Nanomedicine-based neuroprotective strategies in patient specific-iPSC and personalized medicine.

In recent decades, nanotechnology has attracted major interests in view of drug delivery systems and therapies against diseases, such as cancer, neurodegenerative diseases, and many others. Nanotechnology provides the opportunity for nanoscale particles or molecules (so called "Nanomedicine") to be delivered to the targeted sites, thereby, reducing toxicity (or side effects) and improving drug bioavailability. Nowadays, a great deal of nano-structured particles/vehicles has been discovered, including polymeric nanoparticles, lipid-based nanoparticles, and mesoporous silica nanoparticles. Nanomedical utilizations have already been well developed in many different aspects, including disease treatment, diagnostic, medical devices designing, and visualization (i.e., cell trafficking). However, while quite a few successful progressions on chemotherapy using nanotechnology have been developed, the implementations of nanoparticles on stem cell research are still sparsely populated. Stem cell applications and therapies are being considered to offer an outstanding potential in the treatment for numbers of maladies. Human induced pluripotent stem cells (iPSCs) are adult cells that have been genetically reprogrammed to an embryonic stem cell-like state. Although the exact mechanisms underlying are still unclear, iPSCs are already being considered as useful tools for drug development/screening and modeling of diseases. Recently, personalized medicines have drawn great attentions in biological and pharmaceutical studies. Generally speaking, personalized medicine is a therapeutic model that offers a customized healthcare/cure being tailored to a specific patient based on his own genetic information. Consequently, the combination of nanomedicine and iPSCs could actually be the potent arms for remedies in transplantation medicine and personalized medicine. This review will focus on current use of nanoparticles on therapeutical applications, nanomedicine-based neuroprotective manipulations in patient specific-iPSCs and personalized medicine.

Study of microcomb threshold power with coupling scaling.

We model the generation threshold and conversion efficiency of microcombs by scaling the cavity coupling. With the Lugiato-Lefever equation (LLE), quantitative analysis of threshold is established in the parameter space of pump power and coupling. Considering the large detuning and Kerr-induced phase shift, the threshold power is numerically solved with the minimum at over-coupling, in agreement with that from the traveling wave theory. Furthermore, the coupling dependence on microcomb generation is discussed, providing the accessibility of high-efficient, stable combs (≥ 40%) around the threshold. This work offers universal guidelines for the design of microcombs with low-power and high-efficient operation.