Detalhe da pesquisa
1.
Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids.
PLoS Pathog
; 19(8): e1011559, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37619220
2.
Altered serine metabolism promotes drug tolerance in Mycobacterium abscessus via a WhiB7-mediated adaptive stress response.
Antimicrob Agents Chemother
; : e0145623, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38651855
3.
Mycobacteria-host interactions in human bronchiolar airway organoids.
Mol Microbiol
; 117(3): 682-692, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34605588
4.
Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis.
BMC Biol
; 20(1): 147, 2022 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35729566
5.
The final assembly of trehalose polyphleates takes place within the outer layer of the mycobacterial cell envelope.
J Biol Chem
; 295(32): 11184-11194, 2020 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32554804
6.
ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis.
Cell Microbiol
; 19(7)2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28095608
7.
Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli.
PLoS Pathog
; 9(7): e1003437, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23853582
8.
4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo.
PLoS Pathog
; 8(12): e1003097, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23308068
9.
Detection of soluble co-factor dependent protein expression in vivo: application to the 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis.
J Struct Biol
; 183(3): 320-328, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23916562
10.
Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.
J Biol Chem
; 287(40): 33675-90, 2012 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22825853
11.
In vivo imaging of MmpL transporters reveals distinct subcellular locations for export of mycolic acids and non-essential trehalose polyphleates in the mycobacterial outer membrane.
Sci Rep
; 13(1): 7045, 2023 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37120636
12.
Mycobacterium trehalose polyphleates are required for infection by therapeutically useful mycobacteriophages BPs and Muddy.
bioRxiv
; 2023 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993724
13.
Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleates.
Nat Microbiol
; 8(9): 1717-1731, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37644325
14.
Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.
PLoS Pathog
; 5(2): e1000289, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19197369
15.
Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds.
Sci Rep
; 11(1): 18042, 2021 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34508141
16.
Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors.
Front Cell Infect Microbiol
; 10: 420, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32923411
17.
Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases.
ACS Chem Biol
; 15(12): 3206-3216, 2020 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33237724
18.
Conformational flexibility of coenzyme A and its impact on the post-translational modification of acyl carrier proteins by 4'-phosphopantetheinyl transferases.
FEBS J
; 287(21): 4729-4746, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32128972
19.
Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis.
FEBS J
; 274(8): 1957-69, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17371506
20.
MmpL transporter-mediated export of cell-wall associated lipids and siderophores in mycobacteria.
Tuberculosis (Edinb)
; 100: 32-45, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27553408