Detalhe da pesquisa
1.
Rational Design and Lead Optimisation of Potent Antimalarial Quinazolinediones and Their Cytotoxicity against MCF-7.
Molecules
; 28(7)2023 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37049762
2.
Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives.
J Nat Prod
; 84(4): 1261-1270, 2021 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33844528
3.
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping.
Philos Trans A Math Phys Eng Sci
; 377(2147): 20180422, 2019 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31030650
4.
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.
Proc Natl Acad Sci U S A
; 113(8): 2080-5, 2016 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26858419
5.
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Angew Chem Int Ed Engl
; 55(22): 6401-5, 2016 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27089538
6.
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.
Proc Natl Acad Sci U S A
; 109(21): 8298-303, 2012 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22566611
7.
Kaemtakols A-D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis.
Nat Prod Bioprospect
; 13(1): 55, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38036688
8.
ECDD-S16 targets vacuolar ATPase: A potential inhibitor compound for pyroptosis-induced inflammation.
PLoS One
; 18(11): e0292340, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38011122
9.
Receptor binding protein of prophage reversibly recognizes the low-molecular weight subunit of the surface-layer protein SlpA in Clostridioides difficile.
Front Microbiol
; 13: 998215, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36312948
10.
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
ACS Infect Dis
; 8(2): 296-309, 2022 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35037462
11.
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).
Eur J Med Chem
; 230: 114105, 2022 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35065413
12.
Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Angew Chem Int Ed Engl
; 55(36): 10548, 2016 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27552550
13.
Frontiers in antibiotic alternatives for Clostridioides difficile infection.
World J Gastroenterol
; 27(42): 7210-7232, 2021 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34876784
14.
High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents.
Sci Rep
; 10(1): 19963, 2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33203926
15.
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
Nat Commun
; 10(1): 11, 2019 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30602718
16.
A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.
Angew Chem Weinheim Bergstr Ger
; 128(22): 6511-6515, 2016 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27397940
17.
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
J Med Chem
; 55(5): 1831-43, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22364416
18.
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
J Med Chem
; 55(5): 1844-57, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22364417