1.
Angew Chem Int Ed Engl
; 62(36): e202307251, 2023 Sep 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37428447
RESUMO
A unique benzannulation strategy for regioselective de novo synthesis of densely functionalized phenols is described. Through metal-mediated formal [2+2+1+1] cycloaddition of two different alkynes and two molecules of CO, a series of densely functionalized phenols were obtained. The benzannulation strategy allows efficient regioselective installation up to five different substituents on a phenol ring. The resulting phenols have a substitution pattern different from those obtained from Dötz and Danheiser benzannulations.