Pesquisa | BVS IEC

1.

Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes.

Marsiglia, William M; Chow, Arthur; Khan, Zaigham M; He, Liu; Dar, Arvin C.

Nat Chem Biol ; 20(3): 373-381, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-37919548

2.

Structural basis for the action of the drug trametinib at KSR-bound MEK.

Khan, Zaigham M; Real, Alexander M; Marsiglia, William M; Chow, Arthur; Duffy, Mary E; Yerabolu, Jayasudhan R; Scopton, Alex P; Dar, Arvin C.

Nature ; 588(7838): 509-514, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-32927473

3.

Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals.

Jee, David; Yang, Jr-Shiuan; Park, Sun-Mi; Farmer, D'Juan T; Wen, Jiayu; Chou, Timothy; Chow, Arthur; McManus, Michael T; Kharas, Michael G; Lai, Eric C.

Mol Cell ; 69(2): 265-278.e6, 2018 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-29351846

4.

Conformational control and regulation of the pseudokinase KSR via small molecule binding interactions.

Chow, Arthur; Khan, Zaigham M; Marsiglia, William M; Dar, Arvin C.

Methods Enzymol ; 667: 365-402, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35525547

5.

Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.

Prieto, Camila; Nguyen, Diu T T; Liu, Zhaoqi; Wheat, Justin; Perez, Alexendar; Gourkanti, Saroj; Chou, Timothy; Barin, Ersilia; Velleca, Anthony; Rohwetter, Thomas; Chow, Arthur; Taggart, James; Savino, Angela M; Hoskova, Katerina; Dhodapkar, Meera; Schurer, Alexandra; Barlowe, Trevor S; Vu, Ly P; Leslie, Christina; Steidl, Ulrich; Rabadan, Raul; Kharas, Michael G.

Nat Cancer ; 2: 741-757, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34458856

6.

IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.

Park, Sun-Mi; Cho, Hyunwoo; Thornton, Angela M; Barlowe, Trevor S; Chou, Timothy; Chhangawala, Sagar; Fairchild, Lauren; Taggart, James; Chow, Arthur; Schurer, Alexandria; Gruet, Antoine; Witkin, Matthew D; Kim, Jun Hyun; Shevach, Ethan M; Krivtsov, Andrei; Armstrong, Scott A; Leslie, Christina; Kharas, Michael G.

Cell Stem Cell ; 24(1): 153-165.e7, 2019 01 03.

Artigo em Inglês | MEDLINE | ID: mdl-30472158

7.

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.

Minuesa, Gerard; Albanese, Steven K; Xie, Wei; Kazansky, Yaniv; Worroll, Daniel; Chow, Arthur; Schurer, Alexandra; Park, Sun-Mi; Rotsides, Christina Z; Taggart, James; Rizzi, Andrea; Naden, Levi N; Chou, Timothy; Gourkanti, Saroj; Cappel, Daniel; Passarelli, Maria C; Fairchild, Lauren; Adura, Carolina; Glickman, J Fraser; Schulman, Jessica; Famulare, Christopher; Patel, Minal; Eibl, Joseph K; Ross, Gregory M; Bhattacharya, Shibani; Tan, Derek S; Leslie, Christina S; Beuming, Thijs; Patel, Dinshaw J; Goldgur, Yehuda; Chodera, John D; Kharas, Michael G.

Nat Commun ; 10(1): 2691, 2019 06 19.

Artigo em Inglês | MEDLINE | ID: mdl-31217428

8.

The N⁶-methyladenosine (m⁶A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.

Vu, Ly P; Pickering, Brian F; Cheng, Yuanming; Zaccara, Sara; Nguyen, Diu; Minuesa, Gerard; Chou, Timothy; Chow, Arthur; Saletore, Yogesh; MacKay, Matthew; Schulman, Jessica; Famulare, Christopher; Patel, Minal; Klimek, Virginia M; Garrett-Bakelman, Francine E; Melnick, Ari; Carroll, Martin; Mason, Christopher E; Jaffrey, Samie R; Kharas, Michael G.

Nat Med ; 23(11): 1369-1376, 2017 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-28920958

9.

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

Kotini, Andriana G; Chang, Chan-Jung; Chow, Arthur; Yuan, Han; Ho, Tzu-Chieh; Wang, Tiansu; Vora, Shailee; Solovyov, Alexander; Husser, Chrystel; Olszewska, Malgorzata; Teruya-Feldstein, Julie; Perumal, Deepak; Klimek, Virginia M; Spyridonidis, Alexandros; Rampal, Raajit K; Silverman, Lewis; Reddy, E Premkumar; Papaemmanuil, Elli; Parekh, Samir; Greenbaum, Benjamin D; Leslie, Christina S; Kharas, Michael G; Papapetrou, Eirini P.

Cell Stem Cell ; 20(3): 315-328.e7, 2017 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-28215825

10.

Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.

Vu, Ly P; Prieto, Camila; Amin, Elianna M; Chhangawala, Sagar; Krivtsov, Andrei; Calvo-Vidal, M Nieves; Chou, Timothy; Chow, Arthur; Minuesa, Gerard; Park, Sun Mi; Barlowe, Trevor S; Taggart, James; Tivnan, Patrick; Deering, Raquel P; Chu, Lisa P; Kwon, Jeong-Ah; Meydan, Cem; Perales-Paton, Javier; Arshi, Arora; Gönen, Mithat; Famulare, Christopher; Patel, Minal; Paietta, Elisabeth; Tallman, Martin S; Lu, Yuheng; Glass, Jacob; Garret-Bakelman, Francine E; Melnick, Ari; Levine, Ross; Al-Shahrour, Fatima; Järås, Marcus; Hacohen, Nir; Hwang, Alexia; Garippa, Ralph; Lengner, Christopher J; Armstrong, Scott A; Cerchietti, Leandro; Cowley, Glenn S; Root, David; Doench, John; Leslie, Christina; Ebert, Benjamin L; Kharas, Michael G.

Nat Genet ; 49(6): 866-875, 2017 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-28436985

11.

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.

Taggart, James; Ho, Tzu-Chieh; Amin, Elianna; Xu, Haiming; Barlowe, Trevor S; Perez, Alexendar R; Durham, Benjamin H; Tivnan, Patrick; Okabe, Rachel; Chow, Arthur; Vu, Ly; Park, Sun Mi; Prieto, Camila; Famulare, Christopher; Patel, Minal; Lengner, Christopher J; Verma, Amit; Roboz, Gail; Guzman, Monica; Klimek, Virginia M; Abdel-Wahab, Omar; Leslie, Christina; Nimer, Stephen D; Kharas, Michael G.

Nat Commun ; 7: 10739, 2016 Feb 22.

Artigo em Inglês | MEDLINE | ID: mdl-26898884

12.

Isosorbide dinitrate and hydralazine in blacks with heart failure.

Chow, Arthur Y.

N Engl J Med ; 352(10): 1041-3; author reply 1041-3, 2005 Mar 10.

Artigo em Inglês | MEDLINE | ID: mdl-15761997

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Instituto Evandro Chagas

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