Detalhe da pesquisa
1.
OTTM: an automated classification tool for translational drug discovery from omics data.
Brief Bioinform
; 24(5)2023 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37594310
2.
Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways.
FASEB J
; 37(4): e22893, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36961387
3.
High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases.
Nucleic Acids Res
; 50(2): e9, 2022 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34718755
4.
Structural Mass Spectrometry Probes the Inhibitor-Induced Allosteric Activation of CDK12/CDK13-Cyclin K Dissociation.
J Am Chem Soc
; 145(21): 11477-11481, 2023 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37207290
5.
Multi-instance learning of graph neural networks for aqueous pKa prediction.
Bioinformatics
; 38(3): 792-798, 2022 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34643666
6.
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors.
Bioorg Med Chem Lett
; 95: 129435, 2023 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37549850
7.
Loops Mediate Agonist-Induced Activation of the Stimulator of Interferon Genes Protein.
J Chem Inf Model
; 63(23): 7373-7381, 2023 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37831484
8.
Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase.
Bioorg Med Chem
; 91: 117413, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37490786
9.
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.
Acta Pharmacol Sin
; 44(4): 791-800, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36229599
10.
DrugSpaceX: a large screenable and synthetically tractable database extending drug space.
Nucleic Acids Res
; 49(D1): D1170-D1178, 2021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33104791
11.
Comprehensive quality evaluation of processed Scrophulariae Radix from different regions of China using HPLC coupled with chemometrics methods.
Phytochem Anal
; 34(7): 816-829, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36704818
12.
Drug repurposing against breast cancer by integrating drug-exposure expression profiles and drug-drug links based on graph neural network.
Bioinformatics
; 37(18): 2930-2937, 2021 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33739367
13.
Design, synthesis and biological evaluation of 2-aminopyridine derivatives as USP7 inhibitors.
Bioorg Chem
; 129: 106128, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36113266
14.
Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold.
Bioorg Chem
; 123: 105768, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35378372
15.
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib.
Acta Pharmacol Sin
; 43(2): 457-469, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33850273
16.
Natural product 1,2,3,4,6-penta-O-galloyl-ß-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase.
Acta Pharmacol Sin
; 43(2): 470-482, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33850276
17.
Lignans and Phenylethanoid Glycosides from the Aerial Parts of Pogostemon cablin.
Chem Biodivers
; 19(12): e202200889, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36349735
18.
(-)-α-Bisabolol Alleviates Atopic Dermatitis by Inhibiting MAPK and NF-κB Signaling in Mast Cell.
Molecules
; 27(13)2022 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35807237
19.
Effect of Different Processing Methods on the Chemical Constituents of Scrophulariae Radix as Revealed by 2D NMR-Based Metabolomics.
Molecules
; 27(15)2022 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35897871
20.
Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine.
Molecules
; 27(16)2022 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36014414