Detalhe da pesquisa
1.
Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds.
Am J Physiol Regul Integr Comp Physiol
; 317(6): R921-R931, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31664867
2.
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Biophys J
; 108(6): 1400-1413, 2015 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809253
3.
Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.
Biophys J
; 106(5): 1057-69, 2014 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24606930
4.
Proton sensors in the pore domain of the cardiac voltage-gated sodium channel.
J Biol Chem
; 288(7): 4782-91, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23283979
5.
Regional flexibility in the S4-S5 linker regulates hERG channel closed-state stabilization.
Pflugers Arch
; 466(10): 1911-9, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24407947
6.
External protons destabilize the activated voltage sensor in hERG channels.
Eur Biophys J
; 43(2-3): 59-69, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24362825
7.
Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/- long QT syndrome variant.
Cardiovasc Res
; 119(15): 2522-2535, 2023 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37739930
8.
Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis.
Am J Physiol Cell Physiol
; 302(12): C1797-806, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22517356
9.
Mutations within the S4-S5 linker alter voltage sensor constraints in hERG K+ channels.
Biophys J
; 99(9): 2841-52, 2010 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21044581
10.
Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome.
Front Physiol
; 11: 624129, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33519527
11.
Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation.
J Gen Physiol
; 151(2): 231-246, 2019 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530765
12.
Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels.
J Gen Physiol
; 142(3): 289-303, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23980197
13.
Voltage-dependent gating of HERG potassium channels.
Front Pharmacol
; 3: 83, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22586397
14.
A difference in inward rectification and polyamine block and permeation between the Kir2.1 and Kir3.1/Kir3.4 K+ channels.
J Physiol
; 568(Pt 3): 749-66, 2005 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16109731