Detalhe da pesquisa
1.
Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations.
Biol Chem
; 400(2): 181-185, 2019 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29924730
2.
Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies.
Haematologica
; 104(5): 1016-1025, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30467206
3.
Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.
Mol Cell
; 35(3): 265-79, 2009 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19683492
4.
BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells.
Br J Cancer
; 114(6): 638-41, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26954718
5.
BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.
Blood
; 117(26): 7145-54, 2011 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21562047
6.
Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis.
Cell Death Dis
; 13(5): 436, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35508606
7.
The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.
Biochem Biophys Res Commun
; 408(2): 344-9, 2011 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21514278
8.
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia.
Blood
; 113(18): 4403-13, 2009 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-19008458
9.
Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.
Haematologica
; 95(9): 1510-8, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20378569
10.
Phenylarsine oxide interferes with the death inducing signaling complex and inhibits tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced apoptosis.
Exp Cell Res
; 315(14): 2453-62, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19465019
11.
Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis.
Proc Natl Acad Sci U S A
; 104(26): 10871-6, 2007 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17581882
12.
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase.
Mol Biol Cell
; 18(4): 1337-47, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17287400
13.
Caspase cleavage of Itch in chronic lymphocytic leukemia cells.
Biochem Biophys Res Commun
; 379(3): 659-64, 2009 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19073138
14.
DEDD regulates degradation of intermediate filaments during apoptosis.
J Cell Biol
; 158(6): 1051-66, 2002 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-12235123
15.
Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis.
Cell Death Dis
; 10(7): 521, 2019 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31285422
16.
DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.
Cell Death Discov
; 5: 117, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31341643
17.
BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL.
Cell Death Differ
; 26(6): 1037-1047, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30185825
18.
Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck.
Cell Death Dis
; 10(12): 912, 2019 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31801952
19.
ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.
Br J Haematol
; 163(1): 139-42, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23826785
20.
Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver.
Hepatology
; 46(5): 1498-508, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17705261