patients treated for stage IVA cervical cancer from January 2008 to July 2017. Patients were clinically staged using the International Federation of Gynecology and Obstetrics (FIGO) 2009 staging criteria for cervical cancer. Inclusion criteria were patients with stage IVA cervical cancer of any histologic subtype, including patients with evidence of para-aortic lymph node involvement, treated at the institution during this time period. Overall survival and progression free survival were calculated using the Kaplan-Meyer method. Comparisons between survival were done using the Cox proportional hazards regression model and the log rank test. RESULTS: We identified 25 patients with stage IVA cervical cancer. Mean age at diagnosis was 54 years (range 27-77). Squamous cell carcinoma was the histologic diagnosis in 24 of 25 patients (96%), with 1 case of small cell carcinoma (4%). 21 patients completed a full course of radiation. The median overall survival for patients who completed their treatment was 60 months (range 3-136), with a 2 year overall survival of 63%. The median progression free survival was 27 months (range 0-125), with a 2 year progression free survival of 40%. 11 of 25 patients (44%) developed fistulas during the course of their disease, and 55% of these were complex fistulas. 19 of 25 (76%) patients had a percutaneous nephrostomy for either hydronephrosis or diversion of vesicovaginal fistula. 111 unplanned admissions occurred among the 25 patients, and infections of the urinary tract was implicated in 46 (41%) of these. The cohort had a total of 92 emergency department visits, with pain control (36%) and medication refills (15%) being the most common presentations. DISCUSSION: Patients with stage IVA cervical cancer may have substantial long term survival, although the sequelae of disease and treatment is associated with significant morbidity. Symptoms of fistula, percutaneous nephrostomy complications, and chronic pain present unique issues that require extensive supportive care.


Assuntos
Neoplasias do Colo do Útero/complicações , Neoplasias do Colo do Útero/terapia , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Resultado do Tratamento
18.
Acta Neurochir (Wien) ; 163(8): 2199-2207, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33471207

RESUMO

BACKGROUND: Vestibular schwannomas (VS) present at variable size with heterogeneous symptomatology. Modern treatment paradigms for large VS include gross total resection, subtotal resection (STR) in combination with observation, and/or radiation to achieve optimal function preservation, whereas treatment is felt to be both easier and safer for small VS. The objective is to better characterize the presentation and surgical outcomes of large and small VS. METHODS: We collected data of patients who had surgically treated VS with a posterior fossa diameter of 4.0 cm or larger (large tumor group, LTG) and smaller than 1.0 cm in cisternal diameter (small tumor group, STG). Statistical significance was defined as p < 0.05. RESULTS: LTG included 48 patients (average tumor size: 44.9 mm) and STG 38 (7.9 mm). Patients in STG presented more frequently with tinnitus and sudden hearing loss. Patients in LTG underwent more STR than STG (50.0% vs. 2.6%, p < 0.0001). LTG had more complications (31.3% vs. 13.2%, p = 0.049). Postoperative facial nerve function in STG was significantly better than LTG. STG had better hearing preoperatively (p < 0.0001) and postoperatively than LTG (p = 0.0002). Postoperative headache was more common in STG (13.2% vs. 2.1%, p = 0.045). The rate of recurrence/progression needing treatment was not statistically different between the groups (12.5% in LTG vs. 7.9% in STG, p = 0.49). Those patients who required periprocedural cerebrospinal fluid diversion had higher risk of infection (20.8% vs 4.8%, p = 0.022). CONCLUSION: Large and small VS present differently. LTG showed more unsatisfactory outcomes in facial nerve function and postoperative hearing despite maximal efforts undertaken toward function-preservation strategy; however, similar tumor control was achieved.


Assuntos
Neuroma Acústico , Cefaleia , Audição , Humanos , Recidiva Local de Neoplasia , Neuroma Acústico/cirurgia , Procedimentos Neurocirúrgicos
19.
Am J Otolaryngol ; 42(4): 102981, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33621763

RESUMO

OBJECTIVE: Spontaneous otogenic pneumatocele is a rare entity resulting from a pressure gradient between a dehiscent temporal bone and the intracranial space. Secondary infection can ensue in patients with concurrent otomastoiditis. The current study discusses the clinical presentation and imaging characteristics of two cases of secondarily infected otogenic pneumatoceles. STUDY DESIGN: Case series. RESULTS: Two patients were diagnosed with a temporal lobe abscess in the setting of otogenic pneumatocele. Diagnosis was aided by both CT and MRI demonstrating a diffusion restricting lesion within brain parenchyma in association with free air in close proximity to an underlying tegmen defect. CONCLUSION: Prompt diagnosis of a secondarily infected otogenic pneumatocele with CT and MRI allows for surgical drainage with closure of the tegmen defect to prevent further complications and recurrence.


Assuntos
Imageamento por Ressonância Magnética , Pneumocefalia/diagnóstico por imagem , Pneumocefalia/etiologia , Tomografia Computadorizada por Raios X , Abscesso Encefálico/diagnóstico por imagem , Abscesso Encefálico/etiologia , Drenagem , Humanos , Hipertensão Intracraniana/complicações , Masculino , Mastoidite/etiologia , Pessoa de Meia-Idade , Pneumocefalia/cirurgia , Osso Temporal , Lobo Temporal
20.
Am J Otolaryngol ; 42(6): 103144, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34171699

RESUMO

OBJECTIVE: Report an association between congenital stapes footplate fixation (CSFF) and radiological absence of the pyramidal eminence and stapedial tendon. PATIENTS: Children and adults with intraoperatively confirmed CSFF and an absent stapedial tendon. INTERVENTIONS: Computed tomography (CT); exploratory tympanotomy with stapedotomy. MAIN OUTCOME MEASURES: Absence of a pyramidal eminence and stapedial tendon aperture identified on preoperative CT that was confirmed intraoperatively. RESULTS: Eight patients with intraoperative confirmation of CSFF and absent stapedial tendon were retrospectively identified. The average preoperative bone conduction and air conduction pure tone averages were 19.6 dB (SD 15.6 dB) and 55.9 dB (SD 23.6 dB), respectively. The average air-bone gap was 36.3 dB (SD 17.9 dB) preoperatively. In the seven patients who underwent preoperative CT, all were consistently identified to have an absent or hypoplastic pyramidal eminence and absent stapedial tendon aperture at the pyramidal eminence. In six cases, the stapedial footplate appeared normal, while in one case the footplate appeared abnormal which correlated with severe facial nerve prolapse observed intraoperatively. All eight cases underwent exploratory tympanotomy and demonstrated intraoperative stapes footplate fixation, absent stapedial tendon and either absent or hypoplastic pyramidal eminence, which correlated with preoperative CT findings. CONCLUSIONS: This study identifies a clinically pragmatic association between an absent pyramidal eminence identified on high-resolution CT and the diagnosis of CSFF. In a condition that otherwise generally lacks distinctive radiological features, the absence of a pyramidal eminence on CT in a patient with nonprogressive, congenital conductive hearing loss may strengthen clinical suspicion for CSFF.


Assuntos
Perda Auditiva Condutiva/etiologia , Perda Auditiva Condutiva/cirurgia , Estapédio/anormalidades , Estapédio/cirurgia , Cirurgia do Estribo/métodos , Tendões/anormalidades , Tendões/cirurgia , Adolescente , Adulto , Condução Óssea , Criança , Doenças do Nervo Facial/complicações , Feminino , Perda Auditiva Condutiva/congênito , Perda Auditiva Condutiva/diagnóstico por imagem , Humanos , Período Intraoperatório , Masculino , Prolapso , Estudos Retrospectivos , Estapédio/diagnóstico por imagem , Estapédio/fisiopatologia , Tendões/diagnóstico por imagem , Tendões/fisiopatologia , Tomografia Computadorizada por Raios X , Adulto Jovem
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