Pesquisa | BVS IEC

1.

Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS.

Hu, Yeguang; Salgado Figueroa, Daniela; Zhang, Zhihong; Veselits, Margaret; Bhattacharyya, Sourya; Kashiwagi, Mariko; Clark, Marcus R; Morgan, Bruce A; Ay, Ferhat; Georgopoulos, Katia.

Cell ; 186(24): 5269-5289.e22, 2023 11 22.

Artigo em Inglês | MEDLINE | ID: mdl-37995656

2.

BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin.

Mandal, Malay; Maienschein-Cline, Mark; Hu, Yeguang; Mohsin, Azam; Veselits, Margaret L; Wright, Nathaniel E; Okoreeh, Michael K; Yoon, Young Me; Veselits, Jacob; Georgopoulos, Katia; Clark, Marcus R.

Nat Immunol ; 25(1): 129-141, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-37985858

3.

The endogenous repertoire harbors self-reactive CD4⁺ T cell clones that adopt a follicular helper T cell-like phenotype at steady state.

Lee, Victoria; Rodriguez, Donald M; Ganci, Nicole K; Zeng, Sharon; Ai, Junting; Chao, Jaime L; Walker, Matthew T; Miller, Christine H; Klawon, David E J; Schoenbach, Mary H; Kennedy, Domenick E; Maienschein-Cline, Mark; Socci, Nicholas D; Clark, Marcus R; Savage, Peter A.

Nat Immunol ; 24(3): 487-500, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36759711

4.

Novel specialized cell state and spatial compartments within the germinal center.

Kennedy, Domenick E; Okoreeh, Michael K; Maienschein-Cline, Mark; Ai, Junting; Veselits, Margaret; McLean, Kaitlin C; Dhungana, Yogesh; Wang, Hong; Peng, Junmin; Chi, Hongbo; Mandal, Malay; Clark, Marcus R.

Nat Immunol ; 21(6): 660-670, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32341509

5.

Quantifying in situ adaptive immune cell cognate interactions in humans.

Liarski, Vladimir M; Sibley, Adam; van Panhuys, Nicholas; Ai, Junting; Chang, Anthony; Kennedy, Domenick; Merolle, Maria; Germain, Ronald N; Giger, Maryellen L; Clark, Marcus R.

Nat Immunol ; 20(4): 503-513, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30778242

6.

CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis.

Mandal, Malay; Okoreeh, Michael K; Kennedy, Domenick E; Maienschein-Cline, Mark; Ai, Junting; McLean, Kaitlin C; Kaverina, Natalya; Veselits, Margaret; Aifantis, Iannis; Gounari, Fotini; Clark, Marcus R.

Nat Immunol ; 20(10): 1393-1403, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31477919

7.

RAG Represents a Widespread Threat to the Lymphocyte Genome.

Teng, Grace; Maman, Yaakov; Resch, Wolfgang; Kim, Min; Yamane, Arito; Qian, Jason; Kieffer-Kwon, Kyong-Rim; Mandal, Malay; Ji, Yanhong; Meffre, Eric; Clark, Marcus R; Cowell, Lindsay G; Casellas, Rafael; Schatz, David G.

Cell ; 162(4): 751-65, 2015 Aug 13.

Artigo em Inglês | MEDLINE | ID: mdl-26234156

8.

Self-reactive IgE exacerbates interferon responses associated with autoimmunity.

Henault, Jill; Riggs, Jeffrey M; Karnell, Jodi L; Liarski, Vladimir M; Li, Jianqing; Shirinian, Lena; Xu, Linda; Casey, Kerry A; Smith, Michael A; Khatry, Deepak B; Izhak, Liat; Clarke, Lorraine; Herbst, Ronald; Ettinger, Rachel; Petri, Michelle; Clark, Marcus R; Mustelin, Tomas; Kolbeck, Roland; Sanjuan, Miguel A.

Nat Immunol ; 17(2): 196-203, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26692173

9.

Histone reader BRWD1 targets and restricts recombination to the Igk locus.

Mandal, Malay; Hamel, Keith M; Maienschein-Cline, Mark; Tanaka, Azusa; Teng, Grace; Tuteja, Jigyasa H; Bunker, Jeffrey J; Bahroos, Neil; Eppig, John J; Schatz, David G; Clark, Marcus R.

Nat Immunol ; 16(10): 1094-103, 2015 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-26301565

10.

Molecular mechanisms insulating proliferation from genotoxic stress in B lymphocytes.

Wright, Nathaniel E; Mandal, Malay; Clark, Marcus R.

Trends Immunol ; 44(9): 668-677, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37573227

11.

PI3KÎ´: Too much of a good thing.

Kennedy, Domenick E; Clark, Marcus R.

Nat Immunol ; 19(9): 910-911, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-30127436

12.

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation.

Ochiai, Kyoko; Maienschein-Cline, Mark; Mandal, Malay; Triggs, Joseph R; Bertolino, Eric; Sciammas, Roger; Dinner, Aaron R; Clark, Marcus R; Singh, Harinder.

Nat Immunol ; 13(3): 300-7, 2012 Jan 22.

Artigo em Inglês | MEDLINE | ID: mdl-22267219

13.

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2.

Mandal, Malay; Powers, Sarah E; Maienschein-Cline, Mark; Bartom, Elizabeth T; Hamel, Keith M; Kee, Barbara L; Dinner, Aaron R; Clark, Marcus R.

Nat Immunol ; 12(12): 1212-20, 2011 Oct 30.

Artigo em Inglês | MEDLINE | ID: mdl-22037603

14.

Artificial Intelligence and Cellular Segmentation in Tissue Microscopy Images.

Durkee, Madeleine S; Abraham, Rebecca; Clark, Marcus R; Giger, Maryellen L.

Am J Pathol ; 191(10): 1693-1701, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-34129842

15.

Cellular aspects of the pathogenesis of lupus nephritis.

Chang, Anthony; Clark, Marcus R; Ko, Kichul.

Curr Opin Rheumatol ; 33(2): 197-204, 2021 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-33394604

16.

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.

Mandal, Malay; Powers, Sarah E; Ochiai, Kyoko; Georgopoulos, Katia; Kee, Barbara L; Singh, Harinder; Clark, Marcus R.

Nat Immunol ; 10(10): 1110-7, 2009 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-19734904

17.

Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu.

Zhang, Dongdong; Kinloch, Andrew J; Srinath, Abhinav; Shenkar, Robert; Girard, Romuald; Lightle, Rhonda; Moore, Thomas; Koskimäki, Janne; Mohsin, Azam; Carrión-Penagos, Julián; Romanos, Sharbel; Shen, Le; Clark, Marcus R; Shi, Changbin; Awad, Issam A.

J Autoimmun ; 113: 102469, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32362501

18.

EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints.

Jacobsen, Jennifer A; Woodard, Jennifer; Mandal, Malay; Clark, Marcus R; Bartom, Elizabeth T; Sigvardsson, Mikael; Kee, Barbara L.

J Immunol ; 198(12): 4682-4691, 2017 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-28490575

19.

Flippin' lipids.

Clark, Marcus R.

Nat Immunol ; 12(5): 373-5, 2011 May.

Artigo em Inglês | MEDLINE | ID: mdl-21502987

20.

Corrigendum to "Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu" [J. Autoimmun. 113 (2020) 102469].