Detalhe da pesquisa
1.
Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein.
Immunity
; 53(5): 1095-1107.e3, 2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33128877
2.
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.
Nature
; 547(7664): 453-457, 2017 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28678785
3.
MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Proc Natl Acad Sci U S A
; 116(15): 7533-7542, 2019 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30898885
4.
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.
Nat Chem Biol
; 9(12): 840-848, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24161946
5.
Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications.
Mol Cancer Ther
; 6(2): 404-17, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17308042
6.
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Mol Cancer Ther
; 5(2): 438-49, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16505119
7.
The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity.
Mol Cancer Ther
; 5(10): 2549-55, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17041099
8.
Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.
Clin Cancer Res
; 11(3): 1294-301, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15709201
9.
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
Cancer Res
; 64(9): 3313-9, 2004 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15126375
10.
A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed.
Cancer Res
; 62(22): 6434-7, 2002 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12438230
11.
Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers.
Mol Cancer Ther
; 4(12): 1860-6, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16373701
12.
Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.
Mol Neuropsychiatry
; 2(2): 97-106, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27606323
13.
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in ß-Cell Protection.
ACS Chem Biol
; 11(2): 363-74, 2016 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26640968
14.
Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier.
Clin Cancer Res
; 10(24): 8735-42, 2004 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15623659
15.
Lack of impact of the loss of constitutive folate receptor alpha expression, achieved by RNA Interference, on the activity of the new generation antifolate pemetrexed in HeLa cells.
Clin Cancer Res
; 10(23): 7986-93, 2004 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15585634
16.
HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of ß-catenin in human iPSC-derived neuronal cells.
ACS Chem Biol
; 10(3): 883-90, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25546293
17.
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
Cell Rep
; 10(5): 755-770, 2015 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25660025
18.
BCL2 blockade overcomes MCL1 resistance in multiple myeloma.
Leukemia
; 33(8): 2098-2102, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30816329
19.
The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs.
Curr Opin Investig Drugs
; 11(12): 1409-23, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21154123
20.
Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability.
Oncologist
; 12(7): 808-15, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17673612