Detalhe da pesquisa
1.
Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Bioorg Med Chem
; 25(20): 5433-5440, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28807574
2.
Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.
Diabetologia
; 57(1): 129-39, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24149836
3.
Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.
Proc Natl Acad Sci U S A
; 108(14): 5620-5, 2011 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21436030
4.
Palladium- and nickel-catalyzed alkenylation of enolates.
Chemistry
; 19(6): 1858-71, 2013 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23325616
5.
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
Bioorg Med Chem
; 16(23): 10061-74, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18952446
6.
Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.
ACS Infect Dis
; 3(7): 512-526, 2017 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28350440
7.
Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound.
Synthesis (Stuttg)
; 48(13): 2065-2068, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27482123
8.
Concise, convergent syntheses of (±)-trichostatin A utilizing a Pd-catalyzed ketone enolate α-alkenylation reaction.
Org Lett
; 13(14): 3564-7, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21688856
9.
Selective oxidation of benzylic and allylic alcohols using Mn(OAc)3/catalytic 2,3-dichloro-5,6-dicyano-1,4-benzoquinone.
Org Lett
; 13(8): 2071-3, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21395252
10.
Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.
J Med Chem
; 53(14): 5281-9, 2010 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20557099
11.
Investigation of N-aryl-3-alkylidenepyrrolinones as potential Niemann-Pick type C disease therapeutics.
J Med Chem
; 52(20): 6494-8, 2009 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19772346