1.
Chem Res Toxicol
; 27(4): 480-2, 2014 Apr 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24628573
RESUMO
For DNA-reactive chemicals, a low dose linear assessment of cancer risk is the science policy default. In the present study, we quantitated the endogenous and exogenous N7-methyl-G and O(6)-methyl-dG adducts in human lymphoblastoid cells exposed to low dose [D3]-methylnitrosourea. Endogenous amounts of both adducts remained nearly constant, while the exogenous adducts showed linear dose-responses. The data show that O(6)-methyl-dG adducts ≥1.8/10(8) dG correlated with published studies that demonstrated significant increases of mutations under these conditions. The combined results do not support linear extrapolations to zero when data are available for science-based regulations.
Assuntos
Desoxiguanosina/análogos & derivados , Guanina/análogos & derivados , Metilnitrosoureia/farmacologia , Células Cultivadas , Desoxiguanosina/metabolismo , Relação Dose-Resposta a Droga , Guanina/metabolismo , Humanos , Metilnitrosoureia/administração & dosagem
2.
Am J Med
; 135(5): 592-594, 2022 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35026137