The search for plant activity against tuberculosis using breakpoints: A review.

The present study proposes a discussion about the use of breakpoints when plant derivatives are used for investigating potential agents against Mycobacterium tuberculosis strains. A systematic review on these aspects was performed and supported that an arbitrary breakpoint may be considered inadequate in this kind of study. In addition, we propose that the adoption of this limiter should be done from the toxicity value found using the same plant derivative.