RESUMO
OBJECTIVE: To evaluate the effectiveness of a knee adduction moment (KAM) gait retraining in patients with early knee osteoarthritis up to 6 months post-training. METHOD: We conducted a single blinded randomized controlled trial on a total of 23 patients with early knee osteoarthritis who were randomly allocated to the gait retraining group and walking exercise group. Twenty of them completed the corresponding training and the 6-month evaluation. We measured KAM, knee flexion moment (KFM) and western ontario and McMaster universities osteoarthritis index (WOMAC) osteoarthritis index before, immediate after, and 6 months after training. A repeated measures analysis of covariance (ANCOVA) was used to compare KAM, KFM and WOMAC osteoarthritis index scores across the three time points i.e., pre-training, post-training, and 6-month follow-up with gender, knee osteoarthritis severity, and pre-training KAM, KFM and WOMAC scores set as covariates. Post-hoc analyses were conducted when indicated. RESULTS: Significant time × group interactions were found for both KAM and WOMAC osteoarthritis index scores (P < 0.002). No interaction was found for KFM (P = 0.123). KAM after gait retraining was significantly lower than the pre-training value (P < 0.001) and such effect was maintained at 6-month follow-up (P = 0.01). There was no significant difference in the KAM across time in the walking exercise group (P > 0.208). WOMAC osteoarthritis index score after training and score at the 6-month follow-up were significantly improved in the gait retraining group (P = 0.001), while the WOMAC osteoarthritis index score remained similar. CONCLUSIONS: Gait retraining is an effective intervention to reduce KAM during walking and to improve the symptoms of patients with early knee osteoarthritis in short term.
Assuntos
Marcha/fisiologia , Articulação do Joelho/fisiopatologia , Osteoartrite do Joelho/fisiopatologia , Modalidades de Fisioterapia , Amplitude de Movimento Articular , Caminhada/fisiologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Joelho/terapia , Método Simples-Cego , Fatores de Tempo , Resultado do TratamentoRESUMO
BACKGROUND AND PURPOSE: Both blood pressure (BP) and its variability (BPV) are established risk factors for development of atherosclerotic disease and are associated with an increased risk for cardiovascular and all-cause mortality. The prognostic implications of outpatient clinic visit-to-visit BPV amongst patients with lacunar infarction are nevertheless unknown. METHODS: The clinical outcome of 281 patients with lacunar infarction was prospectively followed up. The average BP and BPV, as determined by the standard deviation of the systolic and diastolic BP, were recorded during a mean 13 ± 6 outpatient clinic visits. RESULTS: The mean age of the population was 70 ± 10 years. After a mean 78 ± 18 months follow-up, 65 patients died (23%), 31% (20/65) due to cardiovascular causes; 14% and 7% developed recurrent stroke and acute coronary syndrome. After adjusting for age, sex, mean systolic and diastolic BP, cardiovascular risk factors and comorbidities, patients with a systolic BPV of the third tertile had significantly higher risk of all-cause mortality [hazard ratio (HR) 1.97, 95% confidence interval (CI) 1.02-3.80, P = 0.04) and cardiovascular mortality (HR 7.64, 95% CI 1.65-35.41, P < 0.01) than those with systolic BPV of the first tertile. Nevertheless, systolic BPV did not predict recurrent stroke or acute coronary syndrome. Diastolic BPV did not predict various adverse clinical outcomes. CONCLUSIONS: Visit-to-visit systolic BPV predicts long-term all-cause and cardiovascular mortality after lacunar infarct, independent of conventional risk factors including average BP control.
Assuntos
Pressão Sanguínea/fisiologia , Doenças Cardiovasculares/mortalidade , Acidente Vascular Cerebral Lacunar/mortalidade , Idoso , Idoso de 80 Anos ou mais , Determinação da Pressão Arterial , Doenças Cardiovasculares/fisiopatologia , Causas de Morte , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Acidente Vascular Cerebral Lacunar/fisiopatologiaRESUMO
OBJECTIVE: Delay onset of the vastus medialis obliquus (VMO) has often been reported to happen in people with patellofemoral pain (PFP). Previous studies revealed that a motion control shoe could check rearfoot pronation in overpronators. Literature suggested that movements of the lower leg could affect patellar tracking; thus motion control shoe may help prevent PFP by controlling excessive foot movements. This study aimed to compare the vasti muscle activities in people with excessive foot pronation when running with different footwear. METHODS: Twenty female subjects with rearfoot pronation >6 degrees were tested by running for 10 km on a treadmill on two separate days. During each test, subjects either wore a motion-control running shoe or a neutral running shoe. EMG activities of their right VMO and vastus lateralis (VL) were recorded. Their EMG onset timing and median frequency (MF) were compared between the two shoe conditions. RESULTS: A more significant delay in VMO onset of the running duty cycle was observed in the neutral shoe condition than in the motion control shoe (p<0.001). In the neutral shoe condition, the delay in VMO increased with running mileage (Pearson correlation = 0.948), whereas no such pattern was observed in the motion control shoe. A significant drop in MF of the quadriceps after the 10 km run in both shoe conditions was observed (p ranged from <0.001 to 0.008), and there was a larger drop in VMO MF when running with the neutral shoe. CONCLUSIONS: The findings suggest that the motion control shoe may facilitate a stable temporal activation of VMO during running.
Assuntos
Pronação/fisiologia , Músculo Quadríceps/fisiologia , Corrida/fisiologia , Adulto , Eletromiografia , Desenho de Equipamento , Feminino , Humanos , Síndrome da Dor Patelofemoral/etiologiaRESUMO
OBJECTIVES: Mental health literacy is fundamental to the pursuit of health. Little is known about patients' literacy levels regarding depression even though it is common among elderly stroke survivors. This paper will report the level of mental health literacy and thematic constructs of depression interpreted by a group of stroke survivors. METHOD: Qualitative data on patients' understanding of 'depression' in Chinese were translated and analyzed by an academic and a researcher separately to identify emerging constructs using a thematic approach. Out of 214 ischemic stroke older adults, aged 50+, 85 were able to explain the term in their own words after their first stroke attack. RESULTS: The majority of stroke patients (60%, 129 out of 214) had never heard of depression and only four referred to it as a medical disease. Only a third would like to learn more about depression. Older Chinese adults depicted depression mainly by using words in the cognitive and affective domains, but the descriptors used were mostly non-specific and might not match the diagnostic criteria for depression or the commonly used screening tools. CONCLUSION: Low mental health literacy among older patients indicated that much more work needs to be done in health promotion and education on depression literacy.
Assuntos
Depressão/psicologia , Escolaridade , Conhecimentos, Atitudes e Prática em Saúde , Acidente Vascular Cerebral/psicologia , Idoso , Povo Asiático/psicologia , Depressão/etnologia , Depressão/reabilitação , Feminino , Humanos , Masculino , Saúde Mental , Pessoa de Meia-Idade , Fatores Socioeconômicos , Acidente Vascular Cerebral/etnologia , Reabilitação do Acidente Vascular Cerebral , Inquéritos e Questionários , SobreviventesRESUMO
UNLABELLED: In Hong Kong, there is a paucity of evidence to support which tool is superior in measuring depression after stroke (DAS). A simple, non-language-based, culturally neutral, non-verbal and easy to apply tool that is not highly dependent on training will be desirable. OBJECTIVES: The present study aimed to examine the clinical utility of three smiley pictures in detecting DAS for older Chinese patients at 1 month after first-ever ischemic stroke. METHODS: This was a cross-sectional study. A total of 253 stroke patients were interviewed by a research nurse at 1-month follow-up. RESULTS: Taking Diagnostic and Statistic Manual (DSM IV) as the gold standard, the measurement properties of emoticon (sad) in terms of sensitivity, specificity, positive and negative predictive values, as well as Kappa's value were found comparable to Geriatric Depression Scale (GDS). The emoticon (happy) demonstrated a highly significant inverse relationship with all depression assessment tools (p<0.001). It was also found that the emoticon (flat) could capture 98% of all depressed subjects identified by DSM IV, although its predictive values were less satisfactory. CONCLUSIONS: The smiley pictures seemed to fulfil the requirements for early and prompt screening among older patients. Cultural implication regarding emotions dissipation among Chinese patients should be further studied.
Assuntos
Depressão/diagnóstico , Acidente Vascular Cerebral/complicações , Idoso , Idoso de 80 Anos ou mais , China , Estudos Transversais , Depressão/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de RiscoRESUMO
BACKGROUND: Knee adduction moment (KAM) is often used as a surrogate marker of knee contact force (KCF) during walking. Previous studies have reported potential benefits to reduce KAM in patients with knee osteoarthritis (OA) by foot progression angle adjustment. However, KAM is an external moment and it does not consider any muscle contribution to the joint loading, which should pose a greater influence in running than walking. RESEARCH QUESTION: This study used a computational model to compare KAM and KCF between runners with and without knee OA during running. In addition, we evaluated the KAM and KCF when runners adjusted to an out-toe running style. METHODS: Kinematic, kinetic, and lower limb EMG data were collected from 9 runners with knee OA and 10 healthy counterparts. They were asked to run at their usual speed with standard shoes on an instrumented treadmill. RESULTS: We found no significant difference in the KAM during running between OA and the healthy group (pâ¯>â¯0.376). However, runners with knee OA exhibited a greater total KCF than the healthy counterparts (pâ¯<â¯0.041). We did not observe any reduction in KAM after foot progression angle adjustment (pâ¯>â¯0.346). Surprisingly, an increase in the longitudinal KCF and total KCF were found with adjustment of foot progression angle (pâ¯<â¯0.046). SIGNIFICANCE: Unlike the findings reported by the previous walking trials, our findings do not support the notion that foot progression angle adjustment would lead to a lower joint loading during running.
Assuntos
Pé/fisiopatologia , Articulação do Joelho/fisiopatologia , Osteoartrite do Joelho/fisiopatologia , Corrida/fisiologia , Suporte de Carga/fisiologia , Adulto , Idoso , Análise de Variância , Fenômenos Biomecânicos , Estudos de Casos e Controles , Progressão da Doença , Eletromiografia , Feminino , Pé/fisiologia , Marcha/fisiologia , Humanos , Articulação do Joelho/fisiologia , Masculino , Pessoa de Meia-IdadeRESUMO
OBJECTIVE: Acquired myasthenia gravis (MG) is predominantly due to nicotinic acetylcholine receptor (AChR) autoantibodies (Ab). Differences between nonthymoma early-onset and late-onset MG were reported. We studied the clinical and serological characteristics of nonthymoma AChR Ab-positive-generalized MG patients. PATIENTS AND METHODS: Chinese AChR Ab-positive-generalized MG patients who had generalized disease for 3 years or longer were studied. RESULTS: Among 41 such patients, 25 (61%) were female. The mean onset age was 43.5 years (range 9-78 years) and the mean follow-up duration was 7.8 years (range 3-20 years). Sixteen (39%) patients had late-onset disease (onset age >or=50 years). Compared to early-onset patients (onset age <50 years), late-onset patients were characterized by male predominance (p=0.002), absence of thymic lymphofollicular hyperplasia (p=0.036), and a higher striated muscle Ab seropositivity rate (94% versus 4%, p<0.001). Although there was no statistically significant difference in clinical severity and outcome or response to treatment between late-onset and early-onset patients, 50% and 75% of late-onset patients had moderate or severe disease at onset and worst status, respectively, compared to 28% and 52% for early-onset patients at onset and worst status, respectively. Also 63% of late-onset patients had disease progressed within first 3 years compared to only 40% of early-onset patients did. CONCLUSION: Nonthymoma late-onset-generalized MG patients were common among Hong Kong Chinese, with a statistically non-significant trend that it was clinically more severe than early-onset MG but with similar clinical outcome or response to treatment; >90% of these patients were seropositive for striated muscle Ab.
Assuntos
Povo Asiático/estatística & dados numéricos , Miastenia Gravis/epidemiologia , Adolescente , Adulto , Idade de Início , Autoanticorpos/sangue , Criança , Pré-Escolar , Feminino , Hong Kong/epidemiologia , Humanos , Masculino , Placa Motora/metabolismo , Músculo Esquelético/metabolismo , Miastenia Gravis/diagnóstico , Miastenia Gravis/terapia , Receptores Nicotínicos/imunologia , Estudos Retrospectivos , Índice de Gravidade de DoençaRESUMO
Acute transverse myelitis (ATM) is commonly para-infectious. Recurrent ATM occurs in connective tissue diseases (CTD), infective myelitis and idiopathic inflammatory demyelinating disorders (IIDD) including multiple sclerosis (MS) and neuromyelitis optica (NMO). Previous studies might include NMO and idiopathic recurrent transverse myelitis (IRTM) as MS. The aim was to study the outcome of patients after a first attack of idiopathic ATM. Idiopathic ATM patients over a 6-year period were retrospectively studied. Known causes of myelopathy were excluded. Among 32 patients studied, 20 (63%) had single ATM attack upon follow up for 39-93 months, three developed recurrent ATM related to CTD (two systemic lupus erythematosus and one anti-Ro antibody positive) and nine (28.1%) developed recurrent neuroinflammation compatible with IIDD. Among IIDD patients, three had NMO, two restricted variant of NMO, three IRTM and one classical MS. NMO, its variant and IRTM had mean spinal MRI abnormality of 3.7, 2.1 and 3.9 vertebral segments respectively while non-recurrent ATM had 1.6 vertebral segments. Four (80%) of the five patients with NMO or its variant had poor neurological prognosis versus only one (5%) of non-recurrent ATM patients. IRTM patients had advanced mean onset age, 62 years vs. 43 years for non-recurrent ATM patients. In IIDD patients presenting with ATM as first attack of neuroinflammation, NMO and its variant (56%) were most frequent, then IRTM (33%), with classical MS (11%) the rarest. As long-term treatments for NMO are different from MS, early recognition of NMO and its variant is important for prevention of serious neurological deficits.
Assuntos
Doenças Desmielinizantes/etiologia , Mielite Transversa/complicações , Adulto , Idoso , Antivirais/uso terapêutico , Encéfalo/patologia , Encéfalo/virologia , Doenças Desmielinizantes/diagnóstico , Doenças Desmielinizantes/terapia , Progressão da Doença , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Mielite Transversa/diagnóstico , Mielite Transversa/fisiopatologia , Mielite Transversa/terapia , Estudos RetrospectivosRESUMO
Myopia has become an almost pandemic problem in many populations. There are compelling evidence to suggest that myopia is a hereditary condition. However, myopia would constitute a definite selection disadvantage during most stages of human evolution, which is incompatible with its moderate to high prevalence in most modern populations. The rapid upsurge of myopia over just a few decades also implies that its inheritance does not follow any of the usual patterns, and environmental factors may have an important role in precipitating its occurrence in those who are genetically predisposed. Previous studies showed that myopes were, on average, more intelligent than non-myopes, and this association had been attributed to a biological link between eye growth and brain development. We propose a pleiotropic genetic model to explain the atypical epidemiologic and inheritance pattern of myopia and its relationship with neurocognitive development. This pleiotropic gene was positively selected for its facilitation of human intelligence. The myopic component is a latent phenotype; myopia will not be expressed unless some novel external factors are encountered (i.e. a "quirk" phenomenon). Therefore, the myopic component was selectively neutral in our ancestral environment. The net gain in Darwinian fitness enables the pleiotropic gene to attain a high frequency in the human population, as reflected by our current prevalence of myopia.
Assuntos
Evolução Biológica , Encéfalo/fisiologia , Cognição/fisiologia , Meio Ambiente , Regulação da Expressão Gênica no Desenvolvimento/genética , Inteligência/genética , Miopia/genética , Animais , Humanos , Fenótipo , Seleção GenéticaRESUMO
OBJECTIVES: Previous studies reported inconsistent findings about the effects of footwear on running economy, which is a surrogate measure of running performance. This meta-analytical review compared the running economy between running in barefoot, minimalists, and standard running shoes. DESIGN: Meta-analysis. METHODS: Electronic searches on MEDLINE, CINAHL, SPORTDiscus, and Cochrane Library databases were performed and the reference lists of the screened articles were also scrutinized. Two reviewers screened clinical trials that measured the oxygen cost of runners in different footwear conditions. RESULTS: Thirteen studies were selected in this meta-analysis with a total of 168 runners included. Barefoot running was shown to be more economic than shod running (p<0.01; standardized mean difference=-0.43; 95% Confidence Interval=-0.21 to -0.64; Z=3.96). Similar pattern was found when comparing minimalist and shoe (p<0.01; standardized mean difference=-0.49; 95% Confidence Interval=-0.29 to -0.70; Z=4.64). The observed changes were of small effect. Conversely, no significant difference in the metabolic cost was found between running in minimalists and barefoot running (p=0.45). CONCLUSIONS: Barefoot running or running in minimalist may require lower utilization of oxygen than shod running. Theoretically, the lower oxygen cost may improve long distance running performance. However, more than half of the runners in the included studies had previous barefoot experience and the findings may not apply to those habitual shod runners who are undergoing the transition. In addition, high risk of bias was reported in the included studies and quality study in the future is still warranted.
Assuntos
Consumo de Oxigênio , Corrida/fisiologia , Sapatos , Fenômenos Biomecânicos , Pé , HumanosRESUMO
OBJECTIVES: Kinesio tape (KT) is a commonly used intervention in sports. It claims to be able to alter the muscle activity, in terms of both facilitation and inhibition, by certain application methods. This study compared the neuromuscular activity of the wrist extensor muscles and maximal grip strength with facilitatory, inhibitory KT, and tapeless condition in healthy adults who were ignorant about KT. Potential placebo effects were eliminated by deception. DESIGN: Randomized deceptive trial. METHODS: 33 participants performed maximal grip assessment in a randomly assigned order of three taping conditions: true facilitatory KT, inhibitory KT, and no tape. The participants were blindfolded during the evaluation. Under the pretense of applying a series of adhesive muscle sensors, KT was applied to their wrist extensor muscles of the dominant forearm in the first two conditions. Within-subject comparisons of normalized root mean square of the wrist extensors electromyographic activity and maximal grip strength were conducted across three taping conditions. RESULTS: 31 out of 33 enlisted participants were confirmed to be ignorant about KT. No significant differences were found in the maximum grip strength (p=0.394), electromyographic activity (p=0.276), and self-perceived performance (p=0.825) between facilitatory KT, inhibitory KT, and tapeless conditions. CONCLUSIONS: Neither facilitatory nor inhibitory effects were observed between different application techniques of KT in healthy participants. Clinically, alternative method should be used for muscle activity modulation.
Assuntos
Fita Atlética , Antebraço/fisiologia , Força da Mão/fisiologia , Músculo Esquelético/fisiologia , Punho/fisiologia , Adulto , Eletromiografia , Feminino , Voluntários Saudáveis , Humanos , MasculinoRESUMO
OBJECTIVES: Plantar fasciitis, a common injury in runners, has been speculated to be associated with weakness of the intrinsic foot muscles. A recent study reported that atrophy of the intrinsic forefoot muscles might contribute to plantar fasciitis by destabilizing the medial longitudinal arch. However, intrinsic foot muscle volume difference between individuals with plantar fasciitis and healthy counterparts remains unknown. This study examined the relationship of intrinsic foot muscle volume and incidence of plantar fasciitis. DESIGN: Case-control study. METHODS: 20 experienced (≥5 years) runners were recruited. Ten of them had bilateral chronic (≥2 years) plantar fasciitis while the others were healthy characteristics-matched runners. Intrinsic muscle volumes of the participants' right foot were scanned with a 1.5T magnetic resonance system and segmented using established methods. Body-mass normalized intrinsic foot muscle volumes were compared between runners with and without chronic plantar fasciitis. RESULTS: There was significant greater rearfoot intrinsic muscle volume in healthy runners than runners with chronic plantar fasciitis (Cohen's d=1.13; p=0.023). A similar trend was also observed in the total intrinsic foot muscle volume but it did not reach a statistical significance (Cohen's d=0.92; p=0.056). Forefoot volume was similar between runners with and without plantar fasciitis. CONCLUSIONS: These results suggest that atrophy of intrinsic foot muscles may be associated with symptoms of plantar fasciitis in runners. These findings may provide useful information in rehabilitation strategies of chronic plantar fasciitis.
Assuntos
Fasciíte Plantar/patologia , Músculo Esquelético/anatomia & histologia , Corrida , Adulto , Fenômenos Biomecânicos , Estudos de Casos e Controles , Fasciíte Plantar/diagnóstico por imagem , Fasciíte Plantar/etiologia , Feminino , Pé , Humanos , Imageamento por Ressonância Magnética , Masculino , Músculo Esquelético/patologia , Atrofia Muscular/complicações , Atrofia Muscular/patologia , AutorrelatoRESUMO
BACKGROUND: Tibial stress fracture is a common injury in runners. This condition has been associated with increased impact loading. Since vertical loading rates are related to the landing pattern, many heelstrike runners attempt to modify their footfalls for a lower risk of tibial stress fracture. Such effect of modified landing pattern remains unknown. This study examined the immediate effects of landing pattern modification on the probability of tibial stress fracture. METHODS: Fourteen experienced heelstrike runners ran on an instrumented treadmill and they were given augmented feedback for landing pattern switch. We measured their running kinematics and kinetics during different landing patterns. Ankle joint contact force and peak tibial strains were estimated using computational models. We used an established mathematical model to determine the effect of landing pattern on stress fracture probability. FINDINGS: Heelstrike runners experienced greater impact loading immediately after landing pattern switch (P<0.004). There was an increase in the longitudinal ankle joint contact force when they landed with forefoot (P=0.003). However, there was no significant difference in both peak tibial strains and the risk of tibial stress fracture in runners with different landing patterns (P>0.986). INTERPRETATION: Immediate transitioning of the landing pattern in heelstrike runners may not offer timely protection against tibial stress fracture, despite a reduction of impact loading. Long-term effects of landing pattern switch remains unknown.
Assuntos
Fraturas de Estresse/prevenção & controle , Marcha/fisiologia , Corrida/lesões , Fraturas da Tíbia/prevenção & controle , Adulto , Articulação do Tornozelo/fisiologia , Fenômenos Biomecânicos , Simulação por Computador , Teste de Esforço , Feminino , Pé/fisiologia , Fraturas de Estresse/fisiopatologia , Humanos , Masculino , Modelos Estatísticos , Fatores de Risco , Fraturas da Tíbia/fisiopatologiaRESUMO
BACKGROUND: Kinesiology tape (KINTAPE) is one of the most common adhesive therapeutic tapes. Apart from clinical applications, KINTAPE claims to be able to enhance functional performance by muscle activity facilitation. However, emerging evidence suggests that the isokinetic muscle strength remains similar when the placebo effect is eliminated. OBJECTIVES: In view of the weak relationship between functional performance and isokinetic muscle strength, this study investigated the true effects of KINTAPE on functional performance. DESIGN: Deceptive, randomized, and crossover trial. METHOD: Sixty four experienced volleyball players performed vertical jumping test under three taping conditions: true facilitative KINTAPE, sham KINTAPE, and no KINTAPE. Under the pretense of applying adhesive muscle sensors, KINTAPE was applied to their quadriceps and gastrocnemius in the first two conditions. Mean maximum jump height and peak jump power were averaged from three attempts. Within-subject comparisons were conducted by repeated measure ANOVA. RESULTS: Out of 64 participants, 30 of them were successfully deceived and they were ignorant about KINTAPE. No significant differences were found in both maximum jump height (η(2) = 0.001; p = 0.241) and peak jump power (η(2) = 0.001; p = 0.134) between three taping conditions. CONCLUSIONS: The results showed that KINTAPE did not facilitate muscle performance by generating higher jumping power or yielding a better jumping performance. These findings reinforce that previously reported muscle facilitatory effects or functional enhancement using KINTAPE may be attributed to placebo effects.
Assuntos
Traumatismos em Atletas/terapia , Fita Atlética , Força Muscular/fisiologia , Músculo Esquelético/fisiologia , Músculo Quadríceps/fisiologia , Voleibol , Adolescente , Estudos Cross-Over , Feminino , Humanos , Masculino , Efeito Placebo , Adulto JovemRESUMO
The pattern of cerebral atherosclerosis is not the same among different races. White patients rarely have intracranial large arterial steno-occlusive disease even if their systemic arteries are extensively involved, while non-white patients frequently have their intracranial arteries affected. We postulate that during human population diversification, those who settled in Europe had acquired a stroke-suppressor genotype that increases their resistance against atherogenesis, but with protection confined to the intracranial large arteries. The contemporary affluent lifestyle accelerates the development of atherosclerosis. In the whites, it involves the whole arterial bed except the intracranial vessels. People living in non-Western countries used to have a healthier way of living. They did not develop significant atherosclerotic diseases until recently when a westernised lifestyle was adopted. Unlike the whites, their intracranial arteries will not be spared. Atherosclerosis has become a major cause of premature mortality in the modern world, and an anti-atherogenic mechanism would confer a selection advantage. With further adaptive intensification, this protection may extend to the rest of the arterial bed. As a result, future Homo sapiens will be able to tolerate an affluent lifestyle without much adverse sequel such as premature vascular death. Alternatively, if the mediator of this anti-atherogenic mechanism can be identified and applied therapeutically, we will have an ultimate mean to prevent atherosclerosis.
Assuntos
Evolução Biológica , Artérias Cerebrais/metabolismo , Arteriosclerose Intracraniana/genética , Estilo de Vida , População Branca/genética , Antioxidantes/metabolismo , Humanos , Fatores de RiscoRESUMO
Cerebral venous thrombosis (CVT) is an uncommon but serious type of stroke. Thrombosis may involve the cortical or deep veins or the venous sinuses. The presenting clinical features are non-specific. We report a 48-year-old man with CVT who presented with fever, bitemporal throbbing headache, and generalised convulsion. Computed tomography (CT) of the brain revealed acute haemorrhages over right anterior frontal and posterior temporal regions with surrounding oedema and right anterior temporal subcortical oedema. The initial diagnosis was herpes simplex encephalitis. Absence of venous flow over the right transverse and sigmoid sinuses during the venous phase of digital subtraction angiography (DSA) revealed CVT. He was anti-coagulated for 6 months. An underlying cause of CVT was not detected. A high index of suspicion is required when risk factors of CVT are present. CT brain may be normal or showing non-specific findings. Magnetic resonance imaging plus venography, CT venography, or DSA is diagnostic.
Assuntos
Encéfalo/irrigação sanguínea , Febre/etiologia , Hemorragias Intracranianas/etiologia , Trombose Intracraniana/patologia , Convulsões/etiologia , Trombose Venosa/patologia , Angiografia Digital , Anticoagulantes/uso terapêutico , Diagnóstico Diferencial , Encefalite por Herpes Simples/patologia , Lobo Frontal/patologia , Heparina de Baixo Peso Molecular/uso terapêutico , Humanos , Hemorragias Intracranianas/patologia , Hemorragias Intracranianas/fisiopatologia , Trombose Intracraniana/complicações , Trombose Intracraniana/fisiopatologia , Masculino , Pessoa de Meia-Idade , Lobo Temporal/patologia , Tomografia Computadorizada por Raios X , Trombose Venosa/complicações , Trombose Venosa/fisiopatologia , Varfarina/uso terapêuticoRESUMO
Wilson's disease (WD) is an autosomal recessive disorder with reduced biliary excretion of copper plus impaired formation of ceruloplasmin, leading to copper accumulation in the liver, brain, kidney, and cornea. Clinical manifestations include liver damage, psychiatric symptoms, and neurological features. We report a 35-year-old woman with a history of deranged liver functions who had severe depression several years later and eventually presented with parkinsonian features. The underlying diagnosis is WD and family screening revealed WD in 2 other siblings. She could not tolerate penicillamine because of fever and leucopenia. While taking trientine hydrochloride and zinc sulphate, her parkinsonism improved and her depression remained in remission. WD should be considered in patients with unexplained liver function derangement or psychiatric symptoms. Early diagnosis and initiation of specific treatment are crucial in minimising any further cerebral and hepatic damage as well as securing possible improvement in organ functions.
Assuntos
Transtorno Depressivo/complicações , Degeneração Hepatolenticular/complicações , Transtornos Parkinsonianos/complicações , Adulto , Antiparkinsonianos/uso terapêutico , Encéfalo/patologia , Bromocriptina/uso terapêutico , Quelantes/uso terapêutico , Transtorno Depressivo/patologia , Transtorno Depressivo/psicologia , Feminino , Degeneração Hepatolenticular/patologia , Degeneração Hepatolenticular/psicologia , Humanos , Imageamento por Ressonância Magnética , Transtornos Parkinsonianos/patologia , Transtornos Parkinsonianos/psicologia , Penicilamina/uso terapêutico , Tentativa de Suicídio , Tomografia Computadorizada por Raios X , Trientina/uso terapêutico , Triexifenidil/uso terapêuticoRESUMO
OBJECTIVE: To explore the relevance of cerebrospinal fluid to serum glucose ratio in non-hypoglycorrhachic conditions. DESIGN: Retrospective observational study. SETTING: Neurology ward, university teaching hospital, Hong Kong. PATIENTS: Adult patients with conditions unrelated to hypoglycorrhachia who underwent lumbar puncture. MAIN OUTCOME MEASURES: Cerebrospinal fluid and simultaneous serum glucose concentrations, and their ratio to each other. RESULTS: Between September 1998 and August 2003, 170 cerebrospinal fluid and serum glucose samples were collected from 138 patients. Mean cerebrospinal fluid to serum glucose ratio was 0.61 (standard deviation, 0.142; range, 0.21-1.00). With the exception of cerebrospinal fluid protein level, laboratory parameters were similar among different diseases. The glucose ratio was lower than 0.6 in 43% and lower than 0.5 in 19% of samples. Cases with a low glucose ratio appeared to have higher serum glucose concentrations (significant among groups with different glucose ratios, P<0.001). The mean glucose ratio (0.65) was also significantly higher in patients with serum glucose concentration of lower than 7.8 mmol/L compared with those with serum glucose concentration between 7.8 and 11.1 mmol/L (mean, 0.46), or higher than 11.1 mmol/L (mean, 0.46) [P<0.001]. There was a strong negative correlation between the glucose ratio and serum glucose concentration (r= -0.704, P<0.001). CONCLUSION: A lowered cerebrospinal fluid to serum glucose ratio is often seen in the absence of an appropriate disorder, especially when simultaneous serum glucose concentration is elevated. This may be explained by the saturation kinetics of glucose transportation in hyperglycaemia, and the time lag for cerebrospinal fluid and glucose to equilibrate when the blood level fluctuates.
Assuntos
Glicemia/análise , Líquido Cefalorraquidiano/química , Glucose/metabolismo , Doenças do Sistema Nervoso/diagnóstico , Punção Espinal , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise por Conglomerados , Diabetes Mellitus/diagnóstico , Diagnóstico Diferencial , Feminino , Hong Kong , Hospitais de Ensino , Humanos , Hiperglicemia/diagnóstico , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
Barefoot running has been proposed to reduce vertical loading rates, which is a risk factor of running injuries. Most of the previous studies evaluated runners on level surfaces. This study examined the effect of surface inclination on vertical loading rates and landing pattern during the first attempt of barefoot running among habitual shod runners. Twenty habitual shod runners were asked to run on treadmill at 8.0 km/h at three inclination angles (0°; +10°; -10°) with and without their usual running shoes. Vertical average rate (VALR) and instantaneous loading rate (VILR) were obtained by established methods. Landing pattern was decided using high-speed camera. VALR and VILR in shod condition were significantly higher (p < 0.001) in declined than in level or inclined treadmill running, but not in barefoot condition (p > 0.382). There was no difference (p > 0.413) in the landing pattern among all surface inclinations. Only one runner demonstrated complete transition to non-heel strike landing in all slope conditions. Reducing heel strike ratio in barefoot running did not ensure a decrease in loading rates (p > 0.15). Conversely, non-heel strike landing, regardless of footwear condition, would result in a softer landing (p < 0.011).
Assuntos
Pé/fisiologia , Corrida/fisiologia , Adulto , Fenômenos Biomecânicos , Teste de Esforço , Feminino , Humanos , Masculino , Suporte de Carga/fisiologiaRESUMO
Kinesiology tape (KinTape) is a therapeutic tape without much understanding of its mechanism. KinTape claims to increase cutaneous stimulation, which facilitates motor unit firing, and consequently improves functional performance; however these, benefits could be due to placebo effects. This study investigated the true effects of KinTape by a deceptive, randomized, and controlled trial. Thirty healthy participants performed isokinetic testing of three taping conditions: true facilitative KinTape, sham KinTape, and no KinTape. The participants were blindfolded during the evaluation. Under the pretense of applying adhesive muscle sensors, KinTape was applied to their quadriceps in the first two conditions. Normalized peak torque, normalized total work, and time to peak torque were measured at two angular speeds (60°/s and 180°/s) and analyzed with one-way repeated measures ANOVA. Participants were successfully deceived and they were ignorant about KinTape. No significant differences were found between normalized peak torque, normalized total work, and time to peak torque at 60°/s or 180°/s (p = 0.31-0.99) between three taping conditions. The results showed that KinTape did not facilitate muscle performance in generating higher peak torque, yielding a greater total work, or inducing an earlier onset of peak torque. These findings suggest that previously reported muscle facilitatory effects using KinTape may be attributed to placebo effects.