RESUMO
Carney complex (CNC) is an extremely rare, autosomal dominant genetic syndrome consisting of pigmented skin and mucosal changes with multiple endocrine and nonendocrine tumors, including the breast. Breast tumors are typically multiple and benign and are most commonly reported as myxoid fibroadenomas and/or intraductal papillomas. We present a young female patient with known CNC who presented with copious bloody nipple discharge with multiple breast lumps and discuss the breast imaging features regarding this complex and often underrecognized genetic condition.
Assuntos
Neoplasias da Mama , Complexo de Carney , Fibroadenoma , Derrame Papilar , Papiloma Intraductal , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/patologia , Complexo de Carney/diagnóstico , Complexo de Carney/genética , Complexo de Carney/patologia , Feminino , Fibroadenoma/patologia , Humanos , Mamilos/patologia , Papiloma Intraductal/patologiaRESUMO
Patients undergoing total knee arthroplasty (TKA) are likely to receive a blood transfusion, which may increase the risk of complications and prolong hospital stay. Considerable variation exists in transfusion practice among orthopedic surgeons following elective TKA. Previous studies have investigated the relationship between preoperative risk factors and the requirement for blood transfusions in patients undergoing a total hip or knee arthroplasty, but few have focused on transfusion risk in those specifically undergoing TKA.The authors performed a retrospective review of a prospectively collected database of 2281 patients undergoing unilateral TKA in a district general hospital over a 10-year period. Multiple regression analysis models were used to identify risk factors associated with postoperative blood transfusion. A predictive model was created based on the regression coefficients and factor levels. The risk of transfusion was independently predicted by the patients' age at surgery (P<.001), preoperative hemoglobin (P<.001), weight (P=.009) and lateral retinacular release (P<.001). The preoperative variables of age, hemoglobin, and weight were incorporated into a model to provide an estimation of the transfusion risk. The area under the receiver operating characteristic curve was 74% (95% confidence interval, 70%-77.5%). This study identifies risk factors independently associated with the risk of requiring a blood transfusion following TKA. The predictive model stratifies the risk according to the individual patient in the preoperative setting, allowing preventative measures to take place preoperatively. It also helps in the counseling of patients at high risk of requiring a postoperative blood transfusion.