Detalhe da pesquisa
1.
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates.
J Am Chem Soc
; 146(15): 10537-10549, 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38567991
2.
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.
Molecules
; 27(4)2022 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35209093
3.
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
J Biol Chem
; 294(27): 10392-10406, 2019 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31142553
4.
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity.
Proc Natl Acad Sci U S A
; 114(6): E1009-E1017, 2017 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28096355
5.
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
Proc Natl Acad Sci U S A
; 112(16): E1994-2003, 2015 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25855634
6.
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.
Biochemistry
; 56(9): 1177-1180, 2017 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28230968
7.
Correction: Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
J Biol Chem
; 295(4): 1142, 2020 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980482
8.
Amyloid-ß and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing.
J Am Chem Soc
; 138(12): 3966-9, 2016 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26967463
9.
Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies.
MAbs
; 15(1): 2231129, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37403264
10.
Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in a non-affinity cation exchange capture step.
PLoS One
; 18(1): e0280760, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36696419
11.
Excellent removal of knob-into-hole bispecific antibody byproducts and impurities in a single-capture chromatography.
Bioresour Bioprocess
; 9(1): 72, 2022 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38647639
12.
Effective flow-through polishing strategies for knob-into-hole bispecific antibodies.
Bioresour Bioprocess
; 9(1): 98, 2022 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38647877
13.
Current trends and challenges in the downstream purification of bispecific antibodies.
Antib Ther
; 4(2): 73-88, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-34056544
14.
Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy.
Life (Basel)
; 11(5)2021 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34064766
15.
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells.
Nat Commun
; 12(1): 1814, 2021 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753734
16.
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease.
Front Cell Dev Biol
; 9: 552549, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33829010
17.
Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies.
MAbs
; 12(1): 1718440, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31983280
18.
The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel ß-sheet α-synuclein aggregates.
Chem Sci
; 11(43): 11902-11914, 2020 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33520152
19.
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
Commun Biol
; 3(1): 435, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32792544
20.
The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure.
ACS Chem Biol
; 14(7): 1593-1600, 2019 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31074957