Isotherm Theoretical Study of the AlxGa1-xAsySb1-y Quaternary Alloy Using the Regular Solution Approximation for Its Possible Growth via Liquid-Phase Epitaxy at Low Temperatures.

This work presents the theoretical calculation of isotherm diagrams for quaternary alloys of III-V semiconductor compounds with the form IIIxIII1-xVyV1-y. In particular, the isotherm diagrams for the AlxGa1-xAsySb1-y quaternary alloy at low temperatures were calculated (500 °C, 450 °C, 400 °C, and 350 °C). The AlxGa1-xAsySb1-y quaternary alloy was formed from four binary compounds such as GaAs, AlAs, AlSb, and GaSb, all with direct bandgaps. The regular solution approximation was used to find the quaternary isotherm diagrams, represented in four linearly independent equations, which were solved using Parametric Technology Corporation Mathcad 14.0 software for different arsenic and antimony atomic fractions. The results support the possible growth of layers via liquid-phase epitaxy in a range of temperatures from 500 °C to 350 °C, where the crystalline quality could be improved at low temperatures. These semiconductor layers could have applications for optoelectronic devices in photonic communications, thermophotovoltaic systems, and microwave devices with good crystalline quality.

Antibodies to Aedes aegypti D7L salivary proteins as a new serological tool to estimate human exposure to Aedes mosquitoes.

Introduction: Aedes spp. are the most prolific mosquito vectors in the world. Found on every continent, they can effectively transmit various arboviruses, including the dengue virus which continues to cause outbreaks worldwide and is spreading into previously non-endemic areas. The lack of widely available dengue vaccines accentuates the importance of targeted vector control strategies to reduce the dengue burden. High-throughput tools to estimate human-mosquito contact and evaluate vector control interventions are lacking. We propose a novel serological tool that allows rapid screening of human cohorts for exposure to potentially infectious mosquitoes. Methods: We tested 563 serum samples from a longitudinal pediatric cohort study previously conducted in Cambodia. Children enrolled in the study were dengue-naive at baseline and were followed biannually for dengue incidence for two years. We used Western blotting and enzyme-linked immunosorbent assays to identify immunogenic Aedes aegypti salivary proteins and measure total anti-Ae. aegypti IgG. Results: We found a correlation (rs=0.86) between IgG responses against AeD7L1 and AeD7L2 recombinant proteins and those to whole salivary gland homogenate. We observed seasonal fluctuations of AeD7L1+2 IgG responses and no cross-reactivity with Culex quinquefasciatus and Anopheles dirus mosquitoes. The baseline median AeD7L1+2 IgG responses for young children were higher in those who developed asymptomatic versus symptomatic dengue. Discussion: The IgG response against AeD7L1+2 recombinant proteins is a highly sensitive and Aedes specific marker of human exposure to Aedes bites that can facilitate standardization of future serosurveys and epidemiological studies by its ability to provide a robust estimation of human-mosquito contact in a high-throughput fashion.

Nanoelectrochemistry in electrochemical phase transition reactions.

Electrochemical phase transition is important in a range of processes, including gas generation in fuel cells and electrolyzers, as well as in electrodeposition in battery and metal production. Nucleation is the first step in these phase transition reactions. A deep understanding of the kinetics, and mechanism of the nucleation and the structure of the nuclei and nucleation sites is fundamentally important. In this perspective, theories and methods for studying electrochemical nucleation are briefly reviewed, with an emphasis on nanoelectrochemistry and single-entity electrochemistry approaches. Perspectives on open questions and potential future approaches are also discussed.

Obtaining of Mg-Zn Co-Doped GaN Powders via Nitridation of the Ga-Mg-Zn Metallic Solution and Their Structural and Optical Properties.

Mg-Zn co-dopedGaN powders via the nitridation of a Ga-Mg-Zn metallic solution at 1000 °C for 2 h in ammonia flow were obtained. XRD patterns for the Mg-Zn co-dopedGaN powders showed a crystal size average of 46.88 nm. Scanning electron microscopy micrographs had an irregular shape, with a ribbon-like structure and a length of 8.63 µm. Energy-dispersive spectroscopy showed the incorporation of Zn (Lα 1.012 eV) and Mg (Kα 1.253 eV), while XPS measurements showed the elemental contributions of magnesium and zinc as co-dopant elements quantified in 49.31 eV and 1019.49 eV, respectively. The photoluminescence spectrum showed a fundamental emission located at 3.40 eV(364.70 nm), which was related to band-to-band transition, besides a second emission found in a range from 2.80 eV to 2.90 eV (442.85-427.58 nm), which was related to a characteristic of Mg-doped GaN and Zn-doped GaN powders. Furthermore, Raman scattering demonstrated a shoulder at 648.05 cm-1, which could indicate the incorporation of the Mg and Zn co-dopants atoms into the GaN structure. It is expected that one of the main applications of Mg-Zn co-doped GaN powders is in obtaining thin films for SARS-CoV-2 biosensors.

Pielonefritis xantogranulomatosa: un reto actual para la laparoscopia.

OBJECTIVE: To present the results of our case series on laparoscopic nephrectomy in xanthogranulomatous pyelonephritis (XGP). METHODS: A retrospective study was conducted that included 143 patients treated with laparoscopic nephrectomy for non-functioning kidney, of whom 15 had XGP, within the time frame of 2011 to 2019. The demographic and clinical data were collected, along with the intraoperative results, complications, and days of hospital stay. RESULTS: Transperitoneal laparoscopic nephrectomy was successfully performed on 15 patients with XGP, with no need for conversion. Mean intraoperative time was 124.4 minutes (range 70-240) and intraoperative blood loss was 148.5 ml (range 30-550), with no blood transfusion required. No intraoperative complications occurred but there was one postoperative complication (6.6%), classified as Clavien-Dindo I (surgical wound infection). Mean hospital stay was 2.85 days (range 2-7). CONCLUSIONS: Nephrectomy is the definitive management for XGP, and the laparoscopic approach should be considered a treatment modality, despite the fact that the pathology involves a severe chronic inflammatory process. Its benefits are reduced surgery duration, less blood loss, a lower complication rate, and fewer days of hospital stay, when performed by a skilled and experienced surgeon.

OBJETIVO: Presentar los resultados de nuestra serie de nefrectomía laparoscópica en pielonefritis xantogranulomatosa (PXG). MÉTODO: Se realizó un estudio retrospectivo que incluyó 143 pacientes tratados con nefrectomía laparoscópica por exclusión renal, de los cuales 15 fueron por PXG, en el periodo comprendido de 2011 a 2019. Se recolectaron datos demográficos y clínicos, resultados transoperatorios, complicaciones y días de estancia hospitalaria. RESULTADOS: Se realizó nefrectomía laparoscópica transperitoneal de forma exitosa en 15 pacientes con PXG, sin necesidad de conversión. El tiempo transoperatorio promedio fue de 124.4 minutos (rango: 70-240). El sangrado transoperatorio fue de 148.5 ml (rango: 30-550), sin requerimiento de transfusión sanguínea. No se reportaron complicaciones transoperatorias; se presentó una complicación en el posoperatorio (6.6%) clasificada como Clavien-Dindo I (infección de la herida quirúrgica). La estancia hospitalaria promedio fue de 2.85 días (rango: 2-7). CONCLUSIONES: El manejo definitivo de la PXG es la nefrectomía, y el abordaje laparoscópico debe ser considerado como una modalidad de tratamiento a pesar de ser una patología que presenta un proceso inflamatorio grave y crónico, obteniéndose beneficios como disminución en el tiempo quirúrgico, menor sangrado, menor tasa de complicaciones y menos días de estancia hospitalaria cuando es realizado por un cirujano experimentado.

Antibodies to Aedes aegypti D7L salivary proteins as a new serological tool to estimate human exposure to Aedes mosquitoes.

Introduction: Aedes spp. are the most prolific mosquito vectors in the world. Found on every continent, they can effectively transmit various arboviruses, including the dengue virus which continues to cause outbreaks worldwide and is spreading into previously non-endemic areas. The lack of widely available dengue vaccines accentuates the importance of targeted vector control strategies to reduce the dengue burden. High-throughput sensitive tools to estimate human-mosquito contact and evaluate vector control interventions are lacking. We propose a novel serological tool that allows rapid screening of large human cohorts for exposure to potentially infectious mosquitoes and effective targeting of vector control. Methods: We tested 563 serum samples from a longitudinal pediatric cohort study previously conducted in Cambodia. Children enrolled in the study were dengue-naïve at baseline and were followed biannually for dengue incidence for two years. We used Western blotting and enzyme-linked immunosorbent assays to identify the most immunogenic Aedes aegypti salivary proteins and measure total anti- Ae. Aegypti IgG. Results: We found a strong correlation (r s =0.86) between the combined IgG responses against AeD7L1 and AeD7L2 recombinant proteins and those to whole salivary gland homogenate. We observed seasonal fluctuations of AeD7L1+2 IgG responses, corresponding to Aedes spp. abundance in the region, and no cross-reactivity with Culex quinquefasciatus and Anopheles dirus mosquitoes. The baseline median AeD7L1+2 IgG responses for young children were higher in those who developed asymptomatic dengue versus those who developed symptomatic dengue. Conclusion: The IgG response against AeD7L1+2 recombinant proteins is a highly sensitive and Aedes specific marker of human exposure to Aedes bites that can facilitate standardization of future serosurveys and epidemiological studies by its ability to provide a robust estimation of human-mosquito contact in a high-throughput fashion.

Orthopedic correction of growing hyperdivergent, retrognathic patients with miniscrew implants.

Traditional orthodontic treatments do not adequately address the skeletal problems of retrognathic, hyperdivergent, Class II adolescents; the few approaches that do address them require long-term patient compliance. This article introduces a novel approach using miniscrew implants (MSIs) and growth to treat retrognathic, hyperdivergent adolescents. Nine consecutive patients were evaluated at the start of treatment (aged 13.2 ± 1.1 years) and again at the end of the orthopedic phase (after 1.9 ± 0.3 years). Each patient had 2 MSIs placed in either side of the palate. Coil springs (150 g) extended from the MSIs to a rapid palatal expander, which served as a rigid segment for intruding the maxillary premolar and molars. Two additional MSIs were placed between the first mandibular molars and second premolars; coil spring (150 g) extended from the MSIs to hold or intrude the mandibular molars. Before treatment, the patients exhibited substantial and significant mandibular retrusion (Z score = -1.0), facial convexity (Z score = 0.7), and hyperdivergence (Z score = 1.6). Treatment produced consistent and substantial orthopedic effects. The chin was advanced by a mean of 2.4 mm, the sella-nasion-basion (SNB) angle increased by 2.1°, the mandibular plane angle decreased by 3.9°, and facial convexity decreased by approximately 3.2°. Questionnaires showed that this treatment approach was not painful or uncomfortable; the majority of the patients indicated that they were very likely to recommend the treatment to others. Treatment was accomplished by titrating the amount of orthodontic intrusion performed based on the individual's growth potential.

Histologic evaluation of root response to intrusion in mandibular teeth in beagle dogs.

INTRODUCTION: The purpose of this article was to histologically evaluate root resorption and repair after orthodontic intrusion with different force magnitudes and fixed anchorage. METHODS: A randomized split-mouth repeated-measure design was used. Intrusive forces were applied for 98 days to the mandibular second, third, and fourth premolars of 8 mature beagle dogs. Two miniscrew implants were used as anchorage to apply constant intrusive forces of 50, 100, or 200 g per tooth. Demineralized sections of each tooth were stained and histologically studied for root resorption. Multilevel statistical procedures were used to evaluate the results. RESULTS: Root resorption was present in all teeth, independent of the force applied. Significant differences were found between root regions, with the apices and the interradicular regions the most affected and with dentin involvement at the furcation. There was cementum repair in 24.14% of the lacunae. Light constant intrusive forces between 50 and 200 g showed no significant differences in the amount of resorption produced. Resorption was more frequently seen at the level of the apices and the furcation. CONCLUSIONS: Orthodontically induced root resorption is not clinically significant after application of continuous intrusive forces between 50 and 200 g. Moreover, there is no relationship between root resorption, the position of posterior mandibular teeth in the arch, and the amount of intrusive force applied.

Pupillary Responses for Cognitive Load Measurement to Classify Difficulty Levels in an Educational Video Game: Empirical Study.

BACKGROUND: A learning task recurrently perceived as easy (or hard) may cause poor learning results. Gamer data such as errors, attempts, or time to finish a challenge are widely used to estimate the perceived difficulty level. In other contexts, pupillometry is widely used to measure cognitive load (mental effort); hence, this may describe the perceived task difficulty. OBJECTIVE: This study aims to assess the use of task-evoked pupillary responses to measure the cognitive load measure for describing the difficulty levels in a video game. In addition, it proposes an image filter to better estimate baseline pupil size and to reduce the screen luminescence effect. METHODS: We conducted an experiment that compares the baseline estimated from our filter against that estimated from common approaches. Then, a classifier with different pupil features was used to classify the difficulty of a data set containing information from students playing a video game for practicing math fractions. RESULTS: We observed that the proposed filter better estimates a baseline. Mauchly's test of sphericity indicated that the assumption of sphericity had been violated (χ214=0.05; P=.001); therefore, a Greenhouse-Geisser correction was used (ε=0.47). There was a significant difference in mean pupil diameter change (MPDC) estimated from different baseline images with the scramble filter (F5,78=30.965; P<.001). Moreover, according to the Wilcoxon signed rank test, pupillary response features that better describe the difficulty level were MPDC (z=-2.15; P=.03) and peak dilation (z=-3.58; P<.001). A random forest classifier for easy and hard levels of difficulty showed an accuracy of 75% when the gamer data were used, but the accuracy increased to 87.5% when pupillary measurements were included. CONCLUSIONS: The screen luminescence effect on pupil size is reduced with a scrambled filter on the background video game image. Finally, pupillary response data can improve classifier accuracy for the perceived difficulty of levels in educational video games.

Accuracy and reliability of tooth and root lengths measured on cone-beam computed tomographs.

INTRODUCTION: In this study, we evaluated the accuracy and reliability of tooth-length and root-length measurements derived from cone-beam computed tomography (CBCT) volumetric data. METHODS: CBCT scans were made of 7 fresh porcine heads. The scans were made with an i-CAT machine (Imaging Sciences International, Hatfield, Pa) at 0.2, 0.3, and 0.4 mm voxel sizes. Two film-acquired periapical radiographs were also taken of selected incisors and premolars, 52 of which (28 premolars, 24 incisors) were included in this study. By using Dolphin imaging software (version 10.5, Dolphin Imaging Systems, Chatsworth, Calif), the CBCT scans were oriented twice for each tooth (ie, 2 trials) using the mesial, distal, labial, and lingual cementoenamel junctions as reference points. Root and tooth lengths were derived from these points and compared with actual measurements of the teeth made with digital calipers after all surrounding bone had been carefully removed. RESULTS: CBCT tooth-length and root-length measurements were not significantly different from the actual lengths; the mean differences were less than 0.3 mm. The periapical measurements significantly (P = 0.001) underestimated root lengths (mean difference, 2.58 mm) and overestimated tooth lengths (mean difference, 2.58 mm; P = 0.056). Mean differences between the 3 CBCT voxel sizes were all less than 0.25 mm. Within-trial method errors were almost 2 times greater for the periapical radiographs than for the CBCT scans. Between-trial method errors were greatest for the 0.4-mm CBCT scans, which were within 0.1 mm of the periapical radiograph method errors. The intraclass correlations for the periapical and CBCT measurements were all above 0.995. CONCLUSIONS: CBCT scans are at least as accurate and reliable as periapical radiographs for tooth-length and root-length determinations.

Orthodontic treatment for a patient with congenital cutis laxa.

This case report was shown at the student case display, sponsored by the College of Diplomates of the American Board of Orthodontics at the 2006 AAO Annual Session.

Effects of intentional damage of the roots and surrounding structures with miniscrew implants.

INTRODUCTION: The purposes of the study were to evaluate the immediate damage to roots and periodontal structures after initial miniscrew implant (MSI) placement and the short- and long-term damage after MSIs were left in situ. METHODS: The roots of the maxillary second, third, and fourth premolars of 7 mature beagle dogs were randomly assigned to undergo immediate, short-term (left for 6 weeks), or long-term (left for 12 weeks) damage. Intentional damage was inflicted with self-tapping screws (1.8 x 8 mm) placed with a stent. Alternating tetracycline and calcein labels were administered at 6-week intervals. Undecalcified sections were stained and evaluated histologically to determine the extent of damage; healing was evaluated by using fluorescence labels. RESULTS: Histology showed damage to 73.8% of the teeth, ranging from displacement of bone into the periodontal ligament to invasion of the pulp chamber. Displacement of bone into the periodontal ligament and direct damage to the periodontal ligament occurred in 3 (7.2%) instances. Damage was isolated to the cementum of 8 (19.0%) teeth, whereas damage occurred in the dentin of 11 (26.2%) teeth. Loss of bone in the furcation was evident in 3 (7.2%) teeth, and severe damage into the pulp occurred in 6 (14.2%) teeth. No differences in the amounts of damage were evident between the immediate, short-, and long-term groups. Healing often occurred with cementum around the unloaded MSIs. CONCLUSIONS: Extensive damage can be caused by MSIs, with little to no differences evident over time. Unloaded MSIs that remain in contact with roots of teeth can show varying degrees of healing.

Healing of the roots and surrounding structures after intentional damage with miniscrew implants.

INTRODUCTION: In this study, we evaluated the healing potential of the roots and surrounding periodontium (cementum, periodontal ligament [PDL], and bone) after intentional damage during miniscrew implant (MSI) placement. METHODS: A randomized split-mouth design was used to evaluate healing 6 and 12 weeks after intentional root damage. Seven skeletally mature male beagle dogs had MSIs placed into the roots of 8 mandibular teeth (6 premolars, 2 first molars). After root contact had been verified by using insertion torques and radiographs, the MSIs were immediately removed, and the sites were allowed to heal for 6 or 12 weeks. Sequential point labeling was performed at 6-week intervals with tetracycline and calcein. Demineralized and undemineralized sections were stained, and healing was histologically evaluated. RESULTS: The placement torque was twice as high with root contact than without contact (23.8 vs 50.7 Ncm). Damage to the roots and periodontium ranged from cementum interruption to pulp invasion. New bone, PDL, and cementum were observed in 64.3% of the teeth, with significant (P <0.05) increases in the percentages of cementum over time. Sequential labeling confirmed healing at both 6 and 12 weeks. Abnormal healing was found in 35.7% of teeth; it included lack of PDL and bone regeneration, bone degeneration in the furcation area, ankylosis, and no healing associated with inflammatory infiltrate or pulpal invasion. CONCLUSIONS: Under favorable conditions (no inflammatory infiltrate or pulpal invasion), healing can occur when root damage caused by MSIs is limited to the cementum or the dentin. Increased resistance should be used as an indicator of possible root contact during MSI placement.

Do orthopedic corrections of growing retrognathic hyperdivergent patients produce stable results?

OBJECTIVES: To determine if posterior dental intrusion produces stable orthodontic and orthopedic corrections in growing retrognathic hyperdivergent patients. MATERIALS AND METHODS: The sample included 14 subjects (five males and nine females), who were 13.4 ± 0.7 years pretreatment, treated for 3.5 years, and followed for 3.6 years posttreatment. During the initial orthopedic phase, 150 g NiTi coil springs were attached to two palatal miniscrew implants (MSIs) for maxillary intrusion; two buccal mandibular MSIs were used for posterior vertical control. Full orthodontic therapy was initiated to correct the malocclusions during the orthodontic phase. Patients were recalled a minimum of 1 year posttreatment (mean 3.6 ±1.6 years). Patients were compared to matched untreated controls. RESULTS: Relative to the untreated controls, during treatment and retention, maxillary and mandibular molars underwent 2.8 mm and 3.7 mm of relative posterior intrusion, respectively. Maxillary incisors were extruded 1.3 mm and the mandibular incisors underwent 2.9 mm of relative intrusion. Overall orthopedic changes included a reduction in the mandibular plane angle (MPA; 3.3°), an increase in SN-Pg (2.4°), an increase in S-N-B (2.1°), and a 4.3 mm relative reduction in anterior facial height. The maxillary incisors, which showed 0.6 mm of intrusion (relative to controls), was the only dental or skeletal measure to show a statistically significant between-group posttreatment difference. CONCLUSIONS: Except for maxillary incisor position, the substantial dental intrusion and associated orthopedic corrections that were produced during treatment remained stable post-treatment.

Maxillary and mandibular dentoalveolar heights of French-Canadians 10 to 15 years of age.

OBJECTIVE: To establish reference data for anterior and posterior dentoalveolar heights of growing French-Canadians with untreated normal occlusions and malocclusions. MATERIALS AND METHODS: The mixed longitudinal sample includes 227 French-Canadians, 119 male and 108 female, with cephalograms taken annually between 10-15 years of age. Maxillary and mandibular dentoalveolar heights were measured as the perpendicular distances of the incisor tips and first molar mesial cusp tips to the palatal (ANS-PNS) and mandibular (Go-Me) planes. RESULTS: Male dentoalveolar heights were significantly (P < .05) greater than female heights at all ages. Dentoalveolar heights at 15 years of age were significantly larger (P < .05) than at 10 years of age, with differences ranging from 2.1-4.2 mm in male subjects and from 2.1-3.8 mm in female subjects. The greatest difference in dentoalveolar heights between the 10- and 15-year-old age groups was for the maxillary first molar; the maxillary central incisor height showed the smallest age effects. The coefficients of variation were greater for the maxillary than the mandibular dentoalveolar heights. Correlations of dentoalveolar heights within jaws ranged from 0.53 to 0.82; correlations between jaws ranged from 0.30 to 0.44. The mandibular heights showed the strongest associations. CONCLUSIONS: French-Canadian adolescents require age- and sex-specific reference data for dentoalveolar heights.

Functional response of the predatory mite Chileseius camposi (Acarina: Phytoseiidae) on densities of it prey, Panonychus ulmi (Acarina: Tetranychidae).

The functional response of the phytoseiid predator Chileseius camposi González y Schuster, 1962 (Acarina:Phytoseiidae) on densities of its prey Panonychus ulmi (Koch, 1836) was evaluated under controlled temperature (20 +/- 2 degrees C), relative humidity (75 +/- 15%) and photoperiod (16:8h L:D). A functional type II response was displayed (Holling's disk). Holling, Wolf transformation and Rogers models gave similar values for estimating parameters of the Holling's disk equation; however, estimates produced by the Livdahl and Stiven model were higher. Values of attack rate and handling time can be considered within the normal range for phytoseiid generalists.

Segmental intrusion with mini-screw implant anchorage: a radiographic evaluation.

INTRODUCTION: The orthodontist's ability to intrude and control supraeruption of multiple teeth is fundamental for effective and efficient treatment outcomes. To better understand segmental intrusion with fixed anchorage, we evaluated the effects of various forces on the amount of intrusion, root resorption, and mini-screw implant (MSI) stability. METHODS: The sample included 8 mature beagle dogs, 20 to 24 months old. Intrusive forces were applied for 98 days by using a cast Vitallium appliance (Vitallium; Dentsply, York, Pa) incorporating the maxillary first, second, and third premolars as segments on each side. To accurately control the forces applied, 2 MSIs, 1 anterior and 1 posterior, were placed at the level of the first and third premolars of each segment. The sample was randomly divided into 2 groups; group 1 (n = 4) was assigned to have constant intrusive forces of 50 g anteriorly and 100 g posteriorly; the forces for group 2 (n = 4) were opposite those of group 1. Standardized periapical radiographs were taken at 14-day intervals to evaluate segmental intrusion and root resorption. Multilevel statistical procedures were used to model the treatment changes. RESULTS: All MSIs remained stable throughout the experiment. Small but significant (P <.05) amounts of root resorption (0.6 mm or less) occurred at the apices. Statistically significant (P <.05) amounts of intrusion were obtained for the segments of group 1 (2.0 mm anterior, 1.5 mm posterior). Only the anterior aspect of the segment of group 2 was intruded significantly (0.9 mm). CONCLUSIONS: Segmental intrusion can be achieved successfully and reliably with immediately loaded MSIs and relatively light forces (150 g). Force distribution plays an important role in determining how the segments were intruded.

Intrusion of multiradicular teeth and related root resorption with mini-screw implant anchorage: a radiographic evaluation.

INTRODUCTION: Mini-screw implants (MSIs) hold great potential for enhancing intrusive mechanics applied to multiradicular teeth. This experimental study used various force magnitudes to evaluate (1) the stability of immediately loaded MSIs, (2) the amounts of tooth intrusion produced, and (3) the amounts of root resorption produced. METHODS: By using a split-mouth repeated-measures design, intrusive forces were applied for 98 days to the mandibular second (LPM2), third (LPM3), and fourth (LPM4) premolars of 8 mature beagle dogs (ages, 20-24 months). With 12 MSIs (IMTEC, Ardmore, Okla) placed in the lingual and buccal cortical plates of each dog, Sentalloy coil springs (GAC International, Bohemia, NY) applied constant intrusive forces of 50, 100, or 200 g per tooth. The intrusive forces were randomly assigned between pairs of teeth; LPM2 was loaded with 50 or 100 g, LPM3 with 100 or 200 g, and LPM4 with 50 or 200 g. Multilevel statistical procedures were used to model tooth movements and root resorption, based on 64 standardized radiographs per tooth taken at 14-day intervals. RESULTS: Only 1 of the 96 immediately loaded MSIs failed. Significant (P <.05) amounts of intrusion, from 1.2 to 3.3 mm, were obtained after 98 days of force application. The statistical models showed no significant differences in the amounts of tooth movement between pairs of teeth loaded with different force magnitudes. Root resorption at the furcation and apices was 0.1 mm or less. CONCLUSIONS: Constant intrusive forces from 50 to 200 g produce clinically significant amounts of intrusion with little or no root resorption, suggesting that immediately loaded MSIs hold great promise as fixed anchorage devices for intruding multiradicular teeth.