Detalhe da pesquisa
1.
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Nucleic Acids Res
; 47(3): 1070-1081, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30535404
2.
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Nucleic Acids Res
; 46(5): 2185-2196, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432571
3.
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
Mol Ther
; 26(11): 2580-2591, 2018 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30143435
4.
5Î-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
Nucleic Acids Res
; 45(13): 7581-7592, 2017 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28591791
5.
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.
Bioconjug Chem
; 28(6): 1758-1766, 2017 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28462988
6.
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.
Mol Ther
; 24(10): 1836-1847, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27506293
7.
Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.
Nucleic Acids Res
; 43(18): 8664-72, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26400165
8.
Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.
Proc Natl Acad Sci U S A
; 107(25): 11423-8, 2010 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20534538
9.
Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue.
Cancer Cell
; 4(5): 349-60, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-14667502
10.
Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains.
Brain Commun
; 4(6): fcac248, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36458209
11.
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.
Mol Ther Nucleic Acids
; 29: 116-132, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35795486
12.
Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.
Life Sci Alliance
; 5(3)2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34857647
13.
Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep.
JCI Insight
; 6(24)2021 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34935646
14.
The ING gene family in the regulation of cell growth and tumorigenesis.
J Cell Physiol
; 218(1): 45-57, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18780289
15.
Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.
Cancer Res
; 67(5): 2054-61, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17332334
16.
Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition.
iScience
; 16: 230-241, 2019 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31195240
17.
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
Nat Biotechnol
; 37(8): 884-894, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31375812
18.
siRNA goes after diseases of the bone.
Mol Ther Nucleic Acids
; 34: 102051, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37916226
19.
Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.
Mol Cancer Ther
; 17(6): 1251-1258, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29654062
20.
Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.
Cell Rep
; 24(10): 2553-2560.e5, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30184490