RESUMO
The ability of fluorophotometry to measure the time course of changes in aqueous humor flow in rabbits was evaluated by measuring the effect of intravenous carbonic anhydrase inhibitors on aqueous humor flow determinations. The abrupt changes in aqueous humor flow which were found by fluorophotometry agreed well with the expected changes in aqueous humor flow calculated from the time course of the intraocular pressure. Therefore, it was concluded that fluorophotometry could measure the time course of changes in aqueous humor flow in rabbits. Furthermore, it was suggested that the initial abrupt changes in aqueous humor flow after the administration of a carbonic anhydrase inhibitor were induced by the base content of the drug, followed by a more gradual decrease in aqueous humor flow caused by the direct effect of the drug on aqueous humor formation.
Assuntos
Humor Aquoso/efeitos dos fármacos , Inibidores da Anidrase Carbônica/farmacologia , Fluorometria , Animais , Câmara Anterior/efeitos dos fármacos , Câmara Anterior/fisiologia , Humor Aquoso/fisiologia , Pressão Intraocular , CoelhosRESUMO
Topical administration of nylidrin hydrochloride lowered intraocular pressure in both albino rabbits and cynomologus monkeys. The maximum decrease occurred two hours following drug application and was unilateral. The response lasted four hours in monkeys and at least six hours in rabbits. Outflow facility, episcleral venous pressure, and aqueous humor flow measured by fluorophotometry were unaltered in both species. In rabbits in the treated eyes, ocular blood flow was increased, and anterior and posterior chamber ascorbate concentrations were unchanged. The mechanism of IOP reduction appears to be increased aqueous humor outflow via uveoscleral outflow routes that are not pressure dependent.
Assuntos
Pressão Intraocular/efeitos dos fármacos , Nilidrina/administração & dosagem , Administração Tópica , Animais , Humor Aquoso/efeitos dos fármacos , Macaca fascicularis , Coelhos , Fluxo Sanguíneo Regional/efeitos dos fármacos , Tonometria Ocular , Pressão Venosa/efeitos dos fármacosRESUMO
The advantages of the use of the operating microscope in eyelid surgery are discussed. Its use in 35 cases has yielded excellent results.
Assuntos
Doenças Palpebrais/cirurgia , Microcirurgia/métodos , Humanos , Microcirurgia/instrumentaçãoRESUMO
A new technique of binocular indirect ophthalmoscopy uses a Finhoff transilluminator, held between the observer's eyes, as the light source. The light is focused in the patient's dilated pupil through a condensing lens in a darkened room and the image is seen stereoscopically. The advantages and limitations of this technique and the optical principles are highlighted.