Detalhe da pesquisa
1.
Messenger RNA rescues medium-chain acyl-CoA dehydrogenase deficiency in fibroblasts from patients and a murine model.
Hum Mol Genet
; 32(14): 2347-2356, 2023 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37162351
2.
Synthetic mRNA rescues very long-chain acyl-CoA dehydrogenase deficiency in patient fibroblasts and a murine model.
Mol Genet Metab
; 138(1): 106982, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36580829
3.
mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency.
Mol Ther
; 27(7): 1242-1251, 2019 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31056400
4.
PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.
J Biol Chem
; 291(11): 5664-5675, 2016 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26797128
5.
The effects of troglitazone on AMPK in HepG2 cells.
Arch Biochem Biophys
; 623-624: 49-57, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28526426
6.
Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/49¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle.
Arch Biochem Biophys
; 562: 62-9, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25172224
7.
Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.
Circ Res
; 111(8): 1012-26, 2012 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22904094
8.
Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria.
Nat Commun
; 15(1): 3804, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38714648
9.
Lipid nanoparticle-encapsulated mRNA therapy corrects serum total bilirubin level in Crigler-Najjar syndrome mouse model.
Mol Ther Methods Clin Dev
; 29: 32-39, 2023 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36936447
10.
Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues.
Am J Physiol Endocrinol Metab
; 301(2): E380-90, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21586699
11.
Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats.
PLoS One
; 10(5): e0127388, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25996822
12.
AMPK activation: a therapeutic target for type 2 diabetes?
Diabetes Metab Syndr Obes
; 7: 241-53, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25018645
13.
Nutrient Excess in AMPK Downregulation and Insulin Resistance.
J Endocrinol Diabetes Obes
; 1(1): 1008, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-26120590