Detalhe da pesquisa
1.
Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity.
Bioorg Med Chem Lett
; 26(13): 3158-3162, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27180013
2.
Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics.
Bioorg Med Chem
; 22(1): 447-58, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24275348
3.
Discovery of an irreversible HCV NS5B polymerase inhibitor.
Bioorg Med Chem Lett
; 23(24): 6585-7, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24252545
4.
Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.
Bioorg Med Chem
; 21(7): 2007-17, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434368
5.
Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
Genome Biol
; 24(1): 41, 2023 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36869380
6.
Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor.
Cancer Res Commun
; 3(9): 1731-1742, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37663435
7.
Differential susceptibility to axonopathy in necrotic and non-necrotic perinatal white matter injury.
Stroke
; 43(1): 178-84, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22076007
8.
II. Novel HCV NS5B polymerase inhibitors: discovery of indole C2 acyl sulfonamides.
Bioorg Med Chem Lett
; 22(1): 713-7, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22104146
9.
I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles.
Bioorg Med Chem Lett
; 21(18): 5336-41, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21840715
10.
P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.
Bioorg Med Chem Lett
; 20(2): 567-70, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004570
11.
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bioorg Med Chem Lett
; 20(8): 2617-21, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303756
12.
Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection.
Acc Chem Res
; 41(1): 50-9, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18193821
13.
Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings.
Bioorg Med Chem Lett
; 19(4): 1105-9, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19168351
14.
Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue.
Bioorg Med Chem
; 16(4): 1874-83, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032054
15.
GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J Med Chem
; 60(22): 9162-9183, 2017 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28892380
16.
Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.
J Med Chem
; 49(2): 567-74, 2006 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16420042
17.
Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.
J Med Chem
; 49(3): 995-1005, 2006 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16451065
18.
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
J Med Chem
; 59(23): 10549-10563, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27682507
19.
Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.
J Med Chem
; 48(20): 6229-35, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190750
20.
The Journey to the Discovery of Boceprevir: an NS3-NS4 HCV protease inhibitor for the treatment of chronic hepatitis C.
Prog Med Chem
; 49: 1-36, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855037