Detalhe da pesquisa
1.
Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor.
Bioorg Med Chem
; 66: 116789, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35594649
2.
1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents.
Bioorg Med Chem Lett
; 27(18): 4471-4477, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28844391
3.
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.
J Med Chem
; 67(5): 3287-3306, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38431835
4.
Corrigendum to "1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents" [Bioorg. Med. Chem. Lett. 27 (2017) 4471-4477].
Bioorg Med Chem Lett
; 28(5): 985, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29433931
5.
Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7.
J Med Chem
; 65(2): 1458-1480, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34726887
6.
Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.
J Med Chem
; 65(19): 13198-13215, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36126059
7.
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.
J Med Chem
; 64(7): 3843-3869, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33749283
8.
Synthesis and in vitro evaluation of bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis.
Bioorg Med Chem Lett
; 20(4): 1355-9, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20097069
9.
Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7.
Cancer Res
; 79(13): 3479-3491, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31064851
10.
A modular approach to marine macrolide construction. 4. Assembly of C36-C51 and C29-C44 building blocks and evaluation of key coupling reactions targeting spongistatin 1 (altohyrtin A).
Org Lett
; 9(4): 719-22, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17286379
11.
Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC.
Bioorg Med Chem Lett
; 16(4): 891-6, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16298129
12.
A new class of small molecule RNA polymerase inhibitors with activity against rifampicin-resistant Staphylococcus aureus.
Bioorg Med Chem
; 14(17): 5812-32, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759869