Detalhe da pesquisa
1.
In Vivo Biological Evaluation of a Synthetic Royleanone Derivative as a Promising Fast-Acting Trypanocidal Agent by Inducing Mitochondrial-Dependent Necrosis.
J Nat Prod
; 83(12): 3571-3583, 2020 12 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33253573
2.
Repositioning of leishmanicidal [1,2,3]Triazolo[1,5-a]pyridinium salts for Chagas disease treatment: Trypanosoma cruzi cell death involving mitochondrial membrane depolarisation and Fe-SOD inhibition.
Parasitol Res
; 119(9): 2943-2954, 2020 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-32607710
3.
Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation.
Bioorg Med Chem
; 27(17): 3902-3917, 2019 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31345745
4.
Identification of Aryl Polyamines Derivatives as Anti-Trypanosoma cruzi Agents Targeting Iron Superoxide Dismutase.
Pharmaceutics
; 15(1)2022 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36678771
5.
Three-Finger Toxins from Brazilian Coral Snakes: From Molecular Framework to Insights in Biological Function.
Toxins (Basel)
; 13(5)2021 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33946590
6.
Building a MCHR1 homology model provides insight into the receptor-antagonist contacts that are important for the development of new anti-obesity agents.
Bioorg Med Chem
; 18(21): 7365-79, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20932767
7.
Aerolysin nanopores decode digital information stored in tailored macromolecular analytes.
Sci Adv
; 6(50)2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33298438
8.
Single-molecule sensing of peptides and nucleic acids by engineered aerolysin nanopores.
Nat Commun
; 10(1): 4918, 2019 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31664022
9.
A step towards development of promising trypanocidal agents: Synthesis, characterization and in vitro biological evaluation of ferrocenyl Mannich base-type derivatives.
Eur J Med Chem
; 163: 569-582, 2019 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30554132
10.
Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity.
Curr Med Chem
; 15(10): 1025-43, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18393860
11.
Mapping the sensing spots of aerolysin for single oligonucleotides analysis.
Nat Commun
; 9(1): 2823, 2018 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30026547
12.
Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi.
J Med Chem
; 61(13): 5643-5663, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29883536
13.
Structural, physicochemical and dynamic features conserved within the aerolysin pore-forming toxin family.
Sci Rep
; 7(1): 13932, 2017 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29066778
14.
Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process.
Nat Commun
; 7: 12062, 2016 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27405240
15.
In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.
J Med Chem
; 59(24): 10929-10945, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002965
16.
Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies.
Eur J Med Chem
; 52: 1-13, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22444026
17.
Correction to In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.
J Med Chem
; 60(6): 2604, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28257207
18.
New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
Arzneimittelforschung
; 58(11): 585-91, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-19137910
19.
Novel series of substituted biphenylmethyl urea derivatives as MCH-R1 antagonists for the treatment of obesity.
Bioorg Med Chem
; 15(11): 3896-911, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17407817