Detalhe da pesquisa
1.
Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop ß-cell dysfunction and metabolic syndrome.
FASEB J
; 27(10): 4122-35, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23825225
2.
Targeted over-expression of endothelin-1 in astrocytes leads to more severe brain damage and vasospasm after subarachnoid hemorrhage.
BMC Neurosci
; 14: 131, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24156724
3.
Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion.
Neurobiol Learn Mem
; 101: 46-54, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23313614
4.
Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicity.
Nucleic Acids Res
; 39(2): 475-85, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20852262
5.
The RhoA GTPase-activating protein DLC2 modulates RhoA activity and hyperalgesia to noxious thermal and inflammatory stimuli.
Neurosignals
; 20(2): 112-26, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22204965
6.
More severe type 2 diabetes-associated ischemic stroke injury is alleviated in aldose reductase-deficient mice.
J Neurosci Res
; 88(9): 2026-34, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20143423
7.
Diabetic cataracts: mechanisms and management.
Diabetes Metab Res Rev
; 26(3): 172-80, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20474067
8.
Synergistic effect of osmotic and oxidative stress in slow-developing cataract formation.
Exp Eye Res
; 87(5): 454-61, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18760274
9.
Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2.
Proteins
; 67(4): 1154-66, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17380510
10.
Deletion of aldose reductase leads to protection against cerebral ischemic injury.
J Cereb Blood Flow Metab
; 27(8): 1496-509, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17293845
11.
Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage.
Diabetes
; 55(7): 1946-53, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16804062
12.
Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease.
Neurobiol Aging
; 50: 119-133, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27960106
13.
Noninvasive monitoring of diabetes-induced cutaneous nerve fiber loss and hypoalgesia in thy1-YFP transgenic mice.
Diabetes
; 54(11): 3112-8, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16249433
14.
Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice.
Diabetes
; 54(11): 3119-25, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16249434
15.
Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves.
FASEB J
; 19(13): 1887-9, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16174787
16.
Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo.
Clin Cancer Res
; 11(16): 6002-11, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16115945
17.
Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet.
J Cereb Blood Flow Metab
; 25(8): 998-1011, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15815585
18.
Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion.
J Cereb Blood Flow Metab
; 35(10): 1687-96, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26104290
19.
Endothelial cell-specific over-expression of endothelin-1 leads to more severe cerebral damage following transient middle cerebral artery occlusion.
J Cardiovasc Pharmacol
; 44 Suppl 1: S293-300, 2004 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15838304
20.
Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion.
Life Sci
; 76(4): 445-59, 2004 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15530506