1.
Cancer Genet Cytogenet
; 121(2): 206-7, 2000 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11063809
RESUMO
A patient with refractory anemia and a paracentric inversion of chromosome 12, inv(12)(q15q24), is described. This is the second reported case with this chromosome anomaly, suggesting that this rearrangement is a rare but nonrandom change associated with myelodysplastic syndromes.
Assuntos
Inversão Cromossômica , Cromossomos Humanos Par 12 , Síndromes Mielodisplásicas/genética , Idoso , Feminino , Humanos , Cariotipagem
2.
Br J Haematol
; 110(1): 214-6, 2000 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10931001
RESUMO
Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration.