Effectiveness and safety of pembrolizumab monotherapy in patients with locally advanced or metastatic non-small-cell lung cancer.

INTRODUCTION: Immunotherapy has become a standard treatment for lung cancer; the objective of this study was to evaluate the effectiveness, safety of pembrolizumab monotherapy in patients with advanced or metastatic non-small-cell lung cancer used in real-world clinical practice. MATERIAL AND METHODS: Retrospective observational study of every patient treated with pembrolizumab in our centre from January 2017 to June 2019. Outcomes collected: sex, age, Eastern Cooperative Oncology Group, programmed death receptor 1 level, previous metastatic line therapies, adverse events and smoking status. RESULTS: A total of 62 patients were reviewed. The median age was 62.34 ± 10.62 years, 48 (77.41%) were men and 91.93% of patients had Eastern Cooperative Oncology Group 0. The median dose administered was 170.5 mg (108 - 240 mg) and the median follow-up was 3 months (range: 1 - 38). A median of four cycles of pembrolizumab (range: 1 - 56) were administered as monotherapy. The reason for treatment discontinuation was mainly due to disease progression in 38.70% of patients or death in 30.64%. As first-line pembrolizumab monotherapy, median progression-free survival was 7.7 months (95% CI: 3.66 - 11.73) (N = 33). With respect to patients who were treated in second-third-line treatment, median progression-free survival was 3.5 months (95% CI: 2.40 - 4.59) (N=29). As to overall survival, pembrolizumab-treated patients as first-line treatment reached 19 months median OG (95% CI: 13.36 - 24.63) (N = 33) and those treated in second-third-line treatment got 11 months (95% CI: 3.4 - 18.5). A total of 64.51% of patients presented some adverse events to pembrolizumab however, only, 9.38% of them were grade 3. CONCLUSION: Pembrolizumab represents an effective and feasible alternative in terms of progression-free survival. It is a well-tolerated treatment option.

Understanding the antecedents of healthy and unhealthy weight control behaviours: Grit, motivation and self-control.

OBJECTIVE: To understand the psychological antecedents or personal factors that lead to weight control behaviours that can help to develop more effective prevention strategies. DESIGN: The present correlational study has a non-experimental, quantitative, cross-sectional design. A model was tested considering types of motivation (autonomous motivation, controlled motivation and amotivation) as mediators in the relationship between the Grit personality and healthy and unhealthy weight control behaviours, with self-control as a moderator in the aforementioned indirect effects. SETTING: Monterrey (Nuevo León, México). PARTICIPANTS: A representative sample of 1219 adults (men = 599; women = 620) aged 18-65 years (M = 29·37, sd = 11·83). RESULTS: Findings supported the mediator role of the types of motivation. Specifically, Grit showed a positive indirect effect on healthy weight control behaviours through autonomous motivation. Conversely, Grit showed a negative indirect effect on unhealthy weight control behaviours through autonomous motivation. Furthermore, findings supported the moderator role of self-control in the relationship between amotivation and healthy and unhealthy weight control behaviours. CONCLUSIONS: This study provides evidence for the key role of Grit in the adoption of healthy or unhealthy control behaviours, as well as the role of autonomous motivation in the development of healthy behaviours.

Perceived movement skill competence in stability: Validity and reliability of a pictorial scale in early adolescents.

Perceived motor competence (PMC) is important to health as it mediates the association between actual motor competence (AMC) and physical activity. Many instruments assess the broader construct of physical self-perception but no scale has been developed to assess PMC in stability. The aim of this study was to develop and analyze the reliability and validity of a new pictorial PMC in stability skill assessment when completed by early adolescents. A Delphi method showed ≥70% of experts' consensus in the seven proposed items. A sample of 904 students (11-14 years old) self-reported PMC in locomotion, object control, and stability using two pictorial scales: Perceived Movement Skill Competence (PMSC) and the newly developed Stability (PMSC_Stability). The Körperkoordinations test for Kinder (KTK) was also administered as a measure of AMC in skills that utilize stability. Two different subsamples were randomly assigned to criterion validity and reliability assessments. Spearman's correlation, confirmatory factor analysis, and a general linear model for sex and age were conducted. The internal consistency (α) and test-retest (intraclass correlation coefficient) reliability values were good (>0.70). A single-factor latent model represented stability and did not differ by sex. Stability perception was associated with AMC (rho = 0.51). Stability is important to the performance of many movement skills (eg, single-leg balance or moving on a narrow surface). Understanding which adolescents have poor stability perception could highlight stability as an area that needs targeting in order to increase physical activity and sport participation.

On-POM Ring-Opening Polymerisation of N-Carboxyanhydrides.

The ring-opening polymerisation of α-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted and narrow molecular weight distributions. Here we show how polyoxometalates (POMs)-redox-active molecular metal-oxide anions-can serve as inorganic scaffold initiators for such NCA polymerisations. This "On-POM polymerisation" strategy serves as an innovative platform to design hybrid materials with additive or synergistic properties stemming from the inorganic and polypeptide component parts. We have used this synthetic approach to synthesise a library of bactericidal poly(lysine)-POM hybrid derivatives that can be used to prevent biofilm formation. This versatile "On-POM polymerisation" method provides a flexible synthetic approach for combining inorganic scaffolds with amino acids, and the potential to tailor and improve the specificity and performance of hybrid antimicrobial materials.

Non-coding RNAs and Ischemic Cardiovascular Diseases.

The Ischemic Heart Disease (IHD) is considered a clinical condition characterized by myocardial ischemia causing an imbalance between myocardial blood supply and demand, leading to morbidity and mortality across the worldwide. Prompt diagnostic and prognostic represents key factors for the treatment and reduction of the mortality rate. Therefore, one of the newest frontiers in cardiovascular research is related to non-coding RNAs (ncRNAs), which prompted a huge interest in exploring ncRNAs candidates for utilization as potential therapeutic targets for diagnostic and prognostic and/or biomarkers in IHD. However, there are undoubtedly many more functional ncRNAs yet to be discovered and characterized. Here we will discuss our current knowledge and we will provide insight on the roles and effects elicited by some ncRNAs related to IHD.

Initial psychometric testing of the coach-adapted version of the empowering and disempowering motivational climate questionnaire: A Bayesian approach.

The present study examined the psychometric properties of the coach-adapted version of the Empowering and Disempowering Motivational Climate Questionnaire (EDMCQ) using Bayesian structural equation modelling (BSEM). The sample included 780 (Mage = 36.4; SD = 10.8; males n = 698; females n = 54; 28 participants did not report sex) youth sport coaches representing five European countries (i.e., England, France, Greece, Norway, and Spain). The results did not support a 34-item five-factor, hierarchical, a two-factor BSEM, or a bifactor BSEM model across the participating countries. However, the results supported a reduced 19-item first-order, two-factor BSEM model that largely showed approximate metric invariance, but not approximate scalar invariance across the five countries. The pool of items constituting empowering and disempowering motivational climates should be refined to further enhance the empirical operationalisation of the coach-adapted version of the EDMCQ. Advancing the quality of translation-back-translation procedures across cultures and conducting multi-national pilot testing seems warranted as well. These recommendations may help to identify the distinctive aspects of each underlying sub-dimension of the EDMCQ, where coaches are the respondents, and pave the way for further examination of the proposed hierarchical multidimensional factor structure and the cross-cultural equivalence of the EDMCQ for this population.

Antifungal Activity of Polyoxometalate-Ionic Liquids on Historical Brick.

Moulds inhabiting mineral-based materials may cause their biodeterioration, contributing to inestimable losses, especially in the case of cultural heritage objects and architectures. Fungi in mouldy buildings may also pose a threat to human health and constitute the main etiological factor in building related illnesses. In this context, research into novel compounds with antifungal activity is of high importance. The aim of this study was to evaluate the antifungal activity of polyoxometalate-ionic liquids (POM-ILs) and their use in the eradication of moulds from historical brick. In the disc diffusion assay, all the tested POM-ILs inhibited growth of a mixed culture of moulds including Engyodontium album, Cladosporium cladosporioides, Alternaria alternata and Aspergillus fumigatus. These were isolated from the surfaces of historical brick barracks at the Auschwitz II-Birkenau State Museum in Oswiecim, Poland. POM-IL coatings on historical brick samples, under model conditions, showed that two compounds demonstrated very high antifungal activity, completely limiting mould growth and development. The antifungal activity of the POM-ILs appeared to stem from their toxic effects on conidia, as evidenced by environmental scanning transmission electron microscopy observations. The results herein indicated that POM-ILs are promising disinfectant materials for use not only on historical objects, but probably also on other mineral-based materials.

[From surveillance to action: Modifying therapeutic behaviours in gonococcal infections]. / De la vigilancia a la acción: modificando conductas terapéuticas en la infección gonocócica.

OBJECTIVES: To evaluate improvements in the prescriptions for gonococcal infection after developing a specific public health intervention. Furthermore, to ascertain the proportion of cases diagnosed by culture and current antimicrobial resistance. LOCATION: Galicia, Spain. DESIGN: Before-after study of adherence to the recommended treatment for gonococcal infection (ceftriaxone + azithromycin) after a Public Health intervention. PARTICIPANTS: All Primary Care physicians who had identified and treated a case of gonococcal infection. STUDY PERIOD: Preintervention (2012-13) and postintervention (2014-17). INTERVENTIONS: Access to the recommended treatment (ceftriaxone and azithromycin) was provided in Primary Care and all the information was disseminated to Primary Care physicians and microbiologists through the publication Venres Epidemiolóxico. MAIN MEASUREMENTS: The study variables were year, prescribed treatment, performing of culture, antibiotic susceptibility testing. The percentages for each of them were calculated. RESULTS: The recommended treatment was used in 3% in 2012-2013, and after the interventions it increased to a mean of 58%. The frequency of culture remained relatively constant after the interventions. Sensitivity to other antibiotics improved as their use decreased. CONCLUSIONS: The interventions carried out implied an improvement in the adherence to the recommended treatment for gonococcal infection in Galicia.

Water Purification and Microplastics Removal Using Magnetic Polyoxometalate-Supported Ionic Liquid Phases (magPOM-SILPs).

Filtration is an established water-purification technology. However, due to low flow rates, the filtration of large volumes of water is often not practical. Herein, we report an alternative purification approach in which a magnetic nanoparticle composite is used to remove organic, inorganic, microbial, and microplastics pollutants from water. The composite is based on a polyoxometalate ionic liquid (POM-IL) adsorbed onto magnetic microporous core-shell Fe2 O3 /SiO2 particles, giving a magnetic POM-supported ionic liquid phase (magPOM-SILP). Efficient, often quantitative removal of several typical surface water pollutants is reported together with facile removal of the particles using a permanent magnet. Tuning of the composite components could lead to new materials for centralized and decentralized water purification systems.

Polyoxometalate-Ionic Liquids (POM-ILs) as Anticorrosion and Antibacterial Coatings for Natural Stones.

Corrosion of stone by acid rain and deterioration from biofilms are global problems for industrial and residential buildings as well as cultural heritage, such as statues or historic buildings. Herein we show how typical building stones can be protected from corrosion ("weathering") and biofilm formation ("biodeterioration") by application of thin films of polyoxometalate-based ionic liquids (POM-ILs). Stone samples are coated with hydrophobic, acid resistant POM-ILs featuring biocidal properties. Exposure of the samples to simulated acid rain showed negligible corrosion compared to the significant deterioration of unprotected samples; in addition the biocidal properties of the POM-ILs suppress the formation of biofilms on coated stone slabs. A new class of modular molecular materials for protecting stones can now be developed for use in construction, environmental protection, and cultural heritage preservation.

Young Athletes' Perceptions of Coach Behaviors and Their Implications on Their Well- and Ill-Being Over Time.

Grounded on basic psychological needs theory the purpose of this study was twofold: (a) to test the mediational role of basic psychological needs (satisfaction and thwarting), and (b) to test the model invariance over 2 consecutive seasons. Three hundred sixty young male athletes completed a questionnaire package tapping the variables of interest at 4 time points during 2 consecutive seasons. Results of the path analyses revealed that in both seasons, changes in perceived coach autonomy supportive style positively predicted changes in needs satisfaction which, in turn, positively predicted changes in self-esteem; changes in perceived coach autonomy supportive and controlling style negatively and positively, respectively, predicted changes in needs thwarting which, in turn, positively predicted changes in burnout and negatively in self-esteem. Only in the first season, changes in needs satisfaction emerged as a negative predictor of changes in burnout. The mediational role of basic psychological needs and the invariance of the aforementioned relationships over the 2 seasons were supported. Results emphasize the importance of having coaches promoting autonomy supportive atmospheres and avoiding controlling styles to facilitate athletes' well-being and to prevent their ill-being.

Microsporidiosis acquired through solid organ transplantation: a public health investigation.

BACKGROUND: Encephalitozoon cuniculi, a microsporidial species most commonly recognized as a cause of renal, respiratory, and central nervous system infections in immunosuppressed patients, was identified as the cause of a temporally associated cluster of febrile illness among 3 solid organ transplant recipients from a common donor. OBJECTIVE: To confirm the source of the illness, assess donor and recipient risk factors, and provide therapy recommendations for ill recipients. DESIGN: Public health investigation. SETTING: Two transplant hospitals and community interview with the deceased donor's family. PATIENTS: Three transplant recipients and the organ donor. MEASUREMENTS: Specimens were tested for microsporidia by using culture, immunofluorescent antibody, polymerase chain reaction,immunohistochemistry, and electron microscopy. Donor medical records were reviewed and a questionnaire was developed to assess for microsporidial infection. RESULTS: Kidneys and lungs were procured from the deceased donor and transplanted to 3 recipients who became ill with fever 7 to 10 weeks after the transplant. Results of urine culture, serologic,and polymerase chain reaction testing were positive for E. cuniculi of genotype III in each recipient; the organism was also identified in biopsy or autopsy specimens in all recipients. The donor had positive serologic test results for E. cuniculi. Surviving recipients received albendazole. Donor assessment did not identify factors for suspected E. cuniculi infection. LIMITATION: Inability to detect organism by culture or polymerase chain reaction in donor due to lack of autopsy specimens. CONCLUSION: Microsporidiosis is now recognized as an emerging transplant-associated disease and should be considered in febrile transplant recipients when tests for routinely encountered agents are unrevealing. Donor-derived disease is critical to assess when multiple recipients from a common donor are ill.

Bicycling to university: evaluation of a bicycle-sharing program in Spain.

This study examined the change in behavioral stages (e.g. contemplation, action and maintenance) of cycling to university before and after the implementation of a new public bicycle share program (PBSP) and promotion of its use. The study also determined the change in the prevalence, correlates of PBSP use and potential role in the promotion of healthy weight. An 8-month follow-up cross-sectional study (September 2010-April 2011) was carried out among undergraduate students during the first season of implementation of the PBSP in Valencia, Spain. The sample was 173 students (68.2% female) with a mean age of 21.3 years (SD 3.06) who attended a PBSP promotional session. The data were collected by questionnaire. Results indicated a significant increase of 14.6% in the action/maintenance stage of change and showed that 19% of the participants were PBSP users 8 months later. The behavioral stage did not change when students always had access to car/motorbike, lived further than 5 km from the university and had no bicycle stations within 250 m from home. Those most likely to start using PBSP were students who were in the contemplation stage, perceived fewer environmental and safety barriers to active commuting and had one or more stations within 250 m of home. PBSP users expended ∼257 metabolic equivalent·minutes/week bicycling to university, and there was a small reduction in BMI. Findings suggest that PBSPs can be considered as useful promoters of cycling behavior and may contribute to weight control in university students.

[Streptococcus pneumoniae: serotype distribution, antimicrobial susceptibility, risk factors and mortality in Galicia over a two year-period]. / Streptococcus pneumoniae: distribución de serotipos, sensibilidad antibiótica, factores de riesgo y mortalidad en Galicia en un periodo de 2 años.

INTRODUCTION: To examine the epidemiology of pneumococcal infection in Galicia (Spain) after the incorporation of the pneumococcal conjugate vaccine, and to determine serotype distribution, antibiotic susceptibility, risk factors and associated mortality in cases of invasive pneumococcal disease (IPD) during 2011 and 2012. METHODS: All strains causing IPD in Galicia were studied. Serotyping was performed by agglutination and Quellung reaction. Antibiotic sensitivity to penicillin, cefotaxime, erythromycin, vancomycin, and levofloxacin was determined. The risk factors considered were chronic respiratory disease, heart disease, liver disease, kidney disease, diabetes mellitus, and HIV and non-HIV immunodeficiency. RESULTS: A total of 555 strains were collected, with 43 different serotypes being found. The most frequently isolated ones were: serotype3 (17.5%), serotype7F (12.6%), serotype19A (9.4%), serotype14 (4.1%), serotype6C (4.1%), serotype11A (4%) and serotype22F (3.8%). 57.1% of isolates were serotypes included in VNC-13V. Two non-penicillin-sensitive strains and two others were not sensitive to cefotaxime, and 24.7% of the strains were not susceptible to erythromycin (26.9% in 2011 and 22.5% in 2012). The case fatality rate was 16.5%, reaching 23.3% in patients over 75years. Diseases with a statistically significant risk of mortality were: liver, kidney and immunodeficiency without HIV. CONCLUSIONS: Serotype3 was the most frequent in Galicia. Very few strains were not susceptible to penicillin. Erythromycin resistance decreased from 2011 to 2012. It is highlighted that mortality increases with age. Liver disease, renal disease and non-HIV immunodeficiency increases the mortality risk.

Athlete's Personal Values and the Likelihood of Alcohol Use and Heavy Drinking during Adolescence.

Sport is considered an exceptional activity for promoting healthy lifestyles, but the relationship between sport and alcohol consumption is inconclusive. Research on personal values may shed light on this issue and thus make it possible to find effective ways to prevent alcohol misuse in adolescents. The main objectives of this study were to explore the relationships between personal values and alcohol consumption amongst adolescent athletes and to validate the Portrait Values Questionnaire-21 (PVQ-21) in this population. A total of 914 athletes (aged 11-19; 55.4% female) participated in this study. Confirmatory multidimensional scaling analysis and confirmatory factor analysis were performed. Logistic regression models were fitted to assess the predictive power of personal values on alcohol use. Openness to change values positively predicted high-frequency alcohol use and high-frequency heavy episodic drinking, whereas the opposite occured with athletes who held conservation values. Furthermore, the probability of presenting heavy episodic drinking was negatively associated with conservation values. Finally, the PVQ-21 presented adequate psychometric properties to assess personal values among adolescent athletes. It is crucial to consider the personal values of adolescent athletes when promoting healthy lifestyles through sport.

Time perspectives and procrastination in university students: exploring the moderating role of basic psychological need satisfaction.

BACKGROUND: Research on procrastination, regarding time perspective factors and basic psychological need satisfaction (BPNS) has placed this problem at the meeting point of individual and contextual variables. The present study focused both on the individual, given that time perspectives can be defined as a person's attitude to an object (time) at three moments (present, past, future); and on contextual aspects, because the satisfaction of basic psychological needs (competence, autonomy, relatedness) is facilitated or made difficult by social contexts. Based on this, the aim of this study was to analyse the relationships between time perspectives and inter-subject procrastination variations, testing the moderating role of BPNS in this relationship. METHOD: A total of 1,188 undergraduate students, aged 17-50 years (M = 20.02, SD = 2.63), completed three questionnaires containing the variables of interest. RESULTS: Regression analyses showed significant negative (thus, potentially protective) association of future time perspective with all three procrastination dimensions (decisional procrastination, implemental delay, and lateness). Conversely, past-negative time perspective showed a positive (thus, potentially adverse) association with procrastination. Satisfaction of the need for competence also showed a negative (thus, potentially protective) association with all procrastination dimensions. On eight occasions, the relationships between time perspectives and procrastination dimensions were moderated by psychological need satisfaction. CONCLUSIONS: These findings show that BPNS may play relevant roles in the negative (favourable) relationships between procrastination dimensions and positive time perspectives, as well as in the positive (adverse) associations between negative time perspectives and procrastination dimensions. Contextual interventions fostering enhanced levels of perceived autonomy, competence, and relatedness, as well as future time perspective, are thus strong candidates to consider for use and evaluation by policy makers, pedagogues, teachers, coaches and other professionals interested in counteracting procrastination tendencies.

Interest and Perseverance Are Not Enough to Be Physically Active: The Importance of Self-Efficacy toward Healthy Eating and Healthy Weight to Move More in Adolescents.

(1) Background: Insufficient physical activity in adolescents remains an important issue for health promotion. Given the current relevance of understanding the adoption and maintenance of moderate and vigorous physical activity (MVPA), the aim of this study was to analyze, in a sample of adolescents, the role of grit personality as an antecedent of healthy eating and healthy weight (HEW) self-efficacy and its implications for the practice of MVPA. (2) Methods: Participants were 987 adolescents (597 girls, 390 boys) aged between 15 and 19 years from Mexico and Spain. The Spanish versions of the grit personality scale, the healthy eating and weight self-efficacy scale and the global physical activity questionnaire were used to measure the variables of interest. (3) Results: Mediated regression analysis showed that grit personality was not directly related to MVPA practice. However, the results indicate the significant relationship between grit personality and HEW self-efficacy, as well as the positive and significant relationship of this self-efficacy on MVPA practice. HEW self-efficacy totally mediated the relationship between grit personality and MVPA in both boys and girls. (4) Conclusions: These results suggest that having a grit personality (i.e., having interest and perseverance) is not enough for adolescents to be physically active, but that perceiving oneself as effective in having a healthy diet and healthy weight may be the key for adolescents to move more. At the intervention level, we suggest targeting an enhancement of young people's competence to eat healthily and regulate their weight as a strategy to enhance the performance of more MVPA, with a possible transfer between healthy behaviors (spill over).

Engagement in Youth Athletes as a Positive Experience in Sport: Implications of Gender, Age, and Competitive Level.

The aim of this study was to examine athlete engagement and its relationships with indicators of the quality of the athlete's sport experience, exploring potential differences according to gender, age, and competitive level. Furthermore, this study validated the Athlete Engagement Questionnaire (AEQ) in young athletes and confirmed its factor structure. A total of 1188 athletes (43.90% girls) from Argentina participated in the study, with a mean age of 15.92 (SD = 2.50). The participants completed the AEQ along with other measures of athletes' quality of experience, such as motivation, enjoyment, and burnout. This study confirmed the multidimensional nature of engagement, showing positive associations with high-quality athlete experiences and revalidating the inverse relationship with burnout. Moreover, the study found differences in engagement dimensions (i.e., confidence, vigor, dedication, and enthusiasm) based on the interplay of gender, age, and competitive level. In general, male athletes, younger athletes, and those with a higher competitive level showed more engagement and interactions between these sociodemographic variables. The Argentinian version of AEQ exhibited optimal fit and reliability and good indexes of measurement invariance across gender, age, and competitive level. These findings validate the AEQ as a reliable tool for evaluating sport engagement among adolescents in Argentina. Engagement constitutes an indicator of an optimal experience linked to positive youth development through sports participation.

Temporal progression of the distribution of Streptococcus pneumoniae serotypes causing invasive pneumococcal disease in Galicia (Spain) and its relationship with resistance to antibiotics (period 2011-2021).

INTRODUCTION: Streptococcus pneumoniae causes serious diseases in the susceptible population. The 13-valent pneumococci conjugate vaccine (PCV13) was included in the children's calendar in 2011. The objective of the study was to analyze the evolution of pneumococcal serotypes and their resistance after PCV13. METHODS: This study included the pneumococci serotyped in Galicia in 2011-2021. Antibiotic susceptibility was analyzed following EUCAST criteria. The data was analyzed in 3 sub-periods: initial (2011-2013), middle (2014-2017) and final (2018-2021). The prevalence of serotypes and their percentage of resistance to the most representative antibiotics were calculated. RESULTS: A total of 2.869 isolates were included. Initially, 42.7% isolates presented capsular types included in PCV13, compared to 15.4% at the end. Those included in PCV20 and not in PCV13 and PCV15 were 12.5% at baseline and 41.3% at the end; 26.4% of the isolates throughout the study had serotypes not included in any vaccine. The prevalence of serotype 8 multiplied almost by 8 and that of 12F tripled. The 19A serotype was initially the most resistant, while the resistance of serotypes 11A and 15A increased throughout the study. CONCLUSIONS: The introduction of PCV13 in the pediatric population determined a change in pneumococcal serotypes towards those included in PCV20 and those not included in any vaccine. Serotype 19A was initially the most resistant and the 15A, not included in any vaccine, deserves special follow-up. Serotype 8, which increased the most, did not show remarkable resistance.