Detalhe da pesquisa
1.
Once-daily oral small-molecule glucagon-like peptide-1 receptor agonist lotiglipron (PF-07081532) for type 2 diabetes and obesity: Two randomized, placebo-controlled, multiple-ascending-dose Phase 1 studies.
Diabetes Obes Metab
; 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38751362
2.
Pharmacological Inhibition of CETP (Cholesteryl Ester Transfer Protein) Increases HDL (High-Density Lipoprotein) That Contains ApoC3 and Other HDL Subspecies Associated With Higher Risk of Coronary Heart Disease.
Arterioscler Thromb Vasc Biol
; 42(2): 227-237, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34937388
3.
Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging.
Diabetologia
; 61(12): 2598-2607, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29721633
4.
Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects.
Br J Clin Pharmacol
; 83(2): 326-338, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27621150
5.
The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID.
Am J Med
; 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38735354
6.
Early markers of choroidal neovascularization in the fellow eye of patients with unilateral exudative age-related macular degeneration.
Ophthalmologica
; 225(3): 144-9, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21071996
7.
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
Nat Med
; 27(10): 1836-1848, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34635855
8.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver-Targeting Acetyl-CoA Carboxylase Inhibitor (PF-05221304): A Three-Part Randomized Phase 1 Study.
Clin Pharmacol Drug Dev
; 9(4): 514-526, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32065514
9.
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems.
Cell Mol Gastroenterol Hepatol
; 10(4): 829-851, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32526482
10.
De novo lipogenesis is essential for platelet production in humans.
Nat Metab
; 2(10): 1163-1178, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32929234
11.
Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis.
Sci Transl Med
; 11(520)2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31776293
12.
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Sci Transl Med
; 11(492)2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31092695
13.
Differential loss of presynaptic dopaminergic markers in Parkinsonian monkeys.
Cell Transplant
; 16(3): 229-44, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17503735
14.
Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.
J Med Chem
; 57(24): 10512-26, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25423286
15.
Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin.
Metabolism
; 61(10): 1486-93, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22560055
16.
High throughput object-based image analysis of ß-amyloid plaques in human and transgenic mouse brain.
J Neurosci Methods
; 204(1): 179-188, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22019329
17.
In vivo MRI assessment of knee cartilage in the medial meniscal tear model of osteoarthritis in rats.
Med Image Comput Comput Assist Interv
; 13(Pt 3): 57-64, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20879383
18.
Effects of lasofoxifene on the pharmacokinetics and pharmacodynamics of single-dose warfarin.
Br J Clin Pharmacol
; 61(6): 741-5, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16722839