Detalhe da pesquisa
1.
Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition.
Int J Cancer
; 134(3): 552-62, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23852808
2.
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR).
Biochem J
; 421(1): 29-42, 2009 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19402821
3.
Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2580-4, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18378449
4.
Design and campaign synthesis of pyridine-based histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2525-9, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18378451
5.
AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules.
Mol Cancer Ther
; 14(11): 2508-18, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26358751
6.
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med Genomics
; 5: 66, 2012 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23272949
7.
Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).
Cancer Res
; 72(7): 1804-13, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22271687
8.
Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim.
PLoS One
; 5(9): e13026, 2010 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20885957
9.
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.
Cancer Res
; 70(1): 288-98, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20028854
10.
High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886).
Cancer Biol Ther
; 8(21): 2073-80, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19783898