Detalhe da pesquisa
1.
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Bioorg Med Chem Lett
; 24(3): 917-22, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24412110
2.
Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma.
Am J Respir Cell Mol Biol
; 45(1): 81-7, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855652
3.
Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin.
Biol Chem
; 391(12): 1469-73, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20868234
4.
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.
Bioorg Med Chem Lett
; 20(3): 887-92, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20061146
5.
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
Bioorg Med Chem Lett
; 18(3): 923-8, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18226527
6.
PTP1B-dependent insulin receptor phosphorylation/residency in the endocytic recycling compartment of CHO-IR cells.
Biochem Pharmacol
; 72(10): 1279-92, 2006 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16956584
7.
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.
J Med Chem
; 48(24): 7535-43, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16302795
8.
Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors.
J Renin Angiotensin Aldosterone Syst
; 12(3): 133-45, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21393355
9.
Basal activation of p70S6K results in adipose-specific insulin resistance in protein-tyrosine phosphatase 1B -/- mice.
J Biol Chem
; 282(42): 30423-33, 2007 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17664276
10.
The identification of potent, selective, and bioavailable cathepsin S inhibitors.
Bioorg Med Chem Lett
; 17(17): 4929-33, 2007 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17590332
11.
An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells.
Anal Biochem
; 335(2): 218-27, 2004 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15556560
12.
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
Bioorg Med Chem Lett
; 13(6): 1195-8, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12643942
13.
The development of potent non-peptidic PTP-1B inhibitors.
Bioorg Med Chem Lett
; 14(4): 1039-42, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15013019
14.
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
Bioorg Med Chem Lett
; 14(4): 1043-8, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15013020
15.
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
Biochemistry
; 42(39): 11451-9, 2003 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-14516196