Magnetic-field-assisted optical fiber quantum temperature sensor with enhanced sensitivity.

In recent years, utilizing nitrogen-vacancy color centers in diamond for temperature sensing has drawn great attention. However, increasing the sensitivity has encountered challenges due to the intrinsic temperature-dependent energy level shift, i.e., temperature responsivity, being limited to -74 kHz/K. In this Letter, we take advantage of the magnetic field to regulate the energy level to enhance temperature sensitivity. The sensor is formed by adhering a micron-sized diamond on the end face of an optical fiber, and a small magnet is mounted at a certain distance with the diamond exploiting a cured polydimethylsiloxane block as the bridge. The temperature change leads to the variation of the distance between the diamond and the magnet, thus affecting the magnetic strength felt by the diamond. This finally contributes an additional temperature-induced energy level shift, giving rise to an enhanced sensitivity. Experimental results demonstrated the proposed scheme and achieved a 4.2-fold improvement in the temperature responsivity and a 2.1-fold enhancement in sensitivity. Moreover, the diamond and the fiber-optic integrated structure improve the portability of the sensor.

High-sensitivity optical-fiber magnetic sensor based on diamond and magnetic flux concentrators.

Magnetic field detection exploiting nitrogen-vacancy (NV) centers in diamond has gained increasing attention and development in recent years. Combining diamond NV centers to optical fibers provides a way for achieving magnetic sensors with high integration and portability. Meanwhile, new methods or techniques are urgently desired to improve the detection sensitivity of such sensors. In this paper, we present an optical-fiber magnetic sensor based on the NV ensemble in diamond, and employ the well-designed magnetic flux concentrators to enhance the sensitivity up to 12 pT/Hz1/2, an outstanding level among the diamond-integrated optical-fiber magnetic sensors. The dependence of sensitivity on the key parameters including the size and gap width of the concentrators are investigated by simulations and experiments, based on which the predictions on the further enhancement of sensitivity to fT level are presented.

Ultrahigh-sensitive and compact temperature sensor based on no-core fiber with PMMA coating.

A new mechanism between the temperature sensitivity and the length ratio of PMMA coating to no-core fiber (NCF) is reported to realize an optical fiber temperature sensor with ultra-high sensitivity and compact size by PMMA-coated no-core fiber. By both theory and experiment, it is found that the sensitivity has a linear response to the length ratio of PMMA coating to NCF rather than the conventional viewpoint that it depends on the length of PMMA. Based on this conclusion and the high thermo-optic coefficient of PMMA, the temperature sensitivity is significantly enhanced as high as -9.582 nm/℃ through a simple, compact, and inexpensive sensor with 5 mm NCF and 3 mm PMMA coating. Our work opens a new avenue of a significant increase in the detection sensitivity of miniaturized fiber temperature sensors.

Exploiting black phosphorus based-Tamm plasmons in the terahertz region.

Polarization-sensitive Tamm plasmons are investigated in a multi-layer photonic configuration where a monolayer black phosphorus (BP) is coated on a Bragg mirror separated by a dielectric. Owing to the in-plane anisotropy of BP, the Tamm plasmon can be excited selectively by tuning the BP carrier density. Cross-polarization conversion occurs when the armchair direction of BP makes an angle with the incident plan, i.e., ϕ≠0 or 90°. The BP-based Tamm device can be used as an intensity modulator with a modulation depth up to ∼100% and an insertion loss smaller than -0.55 dB. By analyzing the polarization evolution carefully, a multichannel polarization division multiplexing scheme is proposed and discussed. These findings open a new avenue for exploiting versatile tunable THz devices based on the monolayer of BP.

High-performance fiber plasmonic sensor by engineering the dispersion of hyperbolic metamaterials composed of Ag/TiO2.

Hyperbolic metamaterials (HMMs) have attracted increasing attentions because of their unique dispersion properties and the flexibility to control the dispersion by changing the components and fractions of the composed materials. In this work, for the first time, we demonstrate a plasmonic sensor based on a side-polished few-mode-fiber coated with a layered of HMM, which is composed of alternating layers of Ag and TiO2. To optimize the sensor performance, the effects of the metal filling fraction (ρ) and the number of bilayers (Nbi) on the HMM dispersion are thoroughly engineered with the effective medium theory and the finite element method. It is found that the HMM with ρ=0.7 and Nbi = 3 can provide the average sensitivity of 5114.3 nm/RIU (RIU: refractive index unit), and the highest sensitivity 9000 nm/RIU in the surrounding refractive index (SRI) ranging from 1.33 to 1.40 RIU. The corresponding figure of merit (FOM) reaches a maximum of 230.8 RIU-1 which is much higher than that of the conventional silver film based SPR sensor. The influence of ρ and Nbi on the sensitivity are well explained from the aspects of the electrical field distribution and the dispersion relationship. This work opens a gate to significantly improve fiber plasmonic sensors performance by engineering the HMM dispersion, which is expected to meet the emergent demand in the biological, medical and clinical applications.

Half-side gold-coated hetero-core fiber for highly sensitive measurement of a vector magnetic field.

A highly sensitive surface plasmon resonance fiber sensor for a vector magnetic field is proposed. The sensor is composed of a half-side gold-coated multimode-single-mode-multimode hetero-core fiber structure encapsulated with ferrofluids. The half-side gold film on the fiber not only produces the surface plasmon resonance, but also breaks the centrosymmetry of the light field in the fiber. Moreover, the magnetic-field-dependent anisotropy of the surrounding ferrofluids makes the sensor sensitive to both the intensity and direction of the magnetic field. Owing to the unique half-side coating configuration and the resulting enhancement of the evanescent field, the sensor can achieve a sensitivity as high as 1008 pm/Oe to the magnetic field intensity. The proposed sensor, possessing advantages such as high sensitivity, ease of fabrication, and low cost, has potential in the detection of a weak vector magnetic field.

A portable optical fiber SPR temperature sensor based on a smart-phone.

In this paper, a fiber-optic temperature sensing system, based on surface plasmon resonance (SPR) and integrated with a smart-phone platform, is proposed and demonstrated. The sensing system is composed of a side-polished-fiber-based SPR sensor, which is illuminated by the LED flash from one end, and the output signals are recorded and processed by the camera and a designed application in the smart-phone. The sensing performance is evaluated by immersing the sensor in distilled water under different temperatures. Experimental results show that the measurement resolution of the proposed temperature sensor can reach 0.83°C in the range from 30 to 70°C, corresponding to a linear correlation coefficient of 0.9798. The low-cost and portable fiber optic SPR sensor based on a smart-phone platform has wide application potentials in the fields of health-care, environmental monitoring, etc.

Side-polished few-mode fiber based surface plasmon resonance biosensor.

The fiber geometry, fiber parameters and mode-guiding properties are crucial for realizing high-performance fiber-based sensors. In this work, we propose and demonstrate a few-mode fiber (FMF)-based surface plasmon resonance (SPR) biosensor. The FMF-SPR sensor was fabricated via side-polishing a few-mode fiber and coating a thin layer of gold film, on the basis of the optimization of fiber geometry, thickness of the gold film and mode selection, which were performed with the finite element method. The refractive index (RI) sensing performance of three such sensors with different residual fiber thicknesses were investigated. In the RI range from 1.333 to 1.404, the highest sensitivity up to 4903 nm/RIU and a figure of merit of 46.1 RIU-1 are achieved. For testing the bovine serum albumin (BSA) solution, an averaged BSA RI sensitivity of 6328 nm/RIU and an averaged BSA concentration sensitivity of 1.17 nm/(mg/ml) are realized. Benefiting from only a few modes supported in the FMF, a smaller line-width of the SPR spectrum is obtained, which further results in a higher figure of merit (FOM). Moreover, when combined with the superiority of the mode-multiplexing technology brought by the FMF, the FMF-SPR sensors may find applications in biochemical analysis with high performance and high throughputs.

Tunable asymmetric spin splitting by black phosphorus sandwiched epsilon-near-zero-metamaterial in the terahertz region.

In-plane photonic spin splitting effect is investigated in tunneling terahertz waves through an epsilon-near-zero metamaterial sandwiched between monolayer black phosphorus (BP). The strong in-plane anisotropy of BP layers will induce in-plane asymmetric spin splitting. The asymmetric spin splitting can be flexibly tuned by the angles between the incident plane and the armchair crystalline directions of the top and bottom BP layers, i.e., ϕ1 and ϕ2. Based on this, an angle-resolved barcode-encryption scheme is discussed. For the special case of ϕ1 = ϕ2 = 0 or 90°, the transmitted beam undergoes Goos-Hänchen shift, which varies with the carrier density of BP. We believe these findings can facilitate the development of novel optoelectronic devices in the Terahertz region.

Titanium dioxide nanoparticle modified plasmonic interface for enhanced refractometric and biomolecular sensing.

A surface plasmon resonance (SPR) biosensor, which contains an overlayer of titanium dioxide nanoparticles (TDNPs) to modify the plasmonic interface, has been developed and investigated. Owing to its large surface area and high refractive index, the TDNP overlayer significantly enhances the probing electric field intensity and detection sensitivity. This sensitivity is related to the TDNP overlayer thickness, which can be engineered by changing the TiO2-ethanol dispersion's spin-coating concentration. The highest refractive index sensitivity for ethylene glycol measurement is 2567.3 nm/RIU, which is 38% higher than that of a conventional SPR sensor with an uncoated gold film. The proposed TDNP-SPR sensor also exhibits a 1.59-fold sensitivity enhancement in fetal bovine serum detection. Moreover, the proposed interface modification approach that is applied without additional biochemical amplification steps is chemical-free and contamination-free; therefore this TDNP-SPR sensor could be integrated into a sensitive, cost-effective, and biocompatible platform for rapid and label-free biochemical detection.

Sensitivity-enhanced surface plasmon sensor modified with MoSe2 overlayer.

In this work, a sensitivity-enhanced surface plasmon resonance (SPR) sensor, which is integrated with MoSe2 as modification overlayer, is proposed and investigated. The sensor is constructed by physically depositing MoSe2 onto the surface of a conventional SPR sensor based on Krestchman configuration. Thanks to the commendable properties of MoSe2 including high carrier mobility, high refractive index (RI), large surface area, and so forth, adding an overlayer within a certain thickness can effectively improve the RI sensitivity. Experimental results show that, with the increased number of deposition cycles-which positively correlates with the duty ratio and the MoSe2 overlayer's thickness-the sensitivity at first increases, and then declines. The highest sensitivity of 2524.8 nm/RIU is achieved experimentally, which corresponds to the 2 deposition cycles. This shows an improvement of 36.3%, compared with the case without the MoSe2 modification. The ease of fabrication, efficiency of performance enhancement, and great potentials (such as the large surface area of MoSe2 for linking abundant functional groups) allow the method presented in this paper to contribute to the development of performance-enhanced SPR sensors for the biological, chemical, and medical fields.

High-sensitivity vector magnetic field sensor based on side-polished fiber plasmon and ferrofluid.

A high-sensitivity vector magnetic field is proposed and demonstrated. The sensor consists of a side-polished-fiber (SPF)-based surface plasmon resonance (SPR) structure integrated with ferrofluid. Because of the high refractive index sensitivity of the SPR scheme and the outstanding magneto optical properties of ferrofluid, the sensor shows a high sensitivity (up to 598.7 pm/Oe) to magnetic field intensity. Moreover, owing to the non-circular-symmetric geometry of the SPF and non-uniform distribution of the ferrofluid around the SPF, the sensor exhibits a sensitivity of -5.63 nm/deg to the orientation of the magnetic field. The proposed vector magnetic field sensor, integrating over magnetic, plasmonic, and fiber-optic schemes, is highly sensitive to both the intensity and orientation of the magnetic field simultaneously, and holds potential in applications in many fields, such as medicine, industry, and the military.

Numerical investigation of the thermal effect on Yb-cavity-copumped Er/Yb codoped fiber amplifiers.

Thermal effects are critical constraints for developing high-power Er/Yb-codoped fiber amplifiers (EYDFAs), especially those with an auxiliary Yb-band cavity. In this paper, we developed a numerical model to investigate the temperature-dependent effects on EYDFAs with an Yb-band cavity with consideration of thermal-induced cross-section changes. Our results show that the quantum-defect-induced heat affects the performance of the EYDFA, and its effect varies with the resonant wavelength of the Yb-band cavity. There is a finite applicable resonant wavelength range limited by thermal damage. So, it is important to take into account the thermal effect during the design of such EYDFAs in order to optimize their performance and determine the heat dissipation systems.

Sensor based on macrobent fiber Bragg grating structure for simultaneous measurement of refractive index and temperature.

A novel and compact all-fiber sensor based on a macrobent fiber Bragg grating (FBG) structure for simultaneous measurement of refractive index (RI) and temperature is proposed and experimentally investigated. The sensor can be easily fabricated by properly bending an FBG. The bending causes interference between the core mode and the whispering gallery mode, which induces another kind of dip in the transmission spectra of the sensor besides the sharp one of the FBG. Because the two kinds of dips respond differently to the surrounding RI and temperature, these two parameters can be unambiguously measured by the sensor. A sample sensor was fabricated and experimentally investigated, and RI sensitivity of 165.9276 nm/RIU in the range from 1.3330 to 1.3785 and temperature sensitivity of 31.7 pm/°C were achieved. This sensor provides a convenient and economical way for applications where temperature and RI have to be simultaneously measured.

Highly efficient Er/Yb-codoped fiber amplifier with an Yb-band fiber Bragg grating.

In this Letter, a high-power Er/Yb-codoped fiber amplifier (EYDFA) with a high-reflection Yb-band fiber Bragg grating (FBG) at the pump end is experimentally investigated. The FBG was inscribed on a piece of double-clad fiber with a center wavelength of 1032 nm. Due to the selective reflection of the backward Yb-band amplified spontaneous emission (Yb ASE) by the FBG, a co-pump-propagating Yb-band auxiliary signal was generated. Because of the stimulated amplification and reabsorption of the auxiliary signal, the Yb ASE was dramatically suppressed and the pump conversion efficiency (PCE) of the EYDFA was notably improved. An output power of 6.48 W was achieved at a pump power of 16.5 W, which is equivalent to a PCE of ∼39%. The slope efficiency relative to applied pump power was ∼40%. The maximum output power was improved ∼20% because of the introduction of the FBG.

Self-Assembled Monolayer and Nanoparticles Coenhanced Fragmented Silver Nanowire Network Memristor.

Silver nanowire (AgNW) networks with self-assembled structures and synaptic connectivity have been recently reported for constructing neuromorphic memristors. However, resistive switching at the cross-point junctions of the network is unstable due to locally enhanced Joule heating and the Gibbs-Thomson effect, which poses an obstacle to the integration of threshold switching and memory function in the same AgNW memristor. Here, fragmented AgNW networks combined with Ag nanoparticles (AgNPs) and mercapto self-assembled monolayers (SAMs) are devised to construct memristors with stable threshold switching and memory behavior. In the above design, the planar gaps between NW segments are for resistive switching, the AgNPs act as metal islands in the gaps to reduce threshold voltage (Vth) and holding voltage (Vhold), and the SAMs suppress surface atom diffusion to avoid Oswald ripening of the AgNPs, which improves switching stability. The fragmented NW-NP/SAM memristors not only circumvent the side effects of conventional NW-stacked junctions to provide durable threshold switching at >Vth but also exhibit synaptic characteristics such as long-term potentiation at ultralow voltage (≪Vth). The combination of NW segments, nanoparticles, and SAMs blazes a new trail for integrating artificial neurons and synapses in AgNW network memristors.

Optical fiber magnetic field sensor based on single-mode-multimode-single-mode structure and magnetic fluid.

An optical fiber magnetic field sensor based on the single-mode-multimode-single-mode (SMS) structure and magnetic fluid (MF) is proposed and demonstrated. By using a piece of no-core fiber as the multimode waveguide in the SMS structure and MF sealed in a capillary tube as the magnetic sensitive media, which totally immersing the no-core fiber, an all-fiber magnetic sensor was fabricated. Interrogation of the magnetic field strength can be achieved either by measuring the dip wavelength shift of the transmission spectrum or by detecting the transmission loss at a specific wavelength. A demonstration sensor with sensitivities up to 905 pm/mT and 0.748 dB/mT was fabricated and investigated. A theoretical model for the design of the proposed device was developed and numerical simulations were performed.

MALAT1 participates in the role of platelet-rich plasma exosomes in promoting wound healing of diabetic foot ulcer.

Exosomes isolated from platelet-rich plasma (PRP-exos) have been recently deemed as an optimized therapeutic strategy in diabetic foot ulcer (DFU) treatment. Herein, we aimed to explore whether MALAT1 participates in DFU wound healing by PRP-exos treatment and the related preliminary mechanism. Fibroblasts were isolated from healthy donors and DFU patients, and the expression of MALAT1, miR-374a-3p and DNMT3A were detected by RT-PCR. The effect of MALAT1 and miR-374a-3p on DFU fibroblast function was verified by gain/loss of function experiment. The targeted binding of MALAT and miRNA was verified by double luciferase reporter gene assay. PRP-exos were isolated from normal human blood and characterized, and then co-cultured with DFU fibroblasts. The MALAT1 expression was donwregulated while the miR-374a-5p expression was upregulated in DFU fibroblasts. Double luciferase reporter gene assay demonstrated the targeted binding of MALAT and miR-374a-5p. Overexpression of MALAT1 or knockdown of miR-374a-5p could increase viability and inhibit apoptosis and pyroptosis of DFU fibroblast. And overexpression of miR-374a-5p reversed the effect of PRR-exos or MALAT1 overexpression on cell viability, apoptosis and pyroptosis. Collectively, MALAT1 mediated signal axis participates in the role of PRP-exos in promoting DFU wound healing, which may help identify optimal targets and effective therapies for DFU treatment.

MoS2-Nanoflower and Nanodiamond Co-Engineered Surface Plasmon Resonance for Biosensing.

Surface plasmon resonance (SPR) based sensors play an important role in the biological and medical fields, and improving the sensitivity is a goal that has always been pursued. In this paper, a sensitivity enhancement scheme jointly employing MoS2 nanoflower (MNF) and nanodiamond (ND) to co-engineer the plasmonic surface was proposed and demonstrated. The scheme could be easily implemented via physically depositing MNF and ND overlayers on the gold surface of an SPR chip, and the overlayer could be flexibly adjusted by controlling the deposition times, thus approaching the optimal performance. The bulk RI sensitivity was enhanced from 9682 to 12,219 nm/RIU under the optimal condition that successively deposited MNF and ND 1 and 2 times. The proposed scheme was proved in an IgG immunoassay, where the sensitivity was twice enhanced compared to the traditional bare gold surface. Characterization and simulation results revealed that the improvement arose from the enhanced sensing field and increased antibody loading via the deposited MNF and ND overlayer. At the same time, the versatile surface property of NDs allowed a specifically-functionalized sensor using the standard method compatible with a gold surface. Besides, the application for pseudorabies virus detection in serum solution was also demonstrated.

Omentin-1 alleviate interleukin-1ß(IL-1ß)-induced nucleus pulposus cells senescence.

One of the main causes of low back pain (LBP) and degenerative musculoskeletal disorders is intervertebral disc degeneration (IVDD). Inflammation-associated senescence of Human nucleus pulposus cells (HNPCs) plays an essential function in the disease progression of IVDD. Omentin-1 is an adipokine that has been recently reported to have anti-inflammatory potential. In our research, IL-1ß was used to simulate the inflammatory environment in the IVDD. We investigated in vitro the effects of Omentin-1 on HNPCs, including the components of senescence, cell cycle and extracellular matrix (ECM) synthesis. The results showed that the addition of Omentin-1 improved IL-1ß-induced senescence in HNPCs. G1 phase cell cycle arrest and reduced ECM synthesis in HNPCs. Furthermore, we demonstrated that the effect of Omentin-1 in reducing senescence of HNPCs is dependent on SIRT1. These findings suggest that Omentin-1 plays an important function in protecting HNPCs against senescence and has the potential for IVDD gene target therapy.