Detalhe da pesquisa
1.
A model ß-sheet interaction and thermodynamic analysis of ß-strand mimetics.
Org Biomol Chem
; 13(27): 7402-7, 2015 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26088610
2.
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.
J Med Chem
; 66(15): 10617-10627, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37467168
3.
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
J Med Chem
; 66(8): 5907-5936, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017629
4.
Synthesis and in vivo evaluation of 3-substituted gababutins.
Bioorg Med Chem Lett
; 20(1): 362-5, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19897364
5.
Synthesis and in vivo evaluation of bicyclic gababutins.
Bioorg Med Chem Lett
; 20(2): 461-4, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20005103
6.
HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target.
Clin Cancer Res
; 24(10): 2395-2407, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29391353
7.
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).
J Med Chem
; 61(3): 918-933, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29240418
8.
Privileged Structures and Polypharmacology within and between Protein Families.
ACS Med Chem Lett
; 9(12): 1199-1204, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613326
9.
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
J Med Chem
; 60(1): 180-201, 2017 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28004573
10.
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.
Medchemcomm
; 7(8): 1580-1586, 2016 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27746890