Detalhe da pesquisa
1.
From complex data to biological insight: 'DEKER' feature selection and network inference.
J Pharmacokinet Pharmacodyn
; 49(1): 81-99, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34791577
2.
Two heads are better than one: current landscape of integrating QSP and machine learning : An ISoP QSP SIG white paper by the working group on the integration of quantitative systems pharmacology and machine learning.
J Pharmacokinet Pharmacodyn
; 49(1): 5-18, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35103884
3.
Effect of letermovir on levonorgestrel and ethinyl estradiol pharmacokineticsâ©.
Int J Clin Pharmacol Ther
; 57(9): 450-457, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31232280
4.
Developing a mechanistic understanding of the nonlinear pharmacokinetics of letermovir and prospective drug interaction with everolimus using physiological-based pharmacokinetic modeling.
Clin Transl Sci
; 16(6): 1039-1048, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37085998
5.
Exposure-Response Analyses of Letermovir Following Oral and Intravenous Administration in Allogeneic Hematopoietic Cell Transplantation Recipients.
Clin Pharmacol Ther
; 111(2): 485-495, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34674258
6.
Drug-Drug Interaction of Letermovir and Atorvastatin in Healthy Participants.
Clin Pharmacol Drug Dev
; 11(4): 420-428, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35157785
7.
Population pharmacokinetics of letermovir following oral and intravenous administration in healthy participants and allogeneic hematopoietic cell transplantation recipients.
CPT Pharmacometrics Syst Pharmacol
; 10(3): 255-267, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33440077
8.
A Model-Informed Drug Discovery and Development Strategy for the Novel Glucose-Responsive Insulin MK-2640 Enabled Rapid Decision Making.
Clin Pharmacol Ther
; 107(6): 1296-1311, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31889297
9.
PBPK Modeling Strategy for Predicting Complex Drug Interactions of Letermovir as a Perpetrator in Support of Product Labeling.
Clin Pharmacol Ther
; 105(2): 515-523, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29901213
10.
Pharmacogenetic Analysis of OATP1B1, UGT1A1, and BCRP Variants in Relation to the Pharmacokinetics of Letermovir in Previously Conducted Clinical Studies.
J Clin Pharmacol
; 59(9): 1236-1243, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31022310
11.
Pharmacokinetic Drug-Drug Interactions Between Letermovir and the Immunosuppressants Cyclosporine, Tacrolimus, Sirolimus, and Mycophenolate Mofetil.
J Clin Pharmacol
; 59(10): 1331-1339, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30990905
12.
Pharmacokinetics and Tolerability of Letermovir Coadministered With Azole Antifungals (Posaconazole or Voriconazole) in Healthy Subjects.
J Clin Pharmacol
; 58(7): 897-904, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29578577
13.
Prediction of graft-versus-host disease in humans by donor gene-expression profiling.
PLoS Med
; 4(1): e23, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17378698
14.
The application of systems biology to drug discovery.
Curr Opin Chem Biol
; 10(4): 294-302, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16822703
15.
Perspectives on training quantitative systems pharmacologists.
CPT Pharmacometrics Syst Pharmacol
; 11(6): 669-672, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35388628
16.
Response to continuous and pulsatile PTH dosing: a mathematical model for parathyroid hormone receptor kinetics.
Bone
; 37(2): 159-69, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15921971
17.
Using in silico biology to facilitate drug development.
Novartis Found Symp
; 247: 222-38; discussion 238-43, 244-52, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12539958
18.
Verification of systems biology research in the age of collaborative competition.
Nat Biotechnol
; 29(9): 811-5, 2011 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21904331
19.
Modeling the interactions between osteoblast and osteoclast activities in bone remodeling.
J Theor Biol
; 229(3): 293-309, 2004 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15234198