1.
Bioorg Med Chem Lett
; 18(20): 5451-5, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18818070
RESUMO
Starting from a weak omeprazole screening hit, replacement of the pyridine with a 1,3-benzodioxole moiety, modification of the thioether linkage, and substitution of the benzimidazole pharmacophore led to the discovery of nanomolar BRS-3 agonists.